metabolism 03- tca Flashcards
Where are pyruvate, fatty acids, and acetyl coA oxidized?
Mitochondria
Oxidation of pyruvate + FA , acetyl coA formation, and NADH and FADH2 are all connected in what way?
they are processes that take place in the mitochondria
They all can connect to CAC
Biological metabolic pathways for which CAC can be sttarted from
TAG degradation (b-oxidation –> acetyl coA)
Protein catabolism –> Amino acids can be transaminated, oxidized, to precursors
Glycolysis (self explanitory)
Biosynthetic pathway citrate can feed into
fatty acid and sterol synthesis
biosynthetic pathway a-ketoglutarate can feed into?
Amino acid generation, neurotransmitter generation
Succinyl coA can be used to synthesize what?
Heme
Malate can be used in what biosynthetic pathway?
Gluconeogenesis
OAA can be used in what synthetic pathways?
AA synthesis
Gluconeogenesis
Fatty acid synthesis
CAC intermediates which can be used as precursors to biosynthetic pathways (5, does not include acetyl CoA)
Citrate A-Ketoglutarate Succinyl CoA Malate Oxalocetate
Glutamate can replace what citric acid cycle intermediate?
Alpha-ketoglutarate
Propionyl CoA can be used to replace what CAC intermediate
Succinyl CoA
Amino acids such as phenylalanine, tyrosine, and aspartate can replace what CAC intermediates?
Fumarate
Aspartate can replace what CAC intermediate
Oxaloacetate
Key regulatory enzymes of the citric acid cycle
Isocitrate Dehydrogenase
Alpha-ketoglutarate dehydrogenase
Activators and inhibitors of isocitrate dehydrogenase
Acitvated by ADP
Inhibited by ATP and NADH
