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Transition Block 1 2018/19 > Immunology > Flashcards

Flashcards in Immunology Deck (10)
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1

In a patient who has a significantly high ANA titre, which autoantibody would you test for next?

Which CTD is this antibody associated with?

Anti-dsDNA

SLE

2

Which connective tissue disease are Anti-Ro and Anti-La associated with?

Sjogren's syndrome

3

Which connective tissue disease is Anti-Jo1 ​associated with?

Dermato/Polymyositis

4

Which connective tissue disease is Anti-centromere antibody ​associated with?

Limited systemic sclerosis

CREST symptoms

Complication: pulmonary hypertension

5

Which connective tissue disease is Anti-Scl70 antibody ​associated with?

Diffuse systemic sclerosis

Complication: pulmonary fibrosis

6

What are the CREST symptoms of limited systemic sclerosis?

Calcinosis

Raynaud's phenomenon

Oesophageal dysmotility

Sclerodactyly

Telangectasia

7

Which markers are used in the diagnosis of rheumatoid arthritis?

Inflammatory markers e.g CRP, PV

RF

Anti-CCP antibody

8

Name three small vessel vasculitidies.

Microscopy polyangiitis

Granulomatosis with polyangiitis (formerly Wegener's)

Eosinophilic granulomatosis with polyangiits (formely Churg-Strauss)

9

Which autoantibodies are associated with

a) Microscopy polyangiitis

b) GWP

c) EGWP?

a) p-ANCA

b) c-ANCA

c) p-ANCA

10