Name the 2 classes of microtubule inhibitors. Are they cell cycle specific?
Vinca alkaloids and taxanes. CCS for M phase
Name the 2 vinca alkaloids, derived from the periwinkle plant.
Vinblastine and vincristine
Name the 2 taxanes, derived from yew trees.
Paclitaxel and docetaxel
To what cellular molecule do vinblastine and vincristine bind, and how do they inhibit microtubules?
Bind to tubulin, inhibit microtubule polymerization/assembly
To what molecule do paclitaxel and docetaxel bind, and how do they inhibit microtubules?
Bind to tubulin, inhibit microtubule depolymerization/disassembly
Which microtubule inhibitor is used to treat hematologic cancers like childhood ALL, Hodgkin’s disease, and non-Hodgkin’s lymphoma?
Which is the only microtubule inhibitor that does not cause peripheral neuropathy?
Which microtubule inhibitor is used in combination regimens for testicular cancer and Hodgkin’s disease?
Vincristine is used in association with what other compounds to treat childhood ALL?
Which microtubule inhibitor is used to treat hormone-refractory prostate cancer?
What is the major side effect of using vincristine, paclitaxel, and docetaxel?
Which class of microtubule inhibitors can be used to treat a variety of metastatic solid tumors, including breast, ovarian, lung, and head and neck cancers?
Which microtubule inhibitor has relatively low bone marrow toxicity?