Megaloblastic anaemia Flashcards Preview

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Flashcards in Megaloblastic anaemia Deck (13)
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1
Q

Macrocytic anaemia

A

Anaemic state with presence of abnormally large RBC (high MCV in blood)

2
Q

Megaloblast

A

Abnormally large immature erythryoblast found in bone marrow

3
Q

Megaloblast formation is caused by?

A

Vitamin B12 or Folate deficiency

4
Q

Vitamin B12 and Folate are required for?

A

DNA synthesis

5
Q

Deficiency of Vitamin B12 and folate causes?

A

Abnormal cellular maturation

6
Q

Lack of vitamin b12 and folate affects cytoplasm how?

A

Cytoplasm to nucleus ratio becomes very high (stuck in growth phase)

7
Q

Vitamin b12 and folate deficiency affects erythryoblasts how?

A

Erythryoblasts become large, oval-shaped with small immature nucleus

8
Q

Megaloblasts causes __________ leading to macrocytic anaemia

A

Dysplastic erythryopoiesis

9
Q

Pernicious anaemia definition

A

Anaemia from an autoimmune disorder which targets gastric cells and reduced intrinsic factor, leading to vitamin B12 deficiency

10
Q

Vitamin b12 deficiencies such as diet should not be confused with pernicious anaemia

A

True

11
Q

Pernicious anaemia’s mechanism

A
  • Body produces auto-antibodies against gastric cells in stomach
  • Gastric cells have reduced synthesis of intrinsic factor
  • Intrinsic factor required to bind with vitamin b12 for absorption by ileum.
12
Q

Poor vitamin b12 absorptions leads to?

A

Macrocytic anaemia

13
Q

Pernicious anaemia is associated with?

A

Glossitis