Metabolism Flashcards Preview

Integrated Drug Structure, Action, and Therapeutics > Metabolism > Flashcards

Flashcards in Metabolism Deck (16):
1

Good with other drugs

Pramipexole

2

Use CYP 1A2/interact with fluvoxamine

ropinirole
rasagiline
ramelteon
tasimelteon

3

Use P450

Selegiline

4

Use 3A4

buspirone
alprazolam
suvorexant
eszopiclone
triazolam
midazolam
tasimelteon

5

Use NADH

chloral hydrate

6

Requires tests: liver monitoring

Tolcapone

7

Uses 2C19

carisprodol to meprobate
ramelteon

8

Which drugs interact with fluvoxamine?

Those that use 1A2 or 2C19

9

Which use glucuronidation to inactivate?

oxazepam
rotigotine
midazolam
alprazolam
lorazepam
oxazepam

10

Which drugs don't use metabolites?

oxazepam
lorazepam

11

Which drug can you detect using hair follicles?

clonazepam

12

Which drug interacts with cimetidine?

zaleplon

13

Which drug uses ester hydrolysis to inactivate?

flumazenil

14

Which drugs interact with AAAD?

L-dopa uses
carbidopa inhibits peripherally

15

Which drugs inhibit COMT?

tolcapone
entacapone

16

Which drugs use MAO-B?

MPTP
selegiline (inhibits)
rasagiline (inhibits)