menopause Flashcards

(43 cards)

1
Q

when do you begin screening women for osteoporosis

A

healthy women by age 65

earlier if women smoke, drink, RA, hx of fractures, dz/meds that add to the risk, body weight less than 127

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2
Q

combo estrogen and progestin Hormone Therapy

increases risk of

but decreases risk of

A

increases risk of:

  • thromboembolic events
  • breast CA
  • CVD
  • stroke

decreases risk of

  • fractures
  • colon CA
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3
Q

what are some non-pharmacologic osteoporosis preventative measures that pts can take

A

exercise: weight bearing, resistance, walking, aerobics

nutrition:

increase Ca to 1200 mg/ day at age 50

increase Vit D to 800 at age 70

avoid:

smoking, ETOH

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4
Q

laboratory diagnosis of perimenopause

A

FSH > 25

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5
Q

what are the non-hormonal pharmacological treatments for the vasomotor sxs of perimenopause and menopause

A

SSRIs (esp. LD paroxetine)

SNRIs

centrally acting anti-epileptics (gabapentin, pregabalin, clonidine)

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6
Q

vaginal vault apical pelvic prolapse

A

enterocele

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7
Q

stage 1 pelvic organ prolapse

A

more than 1 cm from the hymenal ring (inside)

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8
Q

Hispanic women are more susceptible to ___

A

pelvic organ prolapse

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9
Q

stage 3 pelvic organ prolapse

A

beyond 1 cm past the hymenal ring but still in vagina

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10
Q

what type of hormone therapy do you give

to a woman who has

undergone a hysterectomy

A

estrogen only

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11
Q

posterior compartment pelvic prolapse

A

rectocele

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12
Q

why is progestin added to estrogen in Hormone Therapy for women with a uterus

A

to decrease the risk of endometrial hyperplasia and endometrial CA

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13
Q

what type of hormone therapy do you give

to a woman who

still has an intact uterus

A

combo estrogen and progestin

(b/c unopposed estrogen with a uterus can cause endometrial hyperplasia and increase the risk of endometrial CA)

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14
Q

what are the components of the genitourinary syndrome of menopause

A

vulvovaginal atrophy (dryness, itching, dyspareunia)

sexual dysfunction

urinary frequency

recurrent bladder infections

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15
Q

white women and menopausal side effects

more susceptible to ___

A

osteoporosis

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16
Q

DEXA T score’s:

normal

osteopenia

osteoporosis

A

normal = - 1 +

osteopenia = - 1 to - 2.5

osteoporosis = less than - 2.5

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17
Q

when treating a patient w/ systemic hormone therapy,

what should the dose be?

for how long should they take it?

A

lowest effective dose

for the shorterst duration needed

(generally not more than 5 years or beyond 60)

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18
Q

how do you treat the sexual dysfunction sxs of postmenopause

why would not give everyone this (side effects)?

A

testosterone

but

side effects: lipids, clitoromegaly, hirsutism, and acne

19
Q

risk factors for pelvic organ prolapse

A
  • vaginal deliveries
  • advanced age/ menopause
  • obesity
  • CT disorder
  • chronic dz (constipation/ COPD)
  • Hispanic
20
Q

stage 4 pelvic organ prolapse

A

beyond the vagina

21
Q

asian women and menopausal side effects

more susceptible to ___

less susceptible to ___

A

more susceptible to osteoporosis

less susceptible to vasomotor sxs

22
Q

how often do you monitor osteoporosis once you begin?

A
  • normal BMD- Q 5 to 15 years
  • osteopenia (-1.5 to -1.99)- Q 5 years
  • osteopenia (-2 to -2.5)- yearly
  • osteoporosis- after tx Q2 years
23
Q

pelvic organ prolapse treatment

A

pessary

pelvic floor muscle exercises (kegels)

surgical tx (symptomatic/ refractory)

24
Q

what are the non-pharmacological treatments for the vasomotor sxs of perimenopause and menopause

A

lifestyle mods (layering clothes, avoid ETOH and caffeine)

exercise

phytoestrogens (soy, red clover)

herbal remedies (black cohosh, ginseng, ginkgo

vitamin E

accupuncture

** limited data for all of this **

25
how do you pharmacologically treat the vasomotor sxs of menopause (and perimenopause)
Hormone Therapy SSRIs and SNRIs clonidine gabapentin
26
pelvic prolapse where the uterus/ vaginal vault protrudes out of vagina
procidentia
27
disadvantages of pessaries
odor discharge vag ulcers erosion into bladder fistula formation ureteral obstruction w/ urosepsis or uremia small bowel prolapse and incarceration
28
stage 2 pelvic organ prolapse
from 1 cm before the hymenal ring to 1 cm beyond the hymenal ring
29
heaviness/ pressure/ pain/ irritation/ discomfort urinary incontinence/ retention defecation sxs feels like something is bulging outside of vagina
pelvic organ prolapse
30
what are the 3 types of pelvic organ prolapse surgeries
fixation to the sacrospinous ligament fixation to the uterosacral ligament sacrocolpopexy (fixation to the anterior longitudinal ligament)
31
how do you determine risk for osteoporosis related fracture
**FRAX score** 10 year risk assessment
32
when do you enter menopause
after 12 months without menstruation, avg age 51.5, younger than 40 is abnormal
33
osteoporosis diagnosis
DEXA (use T score to diagnose osteoporosis in post-menopausal women) or having fragility fractures (fractures that occur from a fall of standing height or less)
34
laboratory diagnosis of postmenopause
FSH \> 70
35
what are the routes of systemic Hormone Therapy
oral transdermal- patch/ gel/ spray
36
who gets osteoporosis tx
T score less than - 2.5 osteopenia + high risk postmenopausal + hx of hip/ vertebral fracture
37
**black women** and menopausal side effects more susceptible to \_\_\_ less susceptible to \_\_\_
more susceptible to **vasomotor sxs** (hot flashes) less risk of **osteoporosis and pelvic organ prolapse**
38
estrogen only Hormone Therapy increases risk of
**thromboembolic events** transdermal \> oral
39
osteoporosis pharmacologic tx
* **bisphosphonates- first line** * **dronates** * Selective Estrogen Receptor Modulators- also reduces risk of breast CA * raloxifene * Recombinant PTH- severe * teriparatide * Calcitonin- short term acute pain relief
40
vulvovaginal atrophy treatment
water soluble moisturizers and lube estrogen (topical \> oral) estrogen agonists and antagonists that selectively stimulate and inhibit different targe tissues (ospemifene)
41
how long does perimenopause last?
about 4 years til Final Menstrual Period (FMP)
42
anterior compartment pelvic prolapse
cystocele
43
contraindications for Hormone Therapy
breast CA CVD prior VTE/ stroke/ TIA active liver dz unexplained vag bleeding high risk endometrial CA