Medicine - Respiratory Flashcards
(268 cards)
how can lung cancer be classified histologically? what % of total lung cancers are each of them?
- non-small cell lung cancer, 80%| - small cell lung cancer (SCLC), 20%
2 types of non-small cell lung cancer?
- squamous cell carcinoma| - adenocarcinoma (more likely in a non-smoker)
which type of lung cancer can give rise to paraneoplastic syndromes? how?
- SCLC| - the cells have granules which secrete neuroendocrine hormones
presentation of lung cancer?
NAME?
which lymph nodes are enlarged first typically in lung cancer?
supraclavicular ones
first line investigation in lung cancer? what are the findings?
NAME?
investigations in lung cancer?
NAME?
when is surgical management used in lung cancer? what types are there?
NAME?
management of SCLC? prognosis?
NAME?
palliative treatment options for lung cancer?
NAME?
complications of lung cancer relating to compression and hormone secretion?
compression: - recurrent laryngeal palsy- phrenic nerve palsy- SVCO- horner’s syndrome hormonal:- SIADH- cushing’s syndrome - hypercalcaemia - limbic encephalitis - lambert-eaton myasthenic syndrome
how can lung cancer cause nerve palsy? which nerves are commonly affected?
NAME?
presentation of SVC obstruction?
- facial swelling - difficulty breathing - distended veins in neck and upper chest- pemberton’s sign
what is pemberton’s sign? is it significant?
- raising the hands over the head causes facial congestion and cyanosis - medical emergency!
how can lung cancer cause horner’s syndrome?
pancoast tumour compressing the sympathetic ganglion
presentation of horner’s syndrome?
triad:- partial ptosis - anhidrosis- miosis
what is a pancoast’s tumour?
tumour in the apex of the lung
how can lung cancer cause SIADH? key finding on bloods?
- SCLC tumour secreting ectopic ADH| - hyponatraemia
how can lung cancer cause cushing’s syndrome?
SCLC secreting ectopic ACTH
how can lung cancer cause hypercalcaemia?
squamous cell carcinoma (non-SCLC) secreting ectopic PTH
describe limbic encephalitis
NAME?
pathophysiology of lambert-eaton myasthenic syndrome?
antibodies created against SCLC cells but which also happen to attack voltage-gated Ca channels in motor neurones
presentation of lambert-eaton myasthenic syndrome?
NAME?
top differential for lambert-eaton myasthenic syndrome?
- myasthenia gravis| - onset is more insidious and symptoms less pronounced in lambert-eaton