Obesity Flashcards

1
Q

What seven things do food and eating contribute to?

A
Nutrition - keeping you alive
Identity
Social interaction
Politics
Economics
Socio-economic change
Environment - how and where food is grown and carbon footprint
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2
Q

What six things determine the choices we make about eating?

A

Rational health choices - which are affected by health promotion
Cost
Availabilty
Habit and custom, tastes
Sensuous gratification (fulfilling emotional needs)
Other emotional and relational needs (sharing food helps to cement relationships)

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3
Q

What are some social and cultural factors which put constraints on choice of food?

A

Religious beliefs
Political beliefs
Advertising and retailers
Your own tastes and what you like
Identity in terms of gender, class, ethnicity
Disease status e.g special diet needed for diabetes, coeliac…
Meanings of food
Time and ability to prepare and cook food

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4
Q

Why might advertisers use food to display emotions?

A

Food is a way to articulate emotions people may find hard to verbalise

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5
Q

How are patterns of food consumption distributed across the world?

A

In the west people spend a lot more money on food and eat more processed high fat high sugar food and less fresh fruit and vegetables.
In developing countries people tend to spend much less thank the west on food and eat a lot more seasonal fruit and veg and barely anything processed.

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6
Q

What is the difference between the way middle class families and working class families look at their eating habits and health.

A
Middle class families feel relatively secure, so are future orientated and think about their health a lot. Teenagers have less autonomy over their own eating.
In working-class families they are facing risks and insecurities and are more focussed on "here and now". Concerns about food, weight and health are less pressing than concerns about everyday health, and having enough food for today is a positive thing. Teenagers are given more autonomy over their eating which may mean bad choices.
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7
Q

What is food poverty?

A

A form of social exclusion which makes it hard for someone to obtain a nourishing diet, the inability to afford or access food to make up a healthy diet.

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8
Q

What are the consequences of food poverty?

A

Worse diet
Worse access to food
Worse health outcomes
A higher percentage of income is spent on food
Less choice from a restricted range of food
Less or no consumption of fruit and vegetables
30% of life years lost due to death and disability

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9
Q

What heath risks does food poverty contribute to?

A
Coronary heart disease
Cancer
Falls and fractures in older people
Low birthweight
Increased childhood morbidity and mortality
Increased dental caries in children
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10
Q

For what reasons do people access food banks?

A

No evidence that it is “because they are there”
Low income
Unemployment
Delays in benefits

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11
Q

What is hidden food poverty?

A

Not needing food parcels from food banks but still not eating well enough.

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12
Q

What are the 4 reasons for the increase in food poverty?

A

1) Decline of urban and rural public transport - car ownership is assumed to allow access to big shopping centres, this particularly affects older people and single parents with young children
2) Collapse of the independent food retail sector and supermarket expansion in urban and rural areas
3) Commercial incentive for food manufacturers to push high-fat high-sugar low-nutrition food, especially at the value for money end of the market
4) Low incomes, which make filling cheap foods with high fat content more attractive than fruit and vegetables

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13
Q

What is undernutrition/malnutrition?

A

Deficiency in one or more nutrients, resulting from a poor diet (especially a lack of fruit and vegetables).
Affects 2 million people in the UK, and about 40% of patients admitted to hospital are undernourished.
10% of people over 65 living in the community are undernourished.

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14
Q

What were the four findings of the Food Survey in the UK?

A

Average consumption of fruit and vegetables was half the recommended 5 a day.
Intake of non-milk extrinsic sugars (particularly among children) and saturated fats were above the maximum UK recommendations.
Evidence of inadequate nutrition status for iron, folate, vitamin D.
Substantial number of men and women were overweight or obese (obesity epidemic).

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15
Q

What are some of the factors in the aetiology of obesity?

A

Food intake, physical activity, food oversupply, price, culture, marketing, poor customer choice, genetic potential.

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16
Q

What are the three socio-economic factors that contribute to obesity?

A

1) Commercialisation of energy intake and energy expenditure - a lot of money to be made in food
2) Overproduction of food in capitalist economies
3) A focus on food consumption, not production or preparation
All of these contribute to all sorts of eating disorders.

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17
Q

What factor makes it hard for the WHO to be in an authoritative position compared to companies like Coca Cola and McDonald’s when it come to dialogue about food?

A

Coca Cola and McDonald’s each spend $1.7 billion annually, which is more than the total annual expenditure of the WHO on everything, worldwide.

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18
Q

What is the term given to the environment encouraging bad foot habits which is centred on sedentary lifestyles, fast and convenient food, advertising?

A

Obesogenic environment

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19
Q

What is the problem with downstream policy responses to the obesogenic environment?

A

Downstream responses are addressed to individuals, but this gives an ideology of choice and assumes too much agency for the individual who is usually facing necessity, not choice.

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20
Q

Why did the upstream policy responses to the obesogenic environment change from voluntary to legislative?

A

There was resistance from the food companies, they made voluntary pledges so no tougher rule would be legislated, then returned only limited action to reduce fat, salt, sugar levels. The action needed to be enforced so food companies couldn’t resist it.

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21
Q

Why was the 5 a day campaign called “political fudge”?

A

`the number selected was arbitrary, it was aspirational but not impossible to reach, it was thought if it was any higher people wouldn’t even try. There is only thin evidence provided that 5 a day actually does any good, and that the number doesn’t need to be higher.

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22
Q

What is evolutionary medicine?

A

Tries to find evolutionary explanations to vulnerability to disease, and why some diseases are still seen in high prevalence in the population - determines if there are selective advantages that predispose us to certain illnesses.

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23
Q

Why is sickle cell anaemia not selected against (since it is a deleterious genotype) in certain areas?

A

It has HETEROZYGOTE ADVANTAGE in areas where malaria is common, as having the heterozygote genotype affords some protection against malaria and the symptoms are less severe, which means it persists in the gene pool especially in areas like west Africa.

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24
Q

What is another example of heterozygote advantage (other than sickle cell anaemia)?

A

Cystic fibrosis (the gene causing the deleterious mutation in CFTR also provides protection against the pathogen responsible for typhoid fever - salmonella typhi, or may protect against the diarrhoea resulting from lactose intolerance so allows Europeans to drink milk)

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25
Q

What are some possible causes of the obesity epidemic?

A
Western high-energy diets, increased fat and sugar intake, super-sizing
Sedentary lifestyles
Sleep deprivation
Genetic predisposition
Endocrine (e.g thyroid) disorders
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26
Q

What two classifications can the causes of obesity be split into?

A

Proximate - lifestyle choices

Evolutionary - genetics

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27
Q

For what two types of selection could fatness have been selected in humans?

A

1) Natural selection - fatter individuals have greater survival chances
2) Sexual selection - fatness preferred in populations where food has traditionally been scarce (e.g Polynesia), people with more fat have a higher status and greater access to food

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28
Q

What are the three observations that the Thrifty Genotype hypothesis was based on?

A

Type 2 Diabetes runs in families
Type 2 diabetes rates are higher than expected for a deleterious condition in the general population
Some populations have a higher prevalence of Type 2 diabetes than others

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29
Q

What is the Thrifty Genotype hypothesis?

A

The genes that predispose people to Type 2 Diabetes enabled people in feast/famine environments to survive, and helped prevent muscle breakdown. This is because if the cells have insulin resistance then during famine they will take up less glucose so more remains to supply the brain so it will be longer before muscle is broken down to provide glucose for the brain. This is also combined with a predisposition for fat deposition so people have higher reserves when they enter famine in the first place.

30
Q

What are the three pieces of evidence FOR the Thrifty Genotype hypothesis?

A

In twin and family studies, a genetic component to Type 2 Diabetes has been found.
Modernised Pima in Arizona have higher rates of Type 2 Diabetes than those living a more traditional lifestyle.
A gene that is linked to low birth body mass, insulin resistance and diabetes is found in 10% of the British population but 100% of some Pacific island populations.

31
Q

What are the three pieces of evidence AGAINST the Thrifty Genotype hypothesis?

A

The hypothesis is very difficult to test.
Families tend to have the same lifestyle and diet and exercise habits, so there could be proximate factors affecting the whole family.
Traits running in families could be environmental or developmental (as in the Thrifty Phenotype hypothesis).
It would be expected that there was more insulin resistance in colder climates (due to higher latitudes being more seasonal), but actually Type 2 diabetes has higher incidence in more tropical populations.

32
Q

What is the Thrifty Phenotype hypothesis?

A

It argues that Type 2 Diabetes has an environmental rather than genetic basis.
If maternal nutrition is inadequate, then the foetus will divert nutrition to the brain at the expense of the other organs, and METABOLIC PROGRAMMING occurs so that the foetus can survive after birth in conditions of poor nutrition.
If the foetus is then relatively over nourished during its lifetime, there will be conflict between the metabolic programming and the experience and insulin resistance may develop.

33
Q

What are the four pieces of evidence FOR the Thrifty Phenotype hypothesis?

A

“Dutch Hunger Winter” - the babies that experienced poor nutrition in utero were more likely to have impaired glucose tolerance and diabetes than those in utero after the famine was lifted.
In monozygotic twins discordant fro Type 2 Diabetes, the twin with diabetes also had a significantly lower body mass at birth.
Rats with poorer nutrition in utero had worse glucose tolerance later in maturity than rats with normal foetal feeding.
In a modernising population, the maternal nutrition will improve over several generations so it would be expected that the mismatch in metabolic programming and experience would resolve and the prevalence of Type 2 diabetes would decrease.

34
Q

What are the three pieces of evidence FOR the Thrifty Phenotype hypothesis?

A

Hard evidence is needed that the low body mass at birth is directly related to maternal nutrition.
The theory, shown but the Dutch Hunger Winter and Leningrad Starvation Study, works better for males than females.
There is a possibility of confounding, and a gene actually exists which causes both lower birth mass and influences insulin resistance and Type 2 Diabetes.

35
Q

What is the Drifty Gene hypothesis?

A

The increase in obesity and Type 2 Diabetes are due to genetic drift, and advancing treatments have reduced the selection pressure so obese and diabetic people do not necessarily reproduce less.

36
Q

What condition other than Type 2 Diabetes can the Thrifty Genotype hypothesis be applied to, and why?

A

Gout. Gout is caused by a build up of uric acid, which is a product of the breakdown of fructose. Humans and primates lack the gene for the enzyme uricase, which breaks down uric acid. This is deleterious as it leaves them susceptible to gout, but it has been selected for because primates have a largely fruit-based diet which is very seasonal, and uric acid promotes the build up of fat which then increases chances of survival during the winter.

37
Q

Why does sleep loss increase hunger?

A

It leads to low leptin and high ghrelin, so acts on the hypothalamus.

38
Q

What are the four levels in the food pyramid from base to top?

A

Base = Carbohydrates (emphasis on starch and fibre)
Fruit and Veg
Meat and Dairy
Top = Fat, Oils, Sweets

39
Q

Why is the “healthy weight” BMI less prevalent for men than women?

A

Men have a much higher prevalence of “overweight”, even though women do actually have a higher prevalence of “obese”.

40
Q

How does the prevalence of child obesity change from reception to year 6?

A

Almost double to reach 19.2%

41
Q

What are 5 health consequences of obesity?

A

1) Massive increase in the risk of Type 2 diabetes
2) Increased risk of coronary heart disease
3) 10% increase in risk of non-smoking related cancers
4) Increased risk of premature death
5) Average decrease in life expectancy by 9 years

42
Q

How is BMI calculated?

A

Weight (Kg) / [height (m)]squared

43
Q

What are the categories related to BMI?

A

Underweight 25

Obese 30 40

44
Q

How is BMI applied to children?

A

Using growth percentiles

45
Q

What are the two types of obesity based on where the fat is put down?

A
Central obesity (apple-shaped)
Peripheral/gynoid obesity (pear-shaped)
46
Q

What are the waist sizes above which people have a very high risk of health problems due to central obesity?

A

Male > 102cm

Female > 88cm

47
Q

What are the 5 aspects of the metabolic syndrome (the metabolic syndrome is diagnosed by the presence of at least 3 of them)?

A

1) Abdominal/central obesity
2) Fasting hyperglycaemia
3) Hypertriglyceridaemia
4) Low HDL
5) Hypertension

48
Q

What is energy balance, and what does it mean when a person is in energy balance?

A

Energy balance is the difference between energy intake and energy output. A person in energy balance is maintaining their weight.

49
Q

What is positive energy balance?

A

The energy input is greater than the energy output, so there is an increase in the energy store in the form of carbohydrate, fat or protein.

50
Q

What is negative energy balance?

A

Energy input is less than energy output, so there is a loss in the energy store and you lose weight.

51
Q

Why is it difficult to measure energy intake in practise?

A

The standard methods suffer from recall bias, and problems can be caused if people get bored of writing down and weighing what they eat.
Food intake varies considerably on a daily basis and people have a tendency to under-report how much they have eaten.

52
Q

What are three methods for measuring energy intake?

A

Food diary and weigh all food/drink.
Food diary and estimate weight of food/drink.
Questionnaires asking for diet history and food frequency.

53
Q

Which part of the brain regulates appetite?

A

Hypothalamus

54
Q

Which neurones within the hypothalamus inhibit appetite?

A

Neurones releasing Melanocortin-Stimulating Hormone (aMSH), which acts on MC3 and MC4 receptors.

55
Q

Which neurones within the hypothalamus increase appetite?

A

Neurones releasing Neuropeptide Y, which acts on Y1 and Y5 receptors.

56
Q

Which hormones released by the gastrointestinal tract reduce appetite by inhibiting NPY?

A

CCK
Peptide YY
GLP-1
(also insulin reduces appetite)

57
Q

Which hormone reduces appetite by stimulating aMSH and inhibiting NPY?

A

Leptin secreted by adipose tissue.

58
Q

Which hormone increases appetite?

A

Ghrelin, secreted by the stomach.

59
Q

Which drugs prolong the effect of incretins (GLP-1) and so reduce blood glucose and are used to treat Type 2 Diabetes?

A

DPP-4 inhibitors (gliptins)

60
Q

Which system in the hypothalamus is affected by external factors (psychological, social, cultural signals) and can override the homeostatic system and increase appetite?

A

Hedonistic system.

61
Q

What are the three ways energy output can be measured?

A

1) Direct calorimetry
2) Indirect calorimetry
3) Doubly-labelled water

62
Q

What is direct calorimetry?

A

Measuring energy output by heat production from person in insulated box.
Very accurate but expensive and only useful in laboratory setting.

63
Q

What is indirect calorimetry?

A

Measuring energy output by measuring someone’s oxygen consumption, by measuring the CO2 content of their expired air. Only useful in a laboratory setting.

64
Q

What is the doubly-labelled water method?

A

The only free-living method to measure someone’s energy output.
Drink water enriched with 2H and 18O which are both harmless stable isotopes. Take a sample of saliva or urine each day. The 2H is only lost through water loss, but the 18O is lost through water loss and through being exhaled as CO2, so the difference in the loss of 2H and 18O shows how much CO2 has been produced which shows energy output.

65
Q

What are the three components of energy expenditure?

A

Basal metabolic rate = 65% of total energy expenditure
Thermal effect of food = 10% of total energy expenditure
Activity = fluctuating but can be about 25% of total energy expenditure

66
Q

What was the difference found between energy input and expenditure for obese people vs lean people?

A

The basal metabolic rate was similar for both groups, as the main metabolically active tissue is lean tissue like the liver.
Energy output was found to be higher in obese people than in lean people.
The lean group almost accurately recorded their energy input.
The obese group underestimated their energy input by an average of 835kcal a day.

67
Q

Why will some people find it harder to lose weight than others?

A

Normal variation in basal metabolic rate.

68
Q

Why might it be better to indirectly measure activity levels over time, e.g by measuring number of hours of television viewing?

A

It is difficult to non-invasively measure activity over time.

69
Q

What are three reasons it is very easy to overeat fat?

A

It’s highly palatable.
It is very energy-dense.
It is the least satiating nutrient.

70
Q

In what three ways does the food industry contribute to rising obesity levels?

A

Sugar, fat, salt are cheap and make food palatable.
The top of the food pyramid is highly overrepresented in advertising, which is aimed at confectionary, ready meals, fast food.
The companies have a resistance to changing and possibly losing massive profits, and they have an influence on the government.

71
Q

What is responsible for the initial rapid weight loss when adopting a diet?

A

Depletion of glycogen stores from the liver (because glycogen is a complex chain molecule and so binds a lot of water).

72
Q

Why does the rate of weight loss decrease as the diet continues?

A

Fat starts to be lost, and fat contains very little water and is energy dense, so takes a lot of time to lose.