Misc 2: Monoclonal Antibodies Flashcards
Name the four monoclonal antibodies.
Rituximab, trastuzumab, cetuximab, and ipilimumab
What antigen does rituximab target, and what cancer is it therefore used to treat?
CD20 (B-cell antigen); Non-Hodgkin’s lymphoma
What antigen does trastuzumab target, and what cancer is it therefore used to treat?
HER2/neu; HER2(+) metastatic breast cancer
What antigen does cetuximab target, and what cancer is it therefore used to treat?
EGFR1; EGFR(+) metastatic colorectal cancer
What cancer is ipilimumab used to treat?
Melanoma
Which monoclonal antibody is associated with severe side effects such as interstitial pneumonitis, dermatological problems, renal failure, electrolyte abnormalities, and sudden cardiac death?
Cetuximab
Name 2 important side effects of trastuzumab.
Hypersensitivity reactions and ventricular dysfunction
What monoclonal antibody is usually combined with taxanes to treat breast cancer?
Trastuzumab
Which monoclonal antibody requires careful monitoring because it is known to cause side effects such as infusion reactions, skin reactions, irregular heartbeats, tumor lysis syndrome (TLS), severe mucocutaneous reactions, and progressive multifocal leukoencephalopathy (PML)?
Rituximab
Name 3 immune processes that are activated by the CD20 antibody rituximab.
Apoptosis, complement, and cell-mediated immunity
Give 2 hypotheses for how trastuzumab modulates the HER2/neu receptor
Trastuzumab may enhance receptor endocytosis or block receptor dimerization
Which monoclonal antibody stimulates the immune system by inhibiting CTLA4 (Cytotoxic T Lymphocyte Antigen 4)?
Ipilimumab
Which monoclonal antibody inhibits the gene ErbB1?
Cetuximab
Which monoclonal antibody, currently in clinical trials, will probably be used in combination with cisplatin?
Cetuximab
Which monoclonal antibody can cause ventricular dysfunction and cardiotoxicity, especially when used in association with doxorubicin?
Trastuzumab
