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Flashcards in Membranes and Transport Deck (12):
1

What are the 2 different types of Phospholipids? Give examples

Glycerophospholipids: Phosphatidylserine, Phosphatidylcholine
Sphingolipids: Sphingomyelin

2

Glycolipids: Structure and location

Sphingosine backbone and carbohydrate residues. Found in the outer leaflet of the lipid bilayer.

3

On which sheet of the Plasma membrane are Phosphatidylcholine, Glycolipids, and Sphingomyelin located? (inner or outer?)

On the outer side of the membrane.

4

On which sheet of the Plasma membrane are Phosphatydilserine, Phosphatydilinositol and Phosphatydillethanolamine located? (inner or outer)?

Inner side of the membrane

5

Niemann-Pick Disease

Caused by deficiency of Sphingomyelinase. Sphingomyelin is accumulated and causes enlarged liver, and spleen and causes neurological problems.
Also called "cherry red spot"

6

Glycocalix: definition and functions

It is a carbohydrate cell.
It's functions are: Protection, Cell adhesion and cell identification.

7

Erythroblastis fetalis

Disease in which incompatibility between the mother(Rh-) and the fetus blood (Rh+)

8

Spur cell Anemia

It is a type of hemolytic anemia. It is caused by high levels of cholesterol in RBC membrane. Decreases fluidity and flexibility of membrane.

9

What is Mimantine/Namenda?

Antagonist of Glutamate receptor used to treat Alzheimer's disease.

10

Is the ATP hydrolyzed in the ABC Transporters?

Yes, but it does not phosphorylate the protein. E.g.: glycoproteins.

11

Cystinuria

caused by a defect in the transport responsible for uptake of dimeric amino acid Cystein and the dibasic amino acids: Arg, Lys, and Ornithine. Result in the formation of Cysteine stones in the kidney.

12

Hartnup Disease

Caused by a defect in the transport of non polar Amino acids, specifically Trp. Transporter is found in the intestine and kidney primarily.
AKA Pellagra like dermatitis.