Midterm Flashcards
(63 cards)
How long does sperm maturation take?
70-80 days
Describe the pathway of testosterone production from cholesterol
cholesterol –> pregnenolone –> DHEA
–> estradiol –> testosterone
OR
(DHEA) –> testosterone
(be able to recognize, true or false question)
What enzyme converts estradiol to testosterone?
aromatase
Cholesterol is converted to ____ which is converted to progesterone
pregnenolone
What 2 hormones are produced by fat cells?
estrogen
leptin
What BMI’s are associated with compromised fertility in women?
<20 kg/m
>30 kg/m
With obesity and waist circumference over 35 inches, there is a reduction in ____
sex hormone binding globulin (SHBG)
(normally binds excess hormone)
Contraceptive pills of the 1960’s had high doses of ____ and ____ with many side effects
estrogen & progesterone
Current oral contraceptive pills (OCP’s) have ____ doses of hormones and are mainly ____ based
lower
progesterone
Name 4 significant risks associated with OCPs
- breast cancer
- HPV/cervical cancer
- CVD
- DVT/PE
Name 7 contraindications to OCPs
- obesity
- > 35 years old
- smoking
- Hx of CVD
- HTN
- diabetes
- immobility
Vitamin ____ levels tend to be 33% lower with OCPs
B
Serum ____ levels tend to be 34-55% higher in patients on OCPs and will need ____ supplementation support
copper
zinc
What drug-induced nutrient depletions (DIND) are associated with OCPs?
- folic acid
- B2 (riboflavin)
- B6 (pyridoxine)
- B12 (cobalamin)
- vitamin C
- vitamin E
- magnesium
- selenium
- zinc
What is the maternal anabolic state?
- 1st 20 weeks = storage
- build mother’s capacity to deliver nutrients
What is the maternal catabolic state?
- 2nd 20 weeks
- nutrient & energy delivery takes place (90% of fetal growth)
Total body water increases by ____ during pregnancy
7-10 L
(2-2.5 gals)
Calorie needs are increased to about ____ cal/day during most of pregnancy
300
(*varies: 350 cal/day 2nd trimester, 450 cal/day 3rd trimester)
Calorie balance should be (positive/negative) throughout pregnancy
positive
What is the minimum amount of carbs per day to meet glucose requirements of the developing baby brain?
175 g/day
(50-65% of calories)
What is the minimum amount of protein per day during pregnancy?
75 g/day
(1.5 g/kg body weight)
What are the recommendations for vitamin D3 during pregnancy?
2000 IU
(most women need 4000-5000 IU in winter months)
Babies born in what months are at significantly higher risk of MS?
April or May
(than those born in Oct or Nov)
How are the following processes affected by pregnancy?
- calcium absorption from food
- calcium excretion from urine
- bone mineral turnover rate
all increase