Menopause and Contraception Flashcards

1
Q

Name some symptoms of menopause.

A
Hirsuitism
Hot flushes
Memory loss
Irritability
Depression
Urogenital atrophy
Dry vagina
Mood swings
Menstrual irregularity
Sleep disturbances
Dry skin
Lack of concentration
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2
Q

What causes menopause?

A

95% of oestrogen’s produced in the body are oestradiol produced by granulosa cells in the follicle. This means when you run out of follicles there is a significant decrease in oestrogen.

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3
Q

What things are more or less likely with older oocytes?

A

Less likely to fertilise
Less likely to implant
More likely to miscarry
More likely to have chromosomal abnormality (due to nondisjunction)

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4
Q

What are long term problems caused by the menopause?

A

Osteoporosis
Dry vagina
Alzheimer’s (risk potentially increased by HRT)
Ischaemic heart disease (risk potentially increased by HRT)

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5
Q

Why is unopposed oestrogen not usually given as HRT?

A

It would potentially cause endometrial carcinoma, so unopposed oestrogen can only be given to women who have had a hysterectomy. Otherwise a combination of oestrogen and progesterone is given.

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6
Q

What are the benefits of HRT?

A
Relief of symptoms
Prevents osteoporosis
Reduces risk of colon cancer
Increased general wellbeing
Reduced cardiovascular disease risk, but only in YOUNGER women
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7
Q

What are some risks of HRT?

A

Increased risk of thrombosis and stroke
Increased risk of Alzheimer’s disease
Increased risk of cardiovascular disease in older women
Increased risk of breast cancer
Increased risk of endometrial carcinoma if given as unopposed oestrogen

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8
Q

What is premature ovarian failure?

A

Premature menopause (occurs before age 40). This can have a familial link or can occur as a result of iatrogenic factors e.g radiotherapy. There is a large impact on the patient’s mental health.

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9
Q

What are the three different types of causes for contraception to fail?

A
User failure
Method failure (e.g hole in the condom)
Provider failure (e.g clinician putting it in place causes it to fail)
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10
Q

What is shown by the Pearl Index?

A

The effectiveness of contraception

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11
Q

What is shown by UKMEC?

A

The medical eligibility criteria for contraceptive use, which shows the risk versus the benefit.

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12
Q

What are the three classifications of contraception?

A
Barrier contraception (e.g condoms)
Hormonal contraception (e.g COCP)
Other (e.g copper coil, emergency, surgical)
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13
Q

What are the advantages of condoms?

A

Protect against most STIs
Easy and cheap
Effective and straightforward to use
Rarely any side effects (unless latex allergy)

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14
Q

What are the disadvantages of condoms?

A
User failure can occur because they require planning and can be seen as interrupting sex
They can break or slip off (Method failure)
Not as effective as hormonal or intrauterine methods
Desensitises penis (which can be a positive thing in premature ejaculation)
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15
Q

What are the advantages of a femidom?

A

No side effects
Protects against some STIs
Can be used with oil based lubricants (unlike male condoms)
Thicker and less likely to tear than male condom
Can be left in place for up to 8 hours

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16
Q

What are the disadvantages of a femidom?

A
Not as socially acceptable
Insertion is fiddly and takes time
Can be noisy
Penis may go outside it (Method failure)
Inner ring can be uncomfortable
Not as effective as hormonal or intrauterine methods
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17
Q

What are the advantages of the diaphragm?

A
Can be inserted up to 3 hours before (but needs to be left for 3 to 6 hours after)
Rare side effects
Puts female in control
Not compromised by medication
Cheap as it can be washed and reused
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18
Q

What are the disadvantages of the diaphragm?

A

Low effectiveness (usually due to user failure on insertion)
Doesn’t give full protection against STIs
Can’t be used until 6 weeks post partum
Need to check it doesn’t have a hole in it
Increased risk of UTI
Can be affected by weight gain or loss
Relies on being kept in a safe place by the vaginal walls, so not as good for older patients with weaker muscles

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19
Q

How does the combined oral contraceptive pill work?

A

It contains oestrogen and progesterone, and so suppresses release of FSH and suppresses the mid-cycle LH surge. Its 3 main effects are:
It inhibits follicle development and ovulation
It inhibits implantation of the blastocyst into the endometrium
It thickens the cervical mucus

20
Q

What are the advantages of the COCP?

A

Effective
Easy to take - doesn’t interrupt sex
Reduces risk of benign great disease, ovarian cysts, ovarian cancer, endometrial cancer

21
Q

What are the disadvantages of the COCP?

A

Increased risk of cardiovascular disease and VTE

Mood swings, breast tenderness, and can cause bleeding

22
Q

What contraindicates someone for prescription of the COCP?

A

History of migraines (especially with aura), due to increased stroke risk
Family history of VTE or MI
Smoker, over 45, high BMI and blood pressure
History of malignancy, especially oestrogen dependent

23
Q

What are the side effects of hormonal contraception caused by oestrogen?

A

Fluid retention
Bloating
Breast tenderness
Nausea

24
Q

What are the side effects of hormonal contraception caused by progesterone?

A
Hirsuitism
Acne
Weight gain
Depression
Loss of libido
Vaginal dryness
25
Q

What do you need to do if you miss 2 or more pills in the first 7 days?

A

Use emergency contraception, and use other precautions (condoms) for 7 days.

26
Q

What do you need to do if you miss a pill in days 7 to 14?

A

Take the pill as soon as possible, and use other precautions for 7 days. You only need emergency contraception if 4 or more pills are missed in a row.

27
Q

What do you need to do if a pill is missed in days 14 to 28?

A

Omit the pill free week and start a new pack back to back, and use extra precautions for 7 days. Emergency contraception is only needed if you miss four pills in a row.

28
Q

What is the advantage of the combined contraceptive patch?

A

It stays on for a week at a time, so is good if the patient struggles to remember to take the pill.

29
Q

What are the disadvantages of the combined contraceptive patch?

A

It is expensive, and there is a risk of it falling off without the patient noticing.

30
Q

What is the disadvantage of the combined contraceptive vaginal ring?

A

More expensive than pill and can be difficult to insert.

31
Q

What are the three main effects of the progesterone only pill?

A

LH surge suppressed, so ovulation inhibited
Endometrium thin (due to no oestrogen), so implantation inhibited
Cervical mucus thickened so inhibits penetration by sperm

32
Q

What are the advantages of the progesterone only pill?

A

Doesn’t increase cardiovascular risk
Can be taken whilst breastfeeding
Easy to take

33
Q

What are the disadvantages of the progesterone only pill?

A

Breakthrough bleeding - erratic menstrual bleeding for a while)
Tiny window of error - must be taken in 3 hour window
Side effects associated with progesterone (acne, depression, weight gain, low libido, vaginal dryness, hirsuitism, irregular bleeding)

34
Q

How does the injection work?

A

It is progesterone based, given every 3 months.

35
Q

What are the advantages of the injection?

A

You don’t have to worry about remembering it every day

Low failure rate

36
Q

What are the disadvantages of the injection?

A

It has a long reversal time (up to 5 months)
Associated with progesterone side effects (menstrual irregularities, weight gain…)
Especially in women over 45 it can increase risk of osteoporosis, and of symptomatic ovarian cysts

37
Q

What are the advantages of the implant?

A

It is replaced every three years, so is useful for younger women who may be more erratic and have more problems with compliance.
It is effective and it is reversible.

38
Q

What are the disadvantages of the implant?

A

It is associated with progestagenic side effects like weight gain, irregular bleeding, acne, depression, headaches.

39
Q

What are the advantages and disadvantages of the copper coil?

A

Advantages:
It has no hormones (which makes it more attractive to some people)
It can be used as emergency contraception if it is inserted within 120 hours
It lasts 5 years
Disadvantages:
Insertion can be difficult and carries the risk of perforation
It causes heavy bleeding

40
Q

How does the IUD (e.g mirena) work?

A

It releases levenorgestrel, so releases progesterone on a more local basis.

41
Q

What are the advantages of the IUD?

A
Since the progesterone is released more locally it has fewer side effects
Effective
Convenient
Reversible
Reduces blood loss
42
Q

What are the disadvantages of the IUD?

A
The progestagenic side effects associated (although there is less systemic absorption so some are less severe):
Acne
Hirsuitism
Weight gain
Depression
Vaginal dryness
Menstrual irregularities
43
Q

Why is caution needed before carrying out female sterilisation?

A

It is permanent (there are risks associated with trying to reverse it, especially if there has been scarring), so you must ensure the patient definitely doesn’t want children in the future.

44
Q

How is female sterilisation done?

A

The fallopian tubes are cut, clipped or tied.

45
Q

How is male sterilisation done?

A

The vas deferens is cut (vasectomy)

46
Q

What are the types of emergency contraception?

A

Morning after pill and ulipristal (high dose progesterone)

Copper coil