Medication For STRESS URINARY INCONTINENCE Flashcards
Used to treat women with stress and urgency urinary incontinence
ESTROGEN REPLACEMENT THERAPY
Tricyclic antidepressant in women who have a coexisting stress and urgency urinary incontinence
• may relax the bladder through its anticholinergic effect and constrict the urethra through its alpha-agonistic effect
IMIPRAMINE
an FDA-approved serotonin and norepinephrine reuptake inhibitor drug to treat depression, chronic pain, and anxiety, but not for stress urinary incontinence.
DULOXETINE
mechanism of action on the bladder is to increase bladder storage and improve urethral sphincter function via its effect on the central nervous system
DULOXETINE
administered at a low dose, with subsequent increase in dosage after a period of 4 to 6 weeks should there be no significant improvement
Anticholinergics
an immediate-release was the first FDA-approved anticholinergic drug, but it has a short half-life and is taken three times a day.
• Extended-release medications tend to be better tolerated because of their once daily administration, and a lower side-effect profile
Oxybutynin
a quaternary amine anticholinergic, which is hydrophilic with a large molecular size limiting its distribution into the central nervous system and reducing its effect on cognition
Trospium chloride
First line treatment for urgency urinary incontinence, followed by medical interventions
Behavioral therapies
Second class of medications to treat urgency urinary incontinence
Beta agonists
Beta 3 receptor agonist
Mirabegron
medication used to treat nocturia or enuresis = effective mostly through its central inhibitory action on reducing urine production
Desmopressin
work centrally to improve sleep, and peripherally on the bladder and urethra to improve bladder storage
Anticholinergics can be used to help with nocturia, especially in women with OAB
Imipramine
can be helpful, especially in the presence of vascular insufficiency and peripheral edema
Furosemide
