MHC Structure and Function 1

Question 1

What was MHC first recognized for?

Answer 1

its role in self/nonself discrimination and transplant rejection

Question 2

What is MHC? What does it do?

Answer 2

Cell surface glycoproteins that bind antigens and “display” them on the host cell surface for recognition by T cells

Question 3

All of our MHC is

Answer 3

different

different shapes

Question 4

What does an individual’s MHC define?

Answer 4

Their susceptibility to disease

Tendency to autoimmunity and allergies

Question 5

How many classes of MHC are there?

Answer 5

3

Question 6

MHC class 1 function

Answer 6

Presentation of cytosolic antigens to cytotoxic T cells (within the cell) KILLER

Question 7

Where does MHC 1 function?

Answer 7

within in the cell

Question 8

MHC class 2 function

Answer 8

Presentation of extracellular/vesicular AG to helper T cells (outside the cell)

Question 9

Where does class 2 function?

Answer 9

Outside the cell

Question 10

What type of genes are MHC?

Answer 10

Polygenic

Question 11

Which chromosome is the MHC gene complex in humans? Mice?

Answer 11

Chr 6

Chr 17