Microbiology/Immunology Flashcards
1
Q
What is the proposed cause of type 1 diabetes in terms of genetics, tolerance and inflammatory damage?
A
Big genetic predisposition; especially certain HLA haplotypes.
T cells escaping either central or peripheral tolerance and find their way to the pancreatic B cells
Launch attack, mainly Th1 and CD8
Perforin and granzymes involved in destruction
