Medicinal Chemistry: Anaesthesia and Analgesia lecture Flashcards Preview

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Flashcards in Medicinal Chemistry: Anaesthesia and Analgesia lecture Deck (14)
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1

How is Cocaine isolated

Cocaine is isolated from natural sources

2

Procaine

Local anaesthetic

3

Which Local Anaesthetics has longer duration of action

Lidocaine (Amino amide)

4

Henderson-Hasselbalch Equation

what % of drug is ionised in a particular point of the body

5

pH of skin

5.5

6

pH of blood plasma

7.4

7

local anaesthetics are

weak bases

8

How do local anaesthetics work

- local anaesthetics work by blocking sodium channels
- for a local anaesthetic to work some must be de-protonated

9

Tetracaine has

2 ionisable centres

10

Local Anaesthetics: SAR

Need to have an aromatic group, lipophilic group and at least one ionisable group

11

Zwitterionic

ion which has a positive and negative charge

12

Codeine activity

codeine has no activity as an opioid

13

Opioid Analgesics

weak bases

14

4-Phenylpiperidines

- used widely as analgesia in child birth for anaesthetic of lower back
- lower activity than morphine and shorter duration of action