Misc 2: Monoclonal Antibodies Flashcards Preview

Unit 1: Pharm > Misc 2: Monoclonal Antibodies > Flashcards

Flashcards in Misc 2: Monoclonal Antibodies Deck (16)
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1
Q

Name the four monoclonal antibodies.

A

Rituximab, trastuzumab, cetuximab, and ipilimumab

2
Q

What antigen does rituximab target, and what cancer is it therefore used to treat?

A

CD20 (B-cell antigen); Non-Hodgkin’s lymphoma

3
Q

What antigen does trastuzumab target, and what cancer is it therefore used to treat?

A

HER2/neu; HER2(+) metastatic breast cancer

4
Q

What antigen does cetuximab target, and what cancer is it therefore used to treat?

A

EGFR1; EGFR(+) metastatic colorectal cancer

5
Q

What cancer is ipilimumab used to treat?

A

Melanoma

6
Q

Which monoclonal antibody is associated with severe side effects such as interstitial pneumonitis, dermatological problems, renal failure, electrolyte abnormalities, and sudden cardiac death?

A

Cetuximab

7
Q

Name 2 important side effects of trastuzumab.

A

Hypersensitivity reactions and ventricular dysfunction

8
Q

What monoclonal antibody is usually combined with taxanes to treat breast cancer?

A

Trastuzumab

9
Q

Which monoclonal antibody requires careful monitoring because it is known to cause side effects such as infusion reactions, skin reactions, irregular heartbeats, tumor lysis syndrome (TLS), severe mucocutaneous reactions, and progressive multifocal leukoencephalopathy (PML)?

A

Rituximab

10
Q

Name 3 immune processes that are activated by the CD20 antibody rituximab.

A

Apoptosis, complement, and cell-mediated immunity

11
Q

Give 2 hypotheses for how trastuzumab modulates the HER2/neu receptor

A

Trastuzumab may enhance receptor endocytosis or block receptor dimerization

12
Q

Which monoclonal antibody stimulates the immune system by inhibiting CTLA4 (Cytotoxic T Lymphocyte Antigen 4)?

A

Ipilimumab

13
Q

Which monoclonal antibody inhibits the gene ErbB1?

A

Cetuximab

14
Q

Which monoclonal antibody, currently in clinical trials, will probably be used in combination with cisplatin?

A

Cetuximab

15
Q

Which monoclonal antibody can cause ventricular dysfunction and cardiotoxicity, especially when used in association with doxorubicin?

A

Trastuzumab

16
Q

Which monoclonal antibody can be used to treat non-Hodgkins lymphoma?

A

Rituximab