Mental Health & Developmental Disabilities Flashcards
Describe the drug characteristics of SSRIs
- rapidly absorbed
- hepatically metabolized
- absorption unaffected by ingestion of food
- long-acting
- propensity for discontinuation syndrome
Which SSRI has the most evidence with respect to the treatment of depression in children and adolescents?
Fluoxetine (Prozac)
Which SSRI has evidence of negative impact on the treatment of depression in children and adolescents?
Paroxetine (Paxil)
List some short-term side effects of SSRIs
- GI symptoms
- sleep changes (insomnia, somnolence, vivid dreams)
- restlessness
- headaches
- appetite changes
- sexual dysfunction
- increased agitation or impulsivity (behavioural activation)
What are more rare adverse effects of SSRIs?
- increased bleeding risk
- SIADH
- serotonin syndrome
List the features of serotonin syndrome
- mental status changes
- myoclonus
- ataxia
- diaphoresis
- fever
- autonomic dysregulation
What warnings exist for the use of Citalopram?
- use only in doses
What differentials should be excluded when assessing a patient with anxiety?
- ADHD
- depression
- bipolar disorder
- autism spectrum disorder
To increase tolerability of medication for anxious patients, what approach should be taken?
- start at lower doses
- titration upwards gradually
- provide psychoeducation regarding potential side effects and their usually transient nature
How should you manage a patient with symptoms or family history of bipolar disorder when considering SSRI initiation?
Refer to psychiatrist for further assessment, management, given risk for hypo mania with SSRI
List, in order of increasing half life, four SSRIs
- Fluvoxamine
- paroxetine
- Sertraline
- Escitalopram
- Citalopram
- Fluoxetine
What challenges do children with ADHD face, compared with children without ADHD?
- school difficulties
- lower self-esteem
- family stress
- psychiatric comorbidities
- poor social skills
- social isolation
- poor sibling relationships
- poor peer relationships
What are adolescents with ADHD at higher risk for, compared with children without ADHD?
- school failure
- poor social relationships
- motor vehicle collisions
- delinquency
- poor vocational outcomes
- experimentation with tobacco, alcohol, drugs, sex
- being cited for speeding or other traffic violations
What are some types of arrhythmic heart disease in children?
- long and short QT syndrome
- arrhythmogenic right ventricular cardiomyopathy
- Brugada syndrome
- WPW
Compared to the general population, what is the risk of sudden unexpected death in children on ADHD stimulant medications?
Same