Midterm #1 Review Flashcards
(173 cards)
In your own words, describe the size, location, and orientation of the heart
- The heart rests on the diaphragm, near the midline of the thoracic cavity.
- It lies in the mediastinum- an anatomical region that extends from the sternum to the vertebral column, from the first rib to the diaphragm, and between the lungs
The orientation of the heart
- The heart looks like a cone lying on its side. The pointed apex is formed by the tip of the left ventricle and rests on the diaphragm. It is directed anteriorly, inferiorly and to the left.
- The base of the heart is its posterior surface. Formed by the upper chambers of the heart, mostly the left atrium.
List the 4 valves of the heart – include all alternate names for each valve.
1) Tricuspid Valve: blood passing from the right atrium into the right ventricle.
Also called the Right atrioventricular valve
2) Bicuspid Valve: blood passes from left atrium into the left ventricle
Called Mitral valve and Left atrioventricular valve
3) Pulmonary Valve: blood passes from the right ventricle into a large artery called pulmonary trunk. It divides into right/left pulmonary arteries, carries to lungs
Semilunar Valve
4) Aortic Valve: blood passes from left ventricle through this valve, into the ascending aorta
Semilunar Valve
Cardiac Output
The amount of blood pumped by the ventricle (either right or left) in one minute
Cardiac Output (CO) = Stroke Volume (SV) X Heart rate (HR)
Cardiac Output (CO) = 70 mL X 75 bpm
Cardiac Output (CO) = 5250 mL/minute OR 5.25L/minute
Stroke Volume:
The volume of blood ejected by the ventricle during one contraction
EDV - ESV
The volume of blood in the ventricle after relaxation
End Diastolic Volume (EDV)
The volume of blood remaining in the ventricle after it contracts
End Systolic Volume (ESV)
Cardiac Reserve
he difference in cardiac output from the maximum output ( activity) to the minimum output ( activity).
The difference is usually 5-4 times the resting, or minimum, output
Cardiac Cycle:
Includes all the events associated with one heartbeat.
- Consists of systole and diastole of the atria plus systole and diastole of the ventricles.
- When a heart rate is 75 bpm, a cardiac cycle lasts 0.8 seconds
The cardiac muscle fibers are contracting isometrically, but they aren’t yet shortening. All 4 valves are closed, and there is no change in blood volume of any heart chambers at this point.
Isovolumetric Contraction
A brief period in the cardiac cycle when all 4 valves are closed and the heart wall is relaxed
Isovolumetric Relaxation
Depolarization
Contractile fibers have stable resting membrane potential close to -90 mV. When the fibers are brought to threshold by an action potential, its voltage-gated fast Na channels open. This allows Na inflow. This produces rapid depolarization. Within seconds Na channels inactivate and Na inflow decrease
Repolarization:
This is the recovery of the resting membrane potential
- After a delay, additional voltage-gated K channels open. Outflow of K restores the negative resting membrane potential (-90mV). At the same time, the Ca channels in the sarcolemma and the sarcoplasmic reticulum are closing which also contributes to repolarization.
Self-excitable specialized cardiac muscle fibers that is the source of electrical activity
- They repeatedly generate action potentials that trigger heart contractions
- Act as a pacemaker, and form cardiac conduction system
Autorhythmic fibres
Intercalated Discs
Irregular transverse thickenings of the sarcolemma connecting ends of cardiac muscle fibers
Gap Junctions:
Allow muscle action potentials to conduct from one muscle fiber to its neighbour
Purkinje Fibers
Rapidly conduct action potential beginning at the apex of the heart upward to the remainder of the ventricular myocardium. Then the ventricles contract, pushing blood up to semilunar valves
Preload:
How much stretch is placed on the fibers of the heart wall before contraction occurs.
(Think of a balloon - if the balloon is blown up to its maximum, that would be a higher preload. If the balloon was only blown up a little, that would mean a lower pre-load.
Afterload
The pressure required for the ventricles to eject the blood
What events will follow when the pressure within the atria is higher than that of the ventricles?
Atrial Contraction (Atrial Systole)
- Depolarization of SA node causes atrial depolarization, marked by P wave
- Atria contracts, expert pressure on blood within, forces blood through the open AV valves into ventricles
- Contributes final 25ml of blood to volume in each ventricle (105ml). At the end of martial systole it relaxes, it then contains 130ml in each ventricle
What events will follow when the pressure within the ventricles is higher than that of the atria?
Ventricular Depolarization (Ventricular Systole)
- Pressure rises inside ventricles and pushes blood up against the atrioventricular valves, forcing them shut. For 0.5 sec, both atrioventricular and semilunar valves are closed Isovolumetric contraction
- Continued contraction on ventricles causes pressure inside chambers to rise sharply. Left ventricle surpasses the aortic pressure of 80mmHg, Right ventricle rises above the pressure of the pulmonary trunk. Then both semilunar valves open ventricular ejection
- Ejection of blood from heart now begins, pressure of Left ventricle rises to about 120mmHg, Right ventricle climbs to 25-30mmHg
- Represents the T wave
What needs to happen for the semilunar valves to open? What is the term used to describe this event
Ventricular Ejection
- This is caused when the pressure inside chambers rise sharply
- Pressure in left and right ventricle climb above pressure in pulmonary trunk causes valves to open
What needs to happen for the Atrioventricular Valves to open?
- When ventricles begin to relax, and the pressure falls quickly below the atrial pressure, the AV valves then open.
- Ventricular Filling begins (blood flowing into the atria rushes rapidly into the ventricles after the AV valves open)
Describe Epicardium
-External Layer
Composed of 2 layers
-Outermost is visceral of serous pericardium
Innermost composed of delicate fibroelastic tissue and adipose tissue
-Contains blood vessels and lymphatic that supply myocardium