midterm 1 Flashcards by Cian Ryan

Which drugs are the absolute priority in the drugs cascade?

a. Human licensed medicine
b. official medicines
c. veterinary licenced medicines
d. prepared medicines for the certain individual animal

Veterinary licenced medicines

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two drugs have been examined in animal studies. Both have a therapeutic index of 2. it can be examined first?

a. when given in ED50 doses the safety of the two drugs is equal
b. when given in Ed50 doses no animals will be killed by the drus
c. dose response curves will be parallel
d. none of these answers are correct

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Which one is correct? when the pka of a drug equals to the pH of the enviroment?

a. Numbers of ionized and non ionized molecules is varying
b. Number of ionized molecules is higher
c. 50% ionizaton occurs
d. Number of non-ionized molecules is higher

50% ionization occurs

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Specific receptor antagonists can be best described as having?

a. affinity but little or no efficacy for the receptor
b. both efficacy and affinity for the receptor
c. efficacy but little or no affinity for the receptor
d. none of them

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This drug is most sensitive to air humidity , it causes significant degradation of the substance?

a. vaccines
b. silver containing products
c. clavulanic acid
d. vitamins

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In this type of prescription, the propietary name of the medicine is given?

a. prescription of an official medicine
b. prescription of an occasionally prepared(magistral) medicine
c. Prescription of official formulated medicine
d. Prescription of a veterinary authorized(licensed)medicine

Prescription of a veterinary authorized (licensced) medicine

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The function of TiO2 coating on the surface of tablets?

a. Protection against humidity
b. protection against light
c. lubricant
d. intestinosolvent layer

Protection against light

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What is the proportion of ionised and non ionised mlecules of a weak acidic drug(pka4.4)in milk(pH=6.4)?

a. 100:1
b. 1000:
c. 10:1
d. 1:1

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What is the characteristic for a drug molecule which has been metabolised which has been metabolised in the phase 2 biotransformation process?

a. Metabolitre with qualitatively different pharmacologic action
b. increased activity
c. active metabolite from an inactive prodrug
d. losing of activity

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The modified release solid dose forms can be prescribed using the following type of prescription?

a. Official
b. Prepared
c. all of these prescription types
d. licensed

c. all

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In this type of prescription the proprietary name of a veterinary licensed medicine is given?

a. Prescription of a formulated official medicine
b. prescrption of a veterinary authorized medicine
c. prescription of prepared(magistral) medicine
d. Prescription of a human authorized medicine

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The phenomeon in which two drugs produce opposite effects on a physiologic system but do not act on the same receptor is?

a. chemical antagonism
b. non competive antagonism
c. Physiologcal antagonis
d. competitive antagonism

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These drugs must not be used in food producing animals, therefore no MRL can be determined?

a. Drugs in table 1.(37/200/EC)
b. Drugs in tabe 2(37/2010/EC)
c. Both
d. none

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What is the difference in the composition between the mixed powders and he granules?

a. only the granules may have liquid materials in the ingredients
b. powders have adhesive material
c. granules usually have adhesive material
d. none of these

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What does the inscripton part of the prescription contain?

a. user information to the owner
b. number of packages to dispense
c. receipe which means to take
d. drug name strength dose forms

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The vd value of a drug is l/kg. the required plasma concentration to acheive a desired therapeutic response is 30mg/l. What is the loading dose for a dog with 5kg body weight?

a. 3g
b. 450 mg
c. 150 mg
d. 300 mg

450 mg

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A drug that interacts directly with the agonist and not at all,or onl incidentally with the receptor?

a. partial agonist
b. Physiological antagonists
c. chemical antagonist
d. pharmalogical antagonist

———– is the largest effect a drug can produce regardless of the dose?

a. quantal dose response curve
b. graded dose response curve
c. maximum efficacy
d. therapeutic index

The sugarpie

a. can e given mixed with fumagillin for honey bees against Nosemia apis
b. can be given mixed with amitraz for honey bees against varroa destructor
c. none of them
d. both

Which dimension is used when prescribing a solid component in a prescription?

a. ml
b. mol
c. gram
d. none of these

gram

which one is incorrect? factors facillating drug allergy are?

a. frequent contamination of the skin with the active substancs
b. inhalational of active substances contamination of airways
c. chronic disease atopy
d. prepartion with rapid absorption after im or Sc administration

A drug that interacts directly with the agonist and not at all, or only incidentally , with the receptor?

a. partial agonist
b. chemical antagonst
c. pharmalogical antagonist
d. physiologic antagonist

What is F value in pharmackinetics?

a. free fractions
b. bioavalailability
c. Bound fractions
d. bioequilavance

Bioavailability

What is the proportion of ionised and non ionised molecules of a weak acidic drug(pka=4.4)in blood(pH=7.4)?

a. 10;1
b. 100;1
c. 1000;1
d. 1;1

1000;1

which technology is appropriate for acheiving a pulsatile release of an active substance in an intraruminal bolus? ## Footnote a. Insoluble matrix b. oros c. chip controlled capsules d. expanding matrix

chip controlled capsules

which schedule of controlled drugs requires special prescription record keeping and keeping of relevant invoices for two years? a. schedule 3 b. schedule 4 c. schedule 5 d. schedule 2

schedule 5

This can be used as adhesive materials in the granules? ## Footnote a. silver nitrate b. ascorbic acid c. eucalyptus oils d. methylcellulose

In case of prescribing a multidose powder we declare he total amount of the ingredients required and after the mixing order we declare the number of doses the mixture should be divided. Which division method should be performed? ## Footnote a. Dispensatio method b. dividatio method c. either d. none

dividatio method

What does ADME stand for in pharmaoinetics?

Absorption, distribution, metabolism, excretion

Which of the followng can occur at therapeutic dosage levels in a healthy patients? a. idiosyncratic reactions b. Teratoenic studies c. allergic reactions d. all of them

all

Two drugs a and b have the same mechanism of action? Drug A in a dose of 5mg produces the same magnitude of effect as drug B in a dose of 500 mg? ## Footnote a. the toxicity of drug a is lower than that of drug b b. drug a has a shorter duration of action c. drug b is less efficacious than drug A d. Drug A is 100 times more potent than drug b

the plasma concentration of a drug at steady state(cpss) is 1mg/l. the total body clearance is 100ml/min, the elimination half time is 0.7hr. what is the maintenance dose if the drug i applied every 8 hr? ## Footnote a. 4.8 mg b. 6mg c. 0.6 mg d. 48mg

In this form of prescription, the veterinary practioners should always state the disease for which the formulation is ordered? ## Footnote a. special prescription b. prescription for medicated feedstuff(MFSP) c. Prescription d. legislation on requisition(written requisition)

This is obligatory for obaining schedule 2 and 3 drugs for use by a veterinarian in his own practice? a. legalisation on requisition(writtten resquition) b. label c. prescription for medicated feedstuff(pmf) d. veterinary record fr controlling drugs

What process can move drugs against a concentaryion gradient? a. filtration through membrane pores b. simple diffusion c. active transport d. faciltated diffusion

c. active transport

This is obligatory when drugs are supplied to owners by vets? ## Footnote a. prescription for medicated feedstuff(MFSP) b. Veterinary record for controlled drugs c. label d. legalisation on requisation(written requisation)

only veterinarians can prescribe this drug category? ## Footnote a. POM VPS b. AVM GSL c. POMV d. NFA VPS

the name is given by the international pharmacopoia commision and is mainly uniform worldwide? a. licensed name b. Propietary name c. approved name d. Brand name

Most frequently and the effect of the drug is preceeded by this interaction? ## Footnote a. Drug receptor interaction b. non specific chemical interaction c. antimetabolite action d. drug enzyme interaction

the phenomenon in which two drugs prodyc opposite effects on a physiological system but do not act at the same receptor is? ## Footnote a. competitve antagonism b. chemical antagonism c. physiolgical antagonism d. non competive antagonism