"Microbiology/Immunology Antibody Structure & Function" SANA Flashcards Preview

Unit 6 > "Microbiology/Immunology Antibody Structure & Function" SANA > Flashcards

Flashcards in "Microbiology/Immunology Antibody Structure & Function" SANA Deck (22):
1

Which immunoglobin class is the heaviest?

IgM

2

Which Immunoglobin is primarily responsible for the neutralization and protection against foreign bodies?

IgG

3

IgM is often found as a ______ (organization)

Pentamer

4

True or false? The light chains and heavy chains are identical to each other

False, they are different but one light chain in an antibody is identical to another light chain in an antibody (same for heavy chains)

5

Where is IgA usually found?

In mucus membranes because it can transport across the epithelium

6

Which immunoglobin is usually responsible for allergic reactions?

IgE

7

IgE is responsible for the sensitization of ______

Mast cells

8

Which antibodies does the fetus get directly from its mother?

IgG because they can transport across the placenta

9

Which antibodies can diffuse into extravascular sites?

IgG

10

Which immunoglobin class is the most stable? What is its half life in serum?

IgG; about 3 weeks

11

True or false? IgG can directly kill a bacteria without a complement system.

False: IgG does not directly kill bacteria alone, it binds to it and, in the presence of a complement system, can kill it.

12

How do natural killer cells use antibodies to target a cell?

Using antibody dependent cellular cytotoxicity where antibodies direct the NK cell to the target

13

IgG can cause the clumping of bacteria. What is this called?

Agglutination

14

Why can't IgM aid in opsonization without the help of a complement system?

Because immune cells don't have IgM receptors

15

Which immunoglobin is crucial in EARLY immune response?

IgM, its found as antigen receptors on naive B-lymphocytes.

16

What is holding the IgM pentamer together?

The J chain

17

IgA is found mostly as ____

Dimers

18

What is a secretory piece?

A protein that wraps around the IgA molecule as it passes through the epithelial cell and keeps it from being hydrolyzed.

19

In what secretions is the IgA usually found?

Mother's milk, saliva, gut secretions

20

Where is the variable region found once the antibody has been cleaved? In the Fab region or the Fc region?

The Fab region

21

Why does the Fc region crystallize and not the Fab region?

The Fc region does not have a variable region and the structures can thus form crystals as they are constant to each other.

22

On which portion of the variable region of the antibody do the antigen bind?

The hypervariable region, which provides specific complementarity to the specific antigen.

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