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Medical Microbiology > Microbial Immune Evasion Mechanisms > Flashcards

Microbial Immune Evasion Mechanisms Flashcards

(51 cards)

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1
Q

What are the microbial components that drive the pathogenesis of disease?

A
  • Adhesins
  • Toxins
  • Capsules
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2
Q

What are the properties of the host defensive mechanisms

A
  • Natural barriers
  • Defensive cells
  • Complement
  • immune response
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3
Q

What is virulence?

A

The degree to which a pathogen causes disease

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4
Q

What are the roles of virulence factors?

A

Colonisation and adhesion

  • Promoting adherence
  • Promote receptor binding
  • Promote internalisation of viruses
  • Allow bacterial colonisation of mucosal surfaces

Promote Tissue damage

  • Production of toxins and enzymes
  • pharmacological cytopathic action

Evade host defences

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5
Q

How does each pathogen evade the immune defenses?

A

There are over 300 human pathogens that are dealt with different immune mechanisms - each pathogen tries to evade different parts of innate immune system

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6
Q

How do bacteria evade the immune response?

A

Bacteria try to overcome the complement system

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7
Q

What are the roles of the complement system?

A
  • induces inflammatory response
  • promotes chemotaxis
  • ↑ phagocytosis by opsonisation
  • ↑vascular permeability
  • mast cell degranulation
  • lysis of cell membranes
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8
Q

How does the complement system achieve its roles?

A

Releases factors that chemo attract effector cells e.g. macrophages, neutrophils

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9
Q

How do bacteria overcome the complement system?

A
  1. Failure to trigger complement cascade -ve binding

2. Block/expel MAC

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10
Q

How do bacteria inhibit complement cascade activation?

A

LPS, capsules inhibit early stages of complement to bind to their surfaces

Stops assembly of complex on surfaces; Factor H sequestration

Coating with non-fixing IgA - can’t be opsonized

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11
Q

How do bacteria block macrophages?

A
  • Capsule blocks C3b binding (potent opsonin)
  • Capsule prevents C3b receptor access
  • C5a proteases (C5a is a chemoattractant factor)
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12
Q

Give examples of intracellular pathogens

A

Mycobacterium tuberculosis
Listeria
Salmonella

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13
Q

How do intracellular pathogens evade immune response?

A

Hidden from serum killing, complement, antibodies by hiding in a host cell

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14
Q

What are leukocidins?

A

cytotoxin created by some types of bacteria that forms pores in cells to kill them - cytopathic
e.g. Staphylococcus

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15
Q

How do intracellular pathogens prevent opsonisation?

A

Protein A (binds Fc portion of IgG)

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16
Q

How do intracellular pathogens block contact with immune cells?

A

capsules

meningococcus, Hib

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17
Q

Outline the immune evasion mechanisms in intracellular pathogens

A

promote own uptake (safe)
- CR3; mannose lectin receptors

Prepares cell for invasion: Shigella
-ve P-L fusion: M. tuberculosis
Escape P-L to cytoplasm: Listeria

Resist oxidative killing
Produce catalases/peroxidases

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18
Q

How does TB evade immune mechanisms

A

TB evades phagolysosome fusion
Remains as an early non-acidified vacuole in which bacteria can replicate to v. high no.’s and infect other cells to cause disease

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19
Q

Describe the characteristics of antibodies

A

Antibodies are antigen specific, high affinity

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20
Q

How do antibody-antigen complexes work?

A

Fc receptors (on macrophage) bind to a bacteria Fc component

Bateria is internalised and killed due to antibody generation

> Fc receptor mediated phagocytosis

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21
Q

How do pathogens evade Fc receptor mediated phagocytosis?

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A

Certain pathogens contain receptors on their surface that mimic Fc receptor of macrophages

22
Q

What is the consequence of Fc receptor containing pathogens?

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A

When antigen-specific antibodies are generated, bacterial Fc receptors bind them incorrectly so that antigen-antibody complex isn’t opsonized and killed - protective mechanism

23
Q

What are the key mechanisms of pathogens evading adaptive immunity?

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A
  • Concealment of antigen
  • Immunosuppression
  • Antigenic variation
  • Persistence/latency/reactivation
24
Q

How do pathogens conceal antigens to evade adaptive immunity?

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A
  • hide inside cells
  • privileged sites
  • block MHC antigen presentation
  • Herpes -ve TAP protein
  • surface uptake of host molecules
    e. g. CMV and beta2 microglobulin
25
How do pathogens evade adaptive immunity via immunosuppression?
↓ MHC, ↓ receptors, apoptosis, cytokine switch, IgA proteases
26
Outline paradigms of immune evasion
- Streptococcus pneumoniae - Neisseria gonorrhoeae - VZV and Herpes simplex - HIV - Influenza virus - Mycobacterium tuberculosis
27
What is the consequence of Streptococcus pneumoniae infection?
Causes inflammatory processes: septicaemia, meningitis, osteomyelitis
28
What is a commonly occurring illness of streptococcus pneumoniae?
Common cause of lobar pneumonia
29
What is lobar pneumonia?
Whole lower lobe of lung is completely infiltrated by inflammatory exudate pus
30
In a CXR why does the lower lung lobe appear opaque in lobar pneumonia?
Large numbers of organisms (shows up opaque on X-ray)
31
Outline the pathogenesis of pneumonia
1. Breath in Streptococcus pneumoniae 2. Colonised in nasopharynx due to their adhesin molecules 3. Secrete IgA proteases to stop immune mucosal surfaces from degrading them 4. Inhalation into lungs 5. Surfactant molecules overcome by pneumolysin production 6. Bacteria creates niche for own replication within lungs 7. Causes inflammation ⇒ pneumonia
32
Why do streptococcus pneumoniae infections develop into viral infections?
Streptococcus pneumoniae often followed by viral infections as defence mechanism structure of respiratory tract no longer intact (epithelial cell damage)
33
How does streptococcus evade immune response?
Streptococcus Pneumoniae evades inflammatory responses as it is capsulated: - Blocks antibody binding - Blocks complement binding - Blocks phagocytosis Gram +ve contain teichoic acids: pneumolysin
34
What is pneumolysin?
Pneumolysin is a toxin that lyses pneumocyte membranes
35
How does septic shock arise from pneumonia?
Pneumonia can spread from lungs into bloodstream ⇒ septicaemia, osteomyelitis, meningitis
36
Why does recovering from pneumonia not necessarily guarantee immunity?
Has multiple antigenic serotypes (slight changes in LPS capsule) to maximise survival within populations
37
What immune response is required for intracellular viral pathogens?
requires adaptive cell mediated immunity
38
How do viruses evade immune response?
1. Latency - VZV, herpes simplex 2. ↓ antigenic presentation by binding to TAP Inhibits peptide transfer to MHC Herpes simplex 3. ↓MCH expression - Cytomegalovirus (CMV) 4. Mutation of epitopes B cells - neutralisation escape T cells - CD8+ escape mutants of HIV
39
What phenotypic changes arise to cause antigenic variantions?
Phenotype changes - colony morphology, virulence, serotype, loose flagella, change surface sugars → Strategy for :- immune evasion and pathogenesis
40
What is antigenic diversity?
Genetically stable and alternative forms of antigens in a population of microbes e.g. serotypes of Strep.pneumoniae
41
What is antigenic variation?
Successive expression of alternative forms of an antigen in a specific clone or its progeny
42
What is phase variation?
ON/OFF of an antigen at low frequency
43
When does phase variation of a pathogen occur?
during course of infection in an individual host | during spread of microbe through a community
44
What is gonorrhoea?
a sexually transmitted disease
45
What are the signs of urethritis?
Discharge of pus, scanty to copious and purulent, Galen in 2ndC - “flow of seed”
46
What is urethritis?
Inflammatory and pyogenic infection of anterior urethra
47
What parts of the urogenital tract is affected by urethritis?
Infects mucosal surfaces with columnar epithelium | - urethra, cervix, rectum, pharynx, conjunctiva
48
What are the consequences of urethritis?
dysuria, redness, swelling, pain on urination, destruction of mucosa prostatitis, orchitis, strictures, ovaritis, fistulas, PID, proctitis, sterility
49
What are the effects of disseminated gonorrhoea infection?
Disseminated infections → arthritis, endocarditis, meningitis
50
How does variation arise in Neisseria Gonorrhoeae?
Bacteria; structures can undergo either: Phase variation i.e. an ON-OFF switch (capsule, Opa’s) Antigenic variation e.g. pilins (or both phase and antigenic)
51
How does influenza virus evade imunity?
Evades immunity at population levels: Antigenic drift – mutation + selection (Epidemics) Antigenic shift - gene reassortment (Pandemics)

Medical Microbiology (15 decks)

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