MDN Flashcards
1
Q
Genetic mutation commonly associated with ALS
A
SOD1
2
Q
MND typical presentations at onset
A
one limb involved usually
Can be bulbar signs
Less common is fasciculations, spacicity
3
Q
MND examination: in hands what does split hand syndrome refer to?
A
wasting of first dorsal interossei plus adductor policis brevis
4
Q
What gene is associated with both MND and frontotemporal dementia?
A
C9ORF72 gene
5
Q
What is the MOA of Riluzole
A
reduces glutamate mediated excitotoxicity
6
Q
Effect of MDT care on survival
A
delays mortality by 1 year
7
Q
Effect of NIV care on survival
A
improved survival, improved QOL
