Mcb 2

Question 1

What is the primary demographic affected by Adenovirus infections?

Answer 1

Children

Adult infections can also occur.

Question 2

Can different serotypes of Adenovirus produce the same clinical syndrome?

Answer 2

Yes

Question 3

What is the incubation period for Adenovirus infection?

Answer 3

5-8 days

Question 4

What types of immunity occur in Adenovirus infection?

Answer 4

Both cell mediated immunity (CMI) & humoral immunity

Question 5

What is the role of CMI in Adenovirus infection?

Answer 5

Limiting viral proliferation & outgrowth

Question 6

What happens in the pathogenesis of oncogenic transmission by Adenovirus?

Answer 6

Virus multiplication is inhibited, allowing viral DNA integration into host cell DNA

Question 7

What proteins are produced by integrated Adenovirus DNA?

Answer 7

E1A proteins

Question 8

Has oncogenesis been demonstrated in humans with Adenovirus?

Answer 8

No

Question 9

Where can Adenovirus become latent?

Answer 9

Lymphoid tissue, adenoids, tonsils, Payer’s patches

Question 10

What can reactivate latent Adenovirus infections?

Answer 10

Co-infection with other agents, immunocompromised state

Question 11

What type of infection results from Adenovirus infecting muco-epithelial cells?

Answer 11

Lytic infection

Question 12

How is Adenovirus transmitted?

Answer 12

Faecal–oral route, aerosol droplet, direct inoculation of conjunctivas, indirect through fomites

Question 13

What is the size of Adeno-associated viruses (AAV)?

Answer 13

20-25 nm

Question 14

What is the family and genus of Adeno-associated viruses?

Answer 14

Family: Parvoviridae, Genus: Dependoviridae

Question 15

What is the mode of transmission for Adenovirus?

Answer 15

Respiratory, faecal-oral

Question 16

Are there vaccines available for Adenovirus?

Answer 16

Yes, in military only

Question 17

What clinical syndrome is caused by serotypes 4 & 7?

Answer 17

Acute respiratory disease

Question 18

What are the symptoms of pharyngoconjunctival fever?

Answer 18

Fever, sore throat, coryza, red eye

Question 19

What serotypes predominantly cause epidemic keratoconjunctivitis?

Answer 19

Serotype 8, less often 19 & 37

Question 20

What is the association of serotypes 40 & 41?

Answer 20

Most associated with gastroenteritis & diarrhea

Question 21

What laboratory specimens are used for Adenovirus diagnosis?

Answer 21

Throat, eye, urine, faeces, CSF specimens

Question 22

What cell cultures can isolate Adenovirus?

Answer 22

Human embryonic kidney, HeLa, Hep2 cells

Question 23

How many serotypes are associated with human diseases in the Adenoviridae family?

Answer 23

47

Question 24

What are the unique properties of Adenoviruses?

Answer 24

Mostly infect children, infections often asymptomatic, produce disease of eye, respiratory tract, urinary tract, GIT

Question 25

What is the Baltimore classification of viruses based on?

Answer 25

Nucleic acid types and m-RNA production mechanism

Question 26

What types of viruses are classified under ds-DNA viruses?

Answer 26

Adenoviridae, Poxviridae, Herpesviridae, Hepadnaviridae, Papovaviridae

Question 27

What is the shape and size of Adenoviruses?

Answer 27

Icosahedral, medium-sized (80-110 nm diameter), nonenveloped

Question 28

What type of virus is Adenovirus classified as?

Answer 28

Double-stranded DNA virus

Question 29

What is the characteristic feature of Adenovirus structure?

Answer 29

Each vertex bears 1 fibre projection