Pharma/Biochem Flashcards
(102 cards)
1
Q
Macrolide action on MMC in GIT
A
Motilin agonist
2
Q
Furosemide+ NSAID
A
Do not combine
Vasodilatory effect of furosemide is inhibited by NSAID.
3
Q
DOC in Li induced DI
A
Amloride
4
Q
ENaC activity increase in which disease
A
Liddle’s
5
Q
NaK2Cl activity affected in!?
A
Barter’s
6
Q
NaCl activity DT affected in!?
A
Gittleman
7
Q
Missense mutation
A
Sickle cell anemia
8
Q
Frame shift mutation
A
Duchene MD
Tay sach
9
Q
Splice site mutation
A
Gouchers
Marfan
10
Q
Base Excision Repair (BER)
A
MYUTH
11
Q
Mismatch repair
A
HNPCC
12
Q
Nucleotide Excision Repair (NER) defect
A
Xeroderma pigmentosum
Trichothiodystrophy
Cockayne syndrome
13
Q
Non Homogeneous End Joining (NHEJ) repair defect
A
SCID
14
Q
3’ to 5’ direction is in
A) DNA Repair
B) RNA editing
A
RNA editing
15
Q
DOC for Digoxin induced VT
A
Lignocaine
16
Q
DOC for Digoxin induced SVT
A
Beta blockers
17
Q
Statin act on which enzyme
A
HMG CoA reductase
18
Q
Which drug decrease Lipoprotein a
A
Niacin
19
Q
Late Na channel blocker
A
Ranolazine
20
Q
MOA of Ivabradine
A
Inhibitor of funny current of SA node
21
Q
MOA of Nicorandil
A
K+ ATP channel agonist
22
Q
MOA of Fusadil
A
Rho-kinase inhibitor
23
Q
MOA of Evolokumab
A
PCSK9 Inh
24
Q
DOC for Cirrhotic edema
A
Spironolactone
25
A/E of Triampherene
Megaloblastic anemia
26
DOC for GTCS
Valproate
27
DOC for Absence seizure
Valproate
28
DOC for childhood Absence Sz
Ethosuximide
29
DOC for JME
Valproate
30
DOC for Focal Sz
**Car**bamazepine
31
MOA of Diazoxide
ATP sensitive **K+** channel opener
32
A/E of Diazoxide
Hyperglycemia
( D/t hyperpolarisation of Beta cell of pancrease which leads to decreased production of insulin )
33
DOC for Restless leg syndrome
Gabapentin
34
NMDA antagonist
Felbamate
35
AMPA antagonist
Per**ampa**nel
Tela**ampa**nel
Topiramate
36
MOA of Ezogabine/Retigabine
K+ channel opener
37
Which type CCB is Ethosuximide
T type
38
Doc for SVT/PSVT + Asthma
Verapamil
39
Doc for A/c Attack of long QT syndrome
MgSO4
40
MOA of Adenosine
Ach sensitive K channel Activation
Decrease HR
Decrease Conduction
41
Doc for SVT/PSVT
Adenosine
42
BlueMan syndrome seeen in
Amiodarone
43
BRAF inhibitors
Dabrafenib
Vemurafenib
44
Enzyme def. in Von Gierke's
G-6-Phosphatase
45
Enzyme def. in Pompes
Lysosoma α 1,4-1,6 glucosidase
(Acid maltase)
46
Enzyme deficient in Cori's/Forbes
Glycogen Debranching enzyme
47
Enzyme def in McArdles and Hers
McArdles - Msl **Glycogen** phosphorylase
Her's -Liver Glycogen phosphorylase
48
Enzyme def in Taruis
Msl PFK
49
Enzyme defect in Mapple syrup Urine d/s
Branched Chain alpha keto dehydrogenase (BCKDH)
50
A/e while using Beta blockers for glaucoma
Corneal hypoesthesia
Systemic side effects
51
A/e while using Sympathomimetics for glaucoma
Lid traction
CNS depression and apnea in children less than two
52
A/E while using PG analogue for glaucoma
Eyelash hypertrichosis
Macular edema
Iris pigmentation
Periorbital fat depletion
53
A/E while using miotics for glaucoma
Retinal detachment
Cataract
54
A/E while using CA inhibitor for glaucoma
Corneal edema
Systemic side effects
55
MOA of metformine
AMP kinase stimulation
Decrease insulin resistance
56
MOA of Pioglitazone
Activate transcription regulator PPAR-g
57
Drugs causing SIADH
Chlorpropamide
Oxcarbamazepine
Vincristine
SSRI
Cyclophosphamide
58
Doc for Actinomyces and Syphilis
Penicillin
59
Doc for Listeria
Ampicillin
60
Doc for Mastitis
Cloxacillin
61
Doc for SSI
Cefazolin (first generation)
62
Doc for Neisseria
Cefixime/Ceftriaxone
63
Doc for Lyme disease
Cefixime/Ceftriaxone
64
Doc for Enteric fever
Cefixime/Ceftriaxone
65
Doc for Pseudomonas
Ceftazidine
66
Doc for Enterobacter
Carbapenems
67
Doc for Acinetobacter
Carbapenems
68
Doc for Plague ; Tularemia
Streptomycin
69
Doc for Ricketsia
Tetracycline
70
Doc for cholera
Tetracycline
71
Doc for Atypical Pneumonia ; Mycoplasma
Macrolides
72
Doc for Chlamydia
Macrolides
73
Doc for Diphtheria ; Pertussis
Macrolides
74
Doc for Legionella
Macrolides
75
Doc for Burkholderia
TMP-SMX
76
Doc for Nocardia
TMP-SMX
77
Doc for Meningococcus
FQ
78
Doc for Anthrax
FQ
79
Doc for UTI
FQ
80
Doc for Travelers Diarrhoea
FQ
81
Doc for Cestodes
Praziquantel
82
Doc for Trematodes
Praziquantel
83
Doc for Liverfluke
Triclabendazole
84
Doc Nematodes
Albendazole
85
Doc for Hydatid cyst
Albendazole
86
Doc for Onchocerca ; Strongyloids
Ivermectin
87
Doc for Cryptosporidium
Nitazoxanide
88
Doc for Cyclospora ; Isospora
TMP - SMX
89
Drugs causing Gout
"CANT LEAP"
Cancer drugs (Cyclosporine)
Aspirin
Niacin
Thiazide
Loop Diuretics
Ethambutol
Alcohol
Pyrazinamide
90
New FDA approved drug for Duchenne MD
-Eteplirsen
-Casimersen
91
Enzyme defect in Phenylketonuria
Phenylalanine hydroxylase
92
Enzyme defect in Tyrosinemia Type 1(Tyrosinosis)
Fumaryl Acetoacetate Hydrolase
93
Enzyme defect in Maple syrup urine disease
BCKAD
94
Enzyme defect in Homocystinuria Type 1
Cystathione Synthase
95
Enzyme defect in Tyrosinemia Type 2
Tyrosine transaminase
96
Enzyme defect in Primary Hyperoxaluria
Alanine glyoxalate aminotransferase
(Defect in metabolism of **glycine**)
97
Selenocysteine
21st Aā
Co-translational modification
Analogue of **Cysteine**
Synthesisedvfrome **Serine**
98
Pauly's test done for detecting
**Histidine**
(Imidazole ring)
99
Sulfur test is used for detecting which aā
**Cysteine**
(Sulfhydryl gp)
100
Sakaguchi reaction is used to detect
**Arginine**
(Guanidine gp)
101
Xanthoproteic reaction is used to detect
Benzene ring of aromatic aā
102
Ninhydrin reaction is used to detect
Alpha amino acid
