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1 STEP Cardio pathology > MI complications 12/04 > Flashcards

MI complications 12/04 Flashcards

(37 cards)

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1
Q

0-4h gross change?

A

None

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2
Q

0-4h microscopic changes?

A

none

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3
Q

4-24 h gross change?

A

dark discoloration

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4
Q

4-24 h microscopic change?

A

COAGULATION NECROSIS.
Edema, hemorrage, WAWY fibers,
hypereosinophilic myocytes, shrunken nuclei.
Start to migrate neutrophils

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5
Q

None changes?

A

0-4h

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6
Q

dark discoloration?

A

4-24 h

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7
Q

COAGULATION NECROSIS.
Edema, hemorrage, WAWY fibers,
hypereosinophilic myocytes, shrunken nuclei.
Start to migrate neutrophils

A

4-24 h

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8
Q

0-4h/4-24 complications?

A

Cardiogenic shock (in massive MI>50proc sienos), Arrhytmia, CHF

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9
Q

Cardiogenic shock (in massive MI>50proc sienos), Arrhytmia, CHF

A

0-4h/4-24 complications

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10
Q

1-3 days gross?

A

yellow pallor/hyperemia

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11
Q

yellow pallor/hyperemia

A

1-3 days gross

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12
Q

1-3 days microscopy?

A

Extensive coagulation necrosis.
NEUTROPHIILS AROUND THE MI ZONE (infiltrate at the border zone). Occurs due to proinflammatory cytokines. Eventually migrate to center of MI.
Neurophils release lysosomal enzymes, ROS, cytokines.

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13
Q

Extensive coagulation necrosis.
NEUTROPHIILS AROUND THE MI ZONE (infiltrate at the border zone). Occurs due to proinflammatory cytokines. Eventually migrate to center of MI.
Neurophils release lysosomal enzymes, ROS, cytokines.

A

1-3 days microscopy

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14
Q

1-3 days complications

A

Fibrinous pericarditis (chest pain and friction rub)

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15
Q

Fibrinous pericarditis?

A

1-3 days complications

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16
Q

3-10 days gross?

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A

Hyperemic border, central yellow/brown softening

17
Q

Hyperemic border, central yellow/brown softening

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A

3-10 days gross

18
Q

3-10 days microscopy?

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A

MARCOPHAGES INFILTRATE:
- phagocyte dead myocytes and neutrophils

on 7th day START GRANULATION TISSUE WITH NEOVASCULARIZATION by IL10 and TGF-beta

19
Q

MARCOPHAGES INFILTRATE:
- phagocyte dead myocytes and neutrophils

on 7th day START GRANULATION TISSUE WITH NEOVASCULARIZATION by IL10 and TGF-beta

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A

3-10 days microscopy

20
Q

3-10 days complications

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A

Rupture of free ventricular wall -> tamponade
Rupture of interventricular septal wall -> shunt
Rupture of papillar muscle -> mitral insufficiency
LV pseudoaneurysm -> risk of rupture

21
Q

Rupture of free ventricular wall -> tamponade
Rupture of interventricular septal wall -> shunt
Rupture of papillar muscle -> mitral insufficiency
LV pseudoaneurysm -> risk of rupture

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A

3-10 days complications

22
Q

Rupture of free ventricular wall -> tamponade

23
Q

Rupture of interventricular septal wall -> shunt

24
Q

Rupture of papillar muscle -> mitral insufficiency

25
LV pseudoaneurysm -> risk of rupture
3-10 days
26
What predisposes interventricular rupture? what process?
Macrophage-mediated structural degradation
27
10-14 days microscopic?
VESSELS:Neovascularization of granulation tissue (most prominent on 10-14 days), FIBROBLASTS proliferation, COLLAGEN (type III).
28
Neovascularization of granulation tissue (most prominent on 10-14 days),, fibroblast proliferation, collagen (type III).
10-14 days microscopic
29
10-14 days gross?
red border emerges as granulation tissue enters from the edge of infarct.
30
red border emerges as granulation tissue enters from the edge of infarct.
10-14 days gross
31
2 weeks to 2 months microscopy?
(AKA FIBROSIS) Collagen remodeling and fibroblast differentiation into myofibroblasts drive the formation of scar tissue.
32
Collagen remodeling and fibroblast differentiation into myofibroblasts drive the formation of scar tissue.
2 weeks to 2 months microscopy
33
2 months post MI and more
(AKA FIBROSIS) remodeling continues to a slower rate as scar matures and contracts. (contracted scar is mature) collagen type III and I --> then only I in final stage
34
(AKA FIBROSIS) remodeling continues to a slower rate as scar matures and contracts.(contracted scar is mature)
2 months post MI and more
35
Gross when fibrosis starts (from 2 weeks to months)
white scar In final - type I collagen
36
2 weeks to 2 months complications
Dresslen syndrome -> results in fibrinous pericarditis True ventricular aneurysm -> risk of mural thrombus HF Arrhythmias
37
Dresslen syndrome -> results in fibrinous pericarditis True ventricular aneurysm -> risk of mural thrombus HF Arrhythmias
2 weeks to 2 months complications

1 STEP Cardio pathology (8 decks)

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