Medicine/Patho/Physio Flashcards
(99 cards)
1
Q
Sickle cell anemia Xray findings
A
Hair on end/crew cut on skull
H shaped vertebrae
2
Q
AutoAb in PSC
A
pANCA
3
Q
AutoAb in PBC
A
AMA
4
Q
West syndrome Mx
A
ACTH
5
Q
DOC for West syndrome + TuberousSclerosis
A
Vigabatrin
6
Q
Name of scoring for TIA
A
ABCD2
7
Q
Garden party appearance
A
CML
8
Q
Aur rods
A
AML
9
Q
Mutation of which gene and loss of which compliment regulator occur in PNH
A
Pig A gene mutation
CD 55/59 loss
10
Q
Rx of PNH
A
Eculizumab ( C5 inhibitor)
11
Q
Heinz body seen in
A
G-6-PD Def.
12
Q
DOC for TTP
A
Inj. ADAMTS-13
13
Q
å _ /_ _ of thalassemia known as
A
HbH
14
Q
_ _ / _ _ of thalassemia known as
A
BART
15
Q
Mutation in Wilson D/s
A
ATP 7B - Chr 13
16
Q
Mutation in Menkes D/s
A
ATP 7A
17
Q
Gardner Sx finding
( 4 c/f )
A
Supernumery teeth
Osteoma
Fibroma
CHRPE
(Asso. With FAP)
18
Q
Neurofibrillary tangles seen in
A
Alzheimer’s d/s
19
Q
Amyloid associated with Alzheimer’s
A
Aβ40 and Aβ42
20
Q
Dawson fingers seen in
A
Multiple sclerosis
21
Q
Albumino Cytological dissociation seen in
A
GBS
Normal WBC count
Elevated protein
22
Q
GABA produced from
A
Nucleus Accumbens
23
Q
What is the main source of Noradrenaline in the brain?
A
Locus Coeruleus
24
Q
What is Hakim’s triad?
A
Walking difficulty (wobble)
Reduced attention span (wacky)
Urinary frequency or incontinence (wet)
(Wet - wacky - wobble )
Seen in NPH
25
Factors causing contraction in Peristalsis
Substance P
Ach
26
Factors causing relaxation in Peristalsis
NO
VIP
27
Which cell produce Somatostatin
D cell (pancreatic islets)
28
Which cell produce CCK
I cell (andrum, duodenum,jejunum)
29
Pancreatic HCO3 secretion increased by which substance
Secretin
30
GLP produced from
K cells (duodenum, jejunum)
31
Action of Ghrelin
Increase Appetite
32
Absorption of B12 occur in
Ileum
33
Why Omeprazole and Clopidogrel can't use simultaneously
Both act on **CYP2C19**
34
Triple drug therapy for H.Pylori
CAP
C- Clarithromycin
A- Amox
P- PPI
35
Most Alkaline pH in GIT is at
Brunners Gland (Duodenum)
36
Max **amount** of K secretion in GIT
Saliva
37
MOA of Lopiramide
µ Agonist
38
MOA of Racecodotril
Enkephalinase inhibitor
( decrease opioid metabolism)
39
Melanosis coli seen in
Senna ( A/e of Senna use)
Senna used in constipation
40
MOA of Prucalopride
5HT - 4 agonist
(Use - constipation)
4four for " Thoor"
41
MOA of Ondansetron
5HT3 Blocker
(Ondan /Granny)
42
Doc for sea sickness
Meclizine
43
Doc for motion sickness
Hyoscine
44
Doc for Morning sickness
Doxyllamine + Vit B6
45
DOC in Levodopa induced Vomiting
Domperidone
(Dopa for Domperidone)
46
MOA of Metoclopromide
D2 Blocker
47
MOA of Domperidone
D2 Blocker
48
Doc in Delayed vomiting in Post-chemo
Aprepitant
(Chemok appramaa use panrath)
49
MOA of Aprepitant
NK1/Substance P inhibitor
50
SAAG more than 1.1g/dL
Ascitic protein more than 2.5g/dL
Indicate!?
1.Budd chiarri synd
2.Constrictive pericarditis
3.RCM
51
SAAG more than 1.1g/dL
Ascitic protein less than 2.5g/dL
Indicate!?
Cirrhosis
52
SAAG less than 1.1g/dL
Indicate
1.Nephrotic
2.TB
3.Malignancy
4.Pancreatitis
53
Travellers Diarrhoea is caused by
ETEC
54
Treatment of Moderate Ascites
Furosemide (1st line)
.
If fails
.
Spironolactone/Eplerenone
55
Bloody diarrhoea
H/o poultry and egg ingestion
Salmonella
56
Diarrhoea after 6hrs
H/o eating Shellfish
V. Paraheamolyticus
57
Which HLA is positive in Celiac disease
HLA- DQ 2
58
Which antibody positive in Ulcerative Colitis
pANCA
59
Which antibody positive in Crohns
ASCA
60
Mutation asso. With Juvenile polyp
SMAD - 4
61
Mutation asso with Peutz Jeghar synd.
STK 11
62
Mutation asso. With Cowden synd.
PTEN
63
Features of Turcot synd.
Medulloblastoma
Glioblastoma Multiforme
(Turcot - turban - head)
64
Mutations in Adenoma -Carcinoma sequence of GIT
APC at **5**q21
APC - Beta Catenin
K-RAS at **12**p21
TP53 at **17**p13
65
Features of Hemochromatosis
HFE mutation
Prussian blue pearls on H/P
Black liver on MRI
Skin - bronze
RCM
Hook shaped metaCarpals
66
Doc of SBP
Cefotaxime
67
Hypoxia **only** during sleeping
PaO2 Normal during day
Snoring
Day time sleepiness
Obstructive sleep apnea
68
Hypoxia only during sleeping
PaO2 Normal during day
Thoraco abd. Msl not moving
Central sleep apnea
69
PaCO2 high during Day and night
Obesity
Hypoventilation
Pickwickian syndrome
70
Exudative Pleural effusion examples
Pneumonia
Viral infection
Malignancy
TB
PE
71
Transudative Pleural effusion examples
Nephrotic syndrome
Hypoalbuminemia
CHF
Cirrhosis
PE
72
Types of Respiratory Failure
Type 1 - Hypoxemic (PE,P.Edema, Pneumonia,ILD)
Type 2 - Hypercapnic (C-O-P-D)
Type 3 - postOp (Atelectasis)
Type 4 - Shock with Hypoperfusion
73
Batwing sign on CXR seen in
Cardiogenic Pulmonary Edema
74
goal and limit of TV,RR,platue pressure and fiO2 in **ARDS**
TV < **6**ml/kg
FiO2 < **0.6**
RR < **35**
Platue pressure < **30** cm of H2O
75
Virchows Triad
1. Stasis
2. Hypercoagulation
3. Endothelial injury
76
PE scoring
Modified Wells scoring
77
In PE Wells score is 5 what will do next
CTPA
If score more than 4 do CTPA (ioc)
If less than 4 do **D-Dimer**
to r/o PE
78
CXR and H/P finding in Pulm Art. HTN
Jughandle sign on CXR
Plexiform arteriopathy on Histology
79
CURB-65
**C**onfusion
**U**rea - BUN>19mg or >7mmol
**R**R > 30
**B**P < 90/60
80
Kartagener syndrome triad
1.Situs inversus
2.chr. sinusitis
3.Brochiectasis
81
IHC of SCC of lung
P40
P63
82
IHC of small cell Ca of lung
Synaptophysis
NSE
Chromogranine
83
IHC of AdenoCa lung
TTF - 1
Napsin A
84
NTs levels in Huntington disease
Dopamine increases
Ach and GABA decreases
85
NTs change in Alzheimer's
Ach decreases
86
Pulvinar sign/Hockey stick 🏒 sign seen in
CJD or Prions disease
87
DOC for mild Alzheimer's
Donepezil ( Ach**E** inhibitor)
88
Brain imaging finding in ADEM
ADEM (Acute disseminated Encephalomyelitis)
- Multiple cloud like lesions on brain
89
Ab in Devic's disease
Anti Aq2
90
Charcot triade in MS
**S**canning speech
**I**ntension tremor
**N**ystagmus
91
T/t of GBS
IV**IG** + Plasmapheresis
( Steroids **C/I** )
92
Holy cross bun sign on pons
Multisystem Atrophy - C
93
Humming bird sign on midbrain image
Progressive supranuclear palsy
94
Gestman syndrome
Etiology!?
Features!?
Area 39 (angular gyrus) injury
Pt with Agraphia/ Acalculia/ Finger agnosia/ Rt Lt spacial disorientation
95
What artery causes thalamic pain syndrome?
Geniculostriate Artery
96
Benzene Exposure will cause
AML
97
Cadmium exposure will cause
Prostate cancer
98
Rx of Non Hodgkin lymphoma
RCHOP
Rituximab
Cycloph.
HydroxyDanorubicine
Oncovin
Prednisolone
99
Rx of Non Hodgkin lymphoma
RCHOP
Rituximab
Cycloph.
HydroxyDanorubicine
Oncovin
Prednisolone
