Maxillofacial Infections Flashcards
(48 cards)
General principles for Antibiotics.
NETCC
Necessary Efficacy Toxicity Compliance Cost
Easiest way to tell if there’s an infection.
Take temperature
Abs that can make the patient deaf.
Aminogylcoside abs
These can getrid of cellulitis, but NOT an abscess.
Antibiotics
Only way to get rid of an abscess.
Drain it.
Difference between cellulitis and an abscess.
Cellulitis is generalized inflammation WITHOUT pus.
An abscess has pus.
Local signs of an infection
Pain, edema, erythema, heat, loss of function
A typical odontogenic infection is pure or mixed?
Mixed infection containing 10-15 different bacterial species.
These types of bacteria make penicillinases to break down penicillin.
Gram negatives
Animal studies are positive and no human studies have been done.
FDA Class C drug
Most antibiotics are what FDA class?
C
Metabolizes 50% of all clinical drugs.
CYP3A
Inhibits CYP3A
grapefruit juice
A generalized inflammatory response.
Cellulitis
Localized accumulation of purulent exudate in an anatomic space.
Abscess
Most common reason why an antibiotic is not working.
Compliance
3 factors FDA looks at to determine if a generic drug can be used in place of a brand-name drug.
1) Bioequivalence
2) Reliability
3) Therapeutic equivalence
When do drugs expire by the expiration date listed on the bottle?
Once they’re opened
The expiration date on the bottle means almost nothing, with the exception of ____.
Epinephrine
These drugs cause the kidney tubules to necrose if taken after the expiration date.
Tetracyclines
This drug loses 90 % of its potency 10 months after the expiration date.
Epinephrine.
Esp. important in an EpiPen
Antibiotics and pregnancy.
Can increase chances of getting pregnant bc it prevents the oral contraceptives from working properly.
This antibiotic DEFINITELY DECREASES the effect of oral contraceptives to increase chances of getting pregnant.
Rifampin
Ab used for Tuberculosis.
Rifampin
