Metabolism Flashcards
(6 cards)
1
Q
Site of metabolism
A
Liver
2
Q
First pass metabolism
A
- Metabolism that occurs directly following absorption from the gut
- Drug delivered to systemic circulation via liver
3
Q
Phase 1 metabolism
A
CP450 mediated
Responsible for phase 1 oxidation
4
Q
Consequence of extensive first pass
A
Less drug reaches systemic circulation
Less drug absorbed
Low bioavailability
5
Q
CP450 structure
A
Haem subunit in active site
Fe II/III coordination at active site
6
Q
Avoiding first pass effect
A
IV IM inhaled sublingual buccal nasal rectal- enemas prodrug topical- patches, ointment vaginal pulmonary- aerosol, nebuliser
