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Transition Block 1 2018/19 > Microbiology > Flashcards

Flashcards in Microbiology Deck (15)
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1

What is the gold standard investigation for suspected STI in a

a) man

b) woman?

a) First pass urine sample

b) Vulvourethral swab

both for chlamydial/gonococcal PCR

2

What are the antibiotics of choice for

a) chlamydia

b) gonorrhoea

c) bacterial vaginosis

d) trichomonas?

a) Doxycycline

b) Ceftriaxone

c) Metronidazole

d) Metronidazole

3

What are three subtypes of Chlamydia trachomatis which causes disease in men who have sex with men?

L1, 2 and 3

Lymphogranuloma venerum

4

Clue cells on microscopy is a finding in which condition?

Bacterial vaginosis

5

What is done after antibiotic treament for Neisseria gonorrhoeae infection?

Why?

Test of cure

Gonorrhoea is becoming resistant to all known antibiotics

6

What is adjuvant treatment alongside IM ceftriaxone for gonorrhoea in some trusts?

Oral azithromycin

7

Which organisms are targeted by

a) amoxicillin

b) metronidazole

c) gentamicin

in intra-abdominal sepsis?

a) Gram positives

b) Anaerobes

c) Coliforms

8

How is intra-abdominal sepsis treated?

Amoxicillin

Metronidazole

Gentamicin

9

What causes hypotension in septic shock?

Widespread inflammation => Leaky vessels => Fluid becomes "unavailable" in the interstitium

10

How does septic shock respond to fluids?

Reduced response

Because administered fluids escape through leaky vessels

11

Gentamicin toxicity damages which cranial nerve?

CN VIII - Vestibulocochlear nerve

Causing hearing loss and dizziness (vertigo)

12

What are the most common causes of bacterial meningitis?

Strep. pneumoniae - children and general population, give rifampicin as prophylaxis and benzylpenicillin + dexamethasone as treatment

Neisseria meningitidis - adolescents / young adults, give IV ceftriaxone + dexamethasone

Listeria monocytogenes - elderly & immunosuppressed + dodgy cheese

13

Which drug is often given alongside antibiotics in bacterial meningitis?

Dexamethasone

14

Listeria monocytogenese infection is associated with the consumption of what?

Soft cheese

Especially amongst pregnant women

15

Why is ceftriaxone chosen for empirical treatment for suspected bacterial meningitis instead of penicillin?

Ceftriaxone has a longer t1/2 than penicillin

So doses can be less frequent