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Flashcards in MEN Syndromes Deck (15):
1

MEN syndromes

group of inherited disorders

proliferative lesions
-hyperplasia, adenomas, carcinomas

of multiple endocrine organs

2

MEN1

pituitary
parathyroid
pancreatic

3 Ps

3

MEN2A

parathyroid
medullary thyroid carcinoma
pheochromocytoma

2Ps

4

MEN2B

mucosal neuromas
mafranoid body habitus
medullary thyroid carcinoma
pheochromocytoma

1P

5

think MEN if

young age
multiple endocrine organ tumors
asymptomatic hyperplasia precedes tumor

more aggressive and recur**

6

wermer syndrome

MEN1

pituitary, parathyroid, and pancreas glands

7

MEN1 parathyroid

primary hyperparathyroidism

8

MEN1 pancreas

endocrine tumor of pancreas

aggressive with mets

multiple microadenomas throughout pancreas

often functional tumors - PP most common

9

MEN1 pituitary

most frequently - prolactinoma

10

gastrinomas in MEN1

commonly in duodenum

11

MEN1 mutation

menin
tumor suppressor gene

12

MEN2 mutation

RET protooncogene

GOF mutation on chromosome 10q11.2

13

sipple syndrome

MEN2a

pheochromocytoma, medullary carcinoma of thyroid, parathyroid hyperplasia

14

MEN2b

more aggressive and multifocal medullary thyroid cancers

and pheochromocytomas

no hyperPTH**

also - neuromas or ganglioneuromas (bumps on skin, oral mucosa, eyes, resp tract, GI tract

also - marfanoid habitus

15

RET on genetic testing

prophylactic thyroidectomy

almost all develop medullary carcinoma of thyroid