Mast cell degranulation

Question 1

Histamine

Answer 1

Vasoactive amine that causes temporary, rapid constriction of the large blood vessels and the dilation of the postcapillary venules.

Question 2

H1 receptors:

Answer 2

Pro-inflammatory seen in smooth muscle cells of the bronchi - they induce bronchoconstriction.

Question 3

H2 receptors

Answer 3

Anti-inflammatory on the parietal cells of the stomach mucosa - they induce the secretion of gastric acid. Antihistamines work on these receptors.

Question 4

Leukotrienes

Answer 4

• Product of the arachidonic acid from mast cell membranes.
• Similar effects to histamine in later stages

Question 5

Prostaglandins

Answer 5

• Similar effects to leukotrienes.
• Induces pain.

Question 6

Platelet-activating factor:

Answer 6

• Similar effect to leukotrienes.
• Responsible for platelet activation.