Anaemic state with presence of abnormally large RBC (high MCV in blood)
Abnormally large immature erythryoblast found in bone marrow
Megaloblast formation is caused by?
Vitamin B12 or Folate deficiency
Vitamin B12 and Folate are required for?
Deficiency of Vitamin B12 and folate causes?
Abnormal cellular maturation
Lack of vitamin b12 and folate affects cytoplasm how?
Cytoplasm to nucleus ratio becomes very high (stuck in growth phase)
Vitamin b12 and folate deficiency affects erythryoblasts how?
Erythryoblasts become large, oval-shaped with small immature nucleus
Megaloblasts causes __________ leading to macrocytic anaemia
Pernicious anaemia definition
Anaemia from an autoimmune disorder which targets gastric cells and reduced intrinsic factor, leading to vitamin B12 deficiency
Vitamin b12 deficiencies such as diet should not be confused with pernicious anaemia
Pernicious anaemia’s mechanism
- Body produces auto-antibodies against gastric cells in stomach
- Gastric cells have reduced synthesis of intrinsic factor
- Intrinsic factor required to bind with vitamin b12 for absorption by ileum.
Poor vitamin b12 absorptions leads to?
Pernicious anaemia is associated with?