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Pharmacology Chapter 31 > Mechanisms/Drug Class > Flashcards

Mechanisms/Drug Class Flashcards

(38 cards)

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1
Q

What is the mechanism of action of hormone replacement therapy?

A

Decrease bone resorption by osteoclasts

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2
Q

estrogen + progestin

A

hormone replacement therapy

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3
Q

What is the mechanism of action of selective receptor modulators (SERMs)?

A

Estrogen receptor agonist in bone, estrogen antagonist in endometrium and breast

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4
Q

raloxifene

A

SERM

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5
Q

What is the mechanism of action of bisphosphonates?

A

Decrease bone resorption by osteoclasts

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6
Q

alendronate

A

bisphosphonate

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7
Q

risedronate

A

bisphosphonate

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8
Q

ibandronate

A

bisphosphonate

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9
Q

pamidronate

A

bisphosphonate

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10
Q

zoledronate

A

bisphosphonate

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11
Q

What is the mechanism of action of RANKL antagonists?

A

Decrease bone resorption by osteoclasts

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12
Q

denosumab

A

RANKL antagonist

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13
Q

What is the mechanism of action of calcitonin?

A

Decrease bone resorption by osteoclasts

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14
Q

salmon calcitonin

A

calcitonin

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15
Q

What is the mechanism of action of bone anabolic agents?

A

Increase bone formation by osteoblasts

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16
Q

hPTH 1-34 (teriparatide)

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A

bone anabolic agent

17
Q

hPTH 1-84

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A

bone anabolic agent

18
Q

fluoride

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A

bone anabolic agent

19
Q

What is the mechanism of action of oral phosphate binders?

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A

Decrease GI absorption of dietary inorganic phosphate

20
Q

aluminum hydroxide

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A

oral phosphate binder

21
Q

calcium carbonate

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A

oral phosphate binder

22
Q

calcium acetate

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A

oral phosphate binder

23
Q

sevelamer

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A

oral phosphate binder

24
Q

What is the mechanism of action of vitamin D and analogues?

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A

Increase GI absorption of dietary calcium, decrease transcription of PTH gene

25
cholecalciferol (vit D3)
vitamin D
26
ergocalciferol (vit D2)
vitamin D
27
calcifediol (25(OH)D3)
vitamin D analogue
28
calcitriol (1,23(OH)2D3)
vitamin D analogue
29
doxercalciferol (1alpha-(OH)D2)
vitamin D analogue
30
paricalcitol (19-nor-1,25(OH2)D2)
vitamin D analogue
31
What is the mechanism of action of calcimmetics?
Increases sensitivity of calcium-sensing receptor to calcium in parathyroid cells, causes decreased secretion of PTH
32
cinacalcet
calcimmetic
33
What is the mechanism of action of calcium?
Essential for bone mineralization
34
calcium gluconate
calcium (IV)
35
calcium carbonate
calcium (oral)
36
calcium citrate-malate
calcium (oral)
37
What is the mechanism of action of inorganic phosphate?
Essential for bone mineralization
38
potassium phosphate (pH 7)
inorganic phosphate

Pharmacology Chapter 31 (5 decks)

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