Medications Affected by Kidney Function

Question 1

Nitrofurantoin

Answer 1

Avoid if eGFR <30
- caution if 30-40

Question 2

Vancomycin

Answer 2

Prolong dose intervals in severe impairment

Question 4

Gentamicin

Answer 4

1. Reduce dose
2. Increase dose intervals
   - this avoids build up of toxic concentrations

Question 5

Heparins

Answer 5

Reduce dose in renal impairment

Question 6

Dabigatran

Answer 6

Avoid if eGFR <30
Reduce dose if eGFR 30-50

Question 7

Apixaban, Edoxaban and rivaroxaban

Answer 7

Avoid if eGFR < 15

Question 8

Metformin

Answer 8

Avoid if eGFR <30

Question 9

Digoxin

Answer 9

Reduce initial and maintenance dosing