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General study MD3 > Medication GP > Flashcards

Medication GP Flashcards

1
Q

Linagliptin

A

DPP4 inhibitor

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2
Q

Alogliptin

A

DPP4 inhibitor

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3
Q

Sitagliptin

A

DPP4 inhibitor

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4
Q

Duloxetine

A

SNRI - inhibit serotonin and noradrenaline reuptake

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5
Q

Fluoxetine

A

SSRI - inhibit the presynaptic reuptake of serotonin (5-hydroxytryptamine, 5HT)

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6
Q

Meloxicam (mobic, moxicam, melobic)

A

Selective COX-2 inhibitor NSAID

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7
Q

MOA NSAIDS

A

Analgesic, antipyretic and anti-inflammatory actions. Inhibit synthesis of prostaglandins by inhibiting cyclo-oxygenase (COX) present as COX1 and COX2
- Inhibition of COX1 results in impaired gastric cytoprotection and antiplatelet effect
- inhibition of COX2 results in anti-inflammatory and analgesic action
- Reduction in GFR and renal blood flow occurs with both COX1 and COX2 inhibition

Most NSAIDs are nonselective, inhibiting both COX1 and COX2.

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8
Q

Celecoxib

A

Selective COX2 inhibitor NSAID

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9
Q

Naproxen

A

Nonselective NSAID

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10
Q

Indometacin

A

nonselective NSAID

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11
Q

Diclofenac

A

Nonselective NSAID

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12
Q

Xanthine oxidase inhibitors MOA

A

Inhibit xanthine oxidase which reduces production of uric acid, lowering serum urate concentration and allowing acute flares and crystal deposits to resolve if long-term serum urate <0.36mmol/L

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13
Q

Allopurinol: class + indications

A

Xanthine oxidase inhibitor
Indications: symtomatic hyperuricemia (gout)

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14
Q

Febuxostat (class + indications)

A

Xanthine oxidase inhibitor
Indications: symtomatic hyperuricemia (gout) - second line behind allopurinol

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15
Q

Cefalexin (cephalex, ibilex, keflex, cephalexin) - class and indications

A

Cephalosporin
Staphylococcal and streptococcal infections in people with mild to moderate penicillin allergy, UTI, epididymo-orchitis (urinary tract source)

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16
Q

Cefazolin

A

Cephalosporin (Abx)

17
Q

Cefaclor

A

Cephalosporin (Abx)

18
Q

Cephalosporin MOA

A

Interfere with bacterial cell wall peptidoglycan synthesis by binding to penicillin-binding proteins, eventually leading to cell lysis and death; bactericidal.

19
Q

Carbapenems MOA

A

Inhibit bacterial cell wall synthesis by binding to penicillin-binding proteins, the affinities for which differ between the carbapenems and may affect their activity in vitro; usually bactericidal.

20
Q

Macrolides MOA

A

Bacteriostatic; inhibit bacterial protein synthesis by binding to the 50S ribosomal subunit. They also have immunomodulatory and anti-inflammatory effects.

21
Q

Macrolides - spectrum

A

Broad-spectrum antibacterials active against Gram-positive and some Gram-negative bacteria; also active against M. pneumoniae, Treponema pallidum, Bordetella pertussis, and Chlamydia, Chlamydophila, Legionella, Campylobacter and Borrelia spp. Macrolides are not active against enterococci.

22
Q

Azithromycin

A

Macrolide

23
Q

Clarithromycin

A

Macrolide

24
Q

Erythromycin

A

Macrolide

25
Q

Penicillin MOA

A

Bactericidal; interfere with bacterial cell wall peptidoglycan synthesis by binding to penicillin-binding proteins, eventually leading to cell lysis and death.

26
Q

Amoxicillin - class and indications

A

Penicillin

Indications - exacerbation of chronic bronchitis, CAP, acute otitis media, sinusitis, gonococcal infection, epididymo-orchitis, acute prostatitis, acute pyelonephritis, UTI, endocarditis prophylaxis in high risk patients, acute cholecystitis, peritonitis, eradication of H pylori

27
Q

Amoxicillin with clavulanic acid (amoxiclav) MOA

A

Clavulanic acid inhibits beta-lactamase, which extends spectrum of activity of amoxicillin with clavulanic acid to cover some beta-lactamase-producing organisms.

28
Q

Amoxiclav indications

A

HAO, epididymo-orchitis (urinary tract source), PID (not sexually acquired), UTI, bites and clenched fist injuries, acute otitis media, sinusitis (unresponsive to amoxicillin), acute cholecystitis, melioidosis

29
Q

Ampicillin - class

A

Penicillin

30
Q

What is lexapro?

A

Escilatopram - SSRI

31
Q

What is targin?

A

Oxycodone with naloxone - opioid analgesic

32
Q

Oxycodone class + indications

A

Opioid analgesic
Severe pain

33
Q
A

General study MD3 (8 decks)

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