Metabolism Flashcards

(44 cards)

1
Q

What is metabolism and why does it occur?

A

-Chemical reactions that take place in cells, and therefore in the organism of which the cells are part of
-Keeps the organism alive
-Concerned with maintaining a balance between energy release and energy utilisation

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2
Q

What 2 types of chemical reactions is Metabolism made up of?

A

-Catabolic
-Anabolic

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3
Q

What is ‘Catabolic Metabolism (Catabolism)’?

A

The reactions in which large molecules are broken down to smaller ones (catabolism), e.g. digestion
-Release energy

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4
Q

What is ‘Anabolic Metabolism (Anabolism)’?

A

The reactions in which small molecules are built up into larger ones (anabolism), e.g. protein synthesis
-Require energy

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5
Q

What is a ‘Nurtient’?

A

Any susbatance in food that is used for growth, repair or maintaining the body; that is, any substance required for metabolism

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6
Q

Name the 6 groups of nutrients?

A

-Water
-Carbohydrates
-Lipids
-Proteins
-Minerals
-Vitamins

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7
Q

What is an ‘Organic Compound’?

A

Molecules that have a carbon chain. They also contain a number of hydrogen atoms and can include atoms of oxygen, nitrogen or sulfur.

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8
Q

What are ‘Carbohydrates’?

A

-Main source of energy for cells
-Simple sugars (monosaccharides), particularly glucose, are used in cellular respiration to release energy
-Simple sugars can join together tof orm larger molecules (disaccharides)
-Complex carbohydrates, such as starch, are broken down to simple sugars
-All contain atoms of carbon, hydrogen and oxygen
-Polysaccharides are larger carbohydrate molecyles formed when many simple sugards join together

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9
Q

What are ‘Lipids’?

A

-Include fats and oil (broken down into fatty acids and glycerol)
-Important source of energy
-Gylcerol is broken down to release energy in a similar way to glucose
-Each lipid molecule consists of glycerol and one, two or three fatty acid molecules

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10
Q

What are ‘Proteins’?

A

-Organic compounds that are made up of many amindo acids (an amino acid is a molecule that contains an amino group and a carboxylic acid group)
-Two amindo acids bond together forming a peptide bond, releasing a water molecule
-20 different amino acids found in proteins, each one differening in the structure of the side chain
-Proteins consist of 100 or more amino acids; their type and order are determined by DNA, each protein has a characteristic shape due to the folding of the chain
-Shorter lengths of amino acids include dipeptides and polypetides

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11
Q

Name two other organic compounds (nucleic acids)

A

-Ribonucleic Acid (RNA)
-DNA

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12
Q

What are ‘Inorganic Compounds’?

A

-Not based on a carbon chain
-Do not contain carbon atoms, but those that do (e.g. CO2) are small molecules

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13
Q

Why is ‘Water’ important in metabolism?

A

-It is the fluid in which other substances are dissolved
-Some cellular chemical reactions occur in water
-Some water molecules take part in chemical reactions

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14
Q

Why are ‘Minerals’ important for metabolism?

A

-They may be part of enzymes
-Function as cofactors for enzymes
-Be part of substances such as adenosine triphosphate (ATP) that are involved in metabolism

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15
Q

Why are ‘Vitamins’ important in metabolism?

A

Act as coenzymes for many of the chemical reactions of metabolism

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16
Q

What are ‘Enzymes’?

A

-Biological catalysts that are able to speed up chemical reactions by lowering activation energy
-Not consumed or altered in reactions

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17
Q

What is the molecule called on which an enzyme acts?

A

Substrate - each enzyme will combine wuth only one particular substrate so is involved in only one specific reaction

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18
Q

What is the part of the enzyme molecule that combine the substrate and enzyme?

19
Q

When the enzyme and substrate are combined, what are they called?

A

Enzyme-substrate complex

20
Q

Whata re the two models to describe enzyme action?

A

-Lock and key model
-Induced fit model

21
Q

What is the ‘Lock and Key Model’?

A

States that shape of the enzyme (they key) is always complementary to the shape of the substrate (the lock). Therefore, the two will fit exactolyt to form the enzyme-substrate complex.

22
Q

What is the ‘Induced Fit Model’?

A

States that when the enzyme and substrate jon, they form weak bonds that cause the shape of the enzyme to change, creating complementary shapes

23
Q

How does the concentration of an enzyme affect acivity?

A

The higher the concentration of an enzyme, the faster the rate of a chemical reaction becuase there are more enzyme molecules to influence reactants
-Body is able to regulate type and number of enzymes to contro, which reactions occyr and the rate at which they proceed

24
Q

Why do the products of a reaction need to be continually removed?

A

To ensure the rate of reaction stays fast as it will become slower as it is more difficult for the substrate molecules to make contact with the enzyme molecules if there is more product

25
How does temperature influence enzyme activity?
-Most enzymes will increase in activity/effectiveness within a limited temperature range -Beyond 45-40°C they denature (enzymes are proteins) -Optimum temp. for most enzymes in the human body is 30-40°C
26
Does pH affect enzyme acitivity?
Yes, they are very sensitive to the pH of the medium in which the reaction is taking place (each enzyme has an optimum pH)
27
What do cofactors do and what are cofactors?
-Ions or non-protein molecules -Cofactors change tha shape of the active site so that the enzyme can combine with the substrate (without a cofactor, an enzyme is intact, but cannot function)
28
Why are enzyme inhibitors important in cells?
Allow cells to control reactions so that products are produced in specific amounts (e.g. pencillin is a durg enzyme inhibitor)
29
What is 'Cellular Respiration'?
-the process by which organic molecules, taken in as food, are broken down in the cells to release energy for the cell's activities
30
What can cellular respiration release energy from?
-Glucose (main) -Amino Acids -Fatty Acids -Glycerol
31
Is the breakdown of glucose to CO2 controlled?
Yes, it involves 20+ seperate reactions, which occur in a series, releasing small amounts of energy as the reactions proceed, ensuring a controlled release of energy
32
What percentage of available energy in cellular respiration is lost as heat?
60%
33
What is the remaining energy used to form in cellular respiration?
ATP, Adenosine Triphosphate - composed of three phosphate groups and adenosine
34
What is 'Glycolysis'?
-The first phase in the breakdown of glucose, 'splitting glucose' -Does not require oxygen -A glucose molecule is broken down in a series of 10 steps, to two molecules of pyruvate
35
What is 'Anaerobic Respiration'?
-If no oxygen is available, pyruvate is converted to lactic acid by fermentation -Fermentation stage does not procued additional ATP, however the glycolysis of one molecule of glucose releases enough energy to convert two molecules of ADP to ATP (allows cells to produce some energy without oxygen) -Enzymes necessary are found in the cytosol of the cell -Occurs in the cytosol of the cell -Important during vigorous physical activity
36
What is 'Aerobic Respiration'?
-Complete breakdown of the pyruvate (from glycolsis) to CO2 and H2O (respiration requiring oxygen) -Occurs in the mitochondria of the cell (two pyruvate molecules must enter the mitochondrion)
37
What is the sequence of events in 'Aerobic Respiration'?
1. pyruvate is converted to acetyl coenzyme A (acetyl CoA) 2. The acetyl CoA then enters the Kreb Cycle, here the carbon atoms are realsed in CO2 (for every acytyl CoA that enters the Kreb Cycle, one molcule of ATP is produced) 3. Electron transport system; the only stage that uses oxygen. Electrons are passed between molecules, finally resulting in oxygen molecules forming in H2O. Estimated 26-36 ATP molecules are produced.
38
How much ATP can one molecule of glucose potentially generate in Aerobic Respiration?
Up to 38 molecules
39
State some of the process why cells may need to access the energy stored in ATP molecules
-Building complex molecules -Cell divison and growth -Movement of cell organelles -Movement of whole cell -Maintaining cell organisation -Active transport -Transmission of nerve impulses
40
How much of the energy released during cellular respiration is incorporated into ATP and lost as heat?
ATP - 60% Heat - 40%
41
What is the role of DNA?
Stores inherited genertic information and controls protein synthesis
42
What is the role of RNA?
Carries genertic information from DNA to ribosombes where proteins (and enzymes) are produced for metabolic functions.
43
What is the 'Active Site'?
A specific region on the enzyme where a substrate binds; it is complementary in shape to the substrate
44
Why is energy released in a controlled manner during cellular respiration?
To avoid a sudden burst of energy and allow efficient ATP production. This is achieved through a series of over 20 small reactions.