Mechanism of Action

Question 1

Amphotericin B

Answer 1

binds to ergosterol (a fungal cell membrane component) increasing cell permeability = cell death

BROAD spectrum: histoplasma, blastomyces, coccidioides, aspergillus, candida species, crypto neoformans

Question 2

Diflucan

Answer 2

decreased ergosterol synthesis to block cell membrane formation

Question 3

Nizoral A-D

Answer 3

Ketoconazole
decreased ergosterol synthesis to block cell membrane formation

Question 4

Vfend

Answer 4

Voriconazole
decreased ergosterol synthesis to block cell membrane formation

Question 5

Noxadil

Answer 5

Posaconazole
decreased ergosterol synthesis to block cell membrane formation

Question 6

Cancidas

Answer 6

Caspofungin
inhibits sythesis of beta (1,3)-D-glucan of the fungal cell WALL

Question 7

Mycamine

Answer 7

Micafungin
inhibits sythesis of beta (1,3)-D-glucan of the fungal cell WALL

Question 8

Tamiflu

Answer 8

Oseltamivir
Neuraminidase inhibitor that reduces the amount of virus in the body by inhibit the enzyme that releases NEW viral particles

**MUST use within 48 hours

Question 9

Baloxavir
(Xofluza)

Answer 9

used for treatment and post exposure prevention of influenza
endonuclease inhibitor

Question 10

Zovirax

Answer 10

Acyclovir
blocks DNA synethesis and viral replication by incorporating into viral DNA

Question 11

Valtrex

Answer 11

Valacyclovir
prodrug of acyclovir - blocks DNA synethesis and viral replication by incorporating into viral DNA

Question 12

Ganciclovir

Answer 12

blocks DNA synethesis and viral replication by incorporating into viral DNA

Treatment of Cytomegalovirus

Question 13

Valcyte

Answer 13

Valganciclovir
blocks DNA synethesis and viral replication by incorporating into viral DNA

Treatment of Cytomegalovirus

Question 14

Mavyret

Answer 14

Glecaprevir - NS3/4A protease inhibitors
Pibrentasvir - NS5A Replication Complex inhibitor

Question 15

Epclusa

Answer 15

Sofosbuvir - NS5B Polymerase inhibitor

Velpatasvir - NS5A Replication Complex inhibitor

Question 16

Dasabuvir

Answer 16

NS5B Polymerase inhibitor

Question 17

Grazoprevir

Answer 17

NS3/4A - Protease inhibitor

Question 18

Elbasvir

Answer 18

NS5A Replication Complex inhibitor

Question 19

Ledipasvir

Answer 19

NS5A Replication Complex inhibitor

Question 20

Ombitasvir

Answer 20

NS5A Replication Complex inhibitor

Question 21

Paritaprevir

Answer 21

NS3/4A protease inhibitor

Question 22

Voxilaprevir

Answer 22

NS3/4A protease inhibitor

Question 23

Viread

Answer 23

TDF
NRTI - inhibits HBV replication

MONOTHERAPY for HBV

Question 24

Vemlidy

Answer 24

TAF
NRTI - inhibits HBV replication

Monotherapy for HBV

Question 25

Baraclude

Answer 25

Entecavir NRTI - inhibits HBV replication *preferred therapy for HBV

Question 26

Interferon Alfa

Answer 26

cytokine that have antiviral, antiproliferative, and immunomodulatory effects pegylated formulation has increased half life treatment for HBV or HCV

Question 27

Ribavirin

Answer 27

inhibits the replication of RNA and DNA of viruses - used ONLY for HCV but NOT monotherapy