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Pharma final written 2nd semester pq > Midterm 2(ecto endo parasites) > Flashcards

Midterm 2(ecto endo parasites) Flashcards

(134 cards)

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1
Q

Which agent has the longest duration of action n administered in therapeutic dosages?

  • Afoxolaner
  • Fluralaner
  • Sarolaner
  • Their duration is similar
A

Sarolaner

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2
Q

What is the mechanism of action of fipronil?

  • Acetylcoline receptor agonism
  • Acetylcholinesterase inhibition
  • GABA receptor agonism
  • GABA receptor antagonism
A

Gaba receptor antagonism

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3
Q

Fluralaner is effective against…

Flea

Both of them

Demodex spp

None of them

A

Both of them

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4
Q

Which is eliminated with the urine as well?

  • Fluralaner
  • Afoxalaner
  • Sarolaner
  • Lotilaner
A

afoxalaner

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5
Q

What is the mechanism of action of indoxacarb?

  • Na channel blocking
  • Glutamate mediated Cl channel opening
  • GABA receptor antagonsim
  • Acetylcholinesterase inhibtion
A

Na channel Blocking

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6
Q

Ectoparasiticide agents can be given

  • Both of them
  • Orally
  • Topically
  • None of them
A

Both

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7
Q

Which substance is an organophosphate from the followings:

  • None of them
  • Propoxur
  • Dinotefuran
  • Both of them
A

none

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8
Q

How can coumaphos be neutralized if it gets on the skin?

  • With baking soda
  • With tap water
  • With acetic acid
  • With all of them
A

with baking soda

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9
Q

Praziquantel can NOT be used againstthe following helminth:

  • Echinococcus granulosus
  • Heartworm
  • Both of them
  • None of them
A

Heartworm

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10
Q

Which agent is the safest for the environment from the followings:

  • Indoxacarb
  • Imidacloprid
  • Fipronil
  • Permethrin
A

indoxacarb

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11
Q

How can fipronil be used in companion animals?

  • Spot on
  • Pour on
  • Both
  • None
A

both

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12
Q

Imidacloprid can be given:

  • Collar
  • Ijnection
  • None
  • Both
A

collar

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13
Q

Izoxasolines are authorized for

  • Horse
  • Cat
  • Noth
  • None
A

cat

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14
Q

What is characteristic to the mechanism of action of permethrin?

  • GABA receptor agonism
  • Na channel opening
  • Acetlcholine receptor antagonism
  • Acetylcholinesterase inhibition
A

Na channel opening

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15
Q

Which can be the side effect of Amitraz?

  • Hypoglycaemia
  • Both
  • None
  • Paralytic ileus
A

paralytic ileus

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16
Q

How can Amitraz be given?

  • Collar
  • Washing solution
  • Both
  • None
A

Both

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17
Q

Permethrin is effective agianst this parasite:

  • Demodex
  • Tick
  • None
  • Both
A

none

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18
Q

Which agent has activity against fleas?

  • Fipronil
  • Piriprol
  • None
  • Both
A

piropril

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19
Q

Which agent has activity against fleas?

  • Nitenpyram
  • Afoxolaner
  • None
  • Both
A

afoxolaner

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20
Q

Wich side effect is characteristic to organophosphates?

  • Both
  • None
  • Difficult breathing bradycardia
  • Flaccid paralysys, ataxia
A

none

difficulty breathing bradycardia

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21
Q

Propoxur poisoning causes these symptoms:

  • Midriasis
  • Tremor, spams
  • Both
  • None
A

midriasis

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22
Q

What is characteristic to the mechanism of action of permethrin?

  • Gaba receptor agonims
  • Na channel opening
  • Acetylcholine receptor antagonism
  • Acetylcholinesterase inhibition
A

na channel opening

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23
Q

What is the mechanism of action of neonicotinoids?

  • Acetylcholine receptor agonism
  • Acetylcholinesterase inhibtion
  • Gaba receptor antagonism
  • Na channel blocking
A

acetylcholine receptor agonism

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24
Q

What is the characteristic to the spectrum of febantel?

  • Antitrematodal effect
  • Antinematodal effect
  • None
  • Both
A

antinematodal effect

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25
What is the characteristic to the spectrum of oxibendazole? - Anticestodal effect - Antinematoda effect - Both - None
antinematoda effect
26
How can albendazole be given? - Via injection - Both - Orally - None
orally
27
What is the characteristic to the mechanism of action of benzimidazoles? - Tegumentum damage - Decreased ATP production - None - Both
both
28
Which can be the side effect of Amitraz? - Tachypnoe - Bradycardia - None - Both
bradycardia
29
Amitraz is effective against this parasite: - Tick - Demodex - Both - None
both
30
Which agent is a prodrug from the followings - None - Triclabedazole - Fenbendazole - Both
none
31
What is the characteristic to the spectrum of oxfendazole - Anticestodal effect - Antinematodal effect - None - Both
both
32
Levamisole can be used against the following helminth - Ascaris suum - Fasciola hepática - Dipylidium caninum - All of them
ascaris suum
33
What is the characteristic to the spectrum of fenbendazole - Hookworms - Tapeworms - Both - None
both
34
Praziquantel can NOT be used against the following helminth - Dipylidium caninum - Fasciola hepática - None - Both
none
35
Repellent effect is important against - Mosquito - Tick - Both - None
both
36
What is the characteristic to the pharmacokinetics of praziquantel? - Not absorbed from the skin - Hydroxy metabolites form quickly - Moderate distribution due to high protein binding - None
hydroxy metabolites form quickly
37
Which of the following agent belongs to the imidazotiazoles - Levamisole - Praziquantel - Pyrantel - Fenbendazole
levamisole
38
Which of the following agent is an endectocid? - Permethrin - Toltrazuril - Levamisole - None
levamisole
39
Which substance is an organophosphate from the followings: - phoxim - Piriprol - none - Both of them
phoxim
40
What is the antidote for levamisole toxicosis - Epinephrine - Atropin - N-acetylcystein - There’s no antidote
atropin
41
Which agent has activity against fleas? - Ivermectin - Both - None - Indoxacarb
Both
42
Which can be the side effect of Amitraz? - Sedation - Emesis - Both - None
sedation
43
Praziquantel can be used against the helminth - Strongylus species - Dipylidium caninum - None - Both
Dipylidium caninum
44
What mechanism of action of organophosphates - Irreversible inhibition of acetylcolinesterase - Reversible inhibtion of acetylcholinesterase - Acetylcholine receptor agonims - Acetylcholine receptor antagonism
irreversible inhibition of acetylcolinesterase
45
How can levamisole be given? - IV - SC - Both - None
sc
46
Izoxasolines can cause these side effects in case of overdose: - Ataxia, muscle weakness, flaccid paralysis - Ataxia, tremor, spasm - Sedation, hypotermia - Emesis, bronchoconstriction, bradycardia
ataxia tremor spasm
47
Which is an IGR - Both of them - None - Novaluron - Methoprene
methoprene
48
Which is a chitin inhibitor - Lufenuron - Methoprene - None - Both
Lufenuron
49
Which can be an antidote of pyrethroid poisoning - Pralidoxime - Atipemazol - None - Atropin
Atropin
50
Which agent can be used to treat flea infection in dogs: - Pyrantel - Imidacloprid - Both - None
imidacloprid
51
What is the characteristic to the absorption of benzimidazoles from the GI tract? - Their absorption is excellent, bioavailability is nearly 100% - Their absorption is por - Absorption is moderate - They’re not used orally
absorption is moderate
52
What is the characteristic to the mechanism of action of benzimidazoles? - None - Agonism od the nicotinic acetylcholine receptor - Reversible inhibition of the acetylcholinesterase - Both
none
53
Which agent is effective against dermanyssus gallinae - Pyriproxyfen - Fluralaner - Flumehrin - Allof them
fluralaner
54
Which agent kills fleas most quickly? - Fipronil - Imidacloprid - Methoprene - Amitraz
imidacloprid
55
Which is true for organophosphates - LD50 ORAL \> LD50 DERMAL - LD50 ORAL \< LD50 DERMAL - LD50 ORAL - LD50 DERMAL -
All of them can be correct, it depends on the substance
56
Deltamethrin is effective against - Demodex spp - Fly - Both - None
both
57
Which species is sensitive to fipronil - Cat - Dog - None - Both
none
58
Sarolaner is effective against - Scabies mite - Tick - Both - None
both
59
Dinotefuran is effective against the following parasite - None - Scabies mite - Tick - Both
tick
60
What is the mechanism of action of neonicotinoids - Acetylcholine receptor agonism - Acetylcholinesterase inhibitin - Gaba receptor antagonism - Na channel blocking
acetylcholine receptor agonism
61
Which agent is a prodrug - Both - None - Febantel - Netobimin
both
62
Which agent is a prodrug - None - Both - Oxfendazole - Albendazole
none
63
What is the characteristic to the mechanism of action of benzimidazoles? - Damage of the endoplasmatic reticulum and mitochondrium - Cholinergic effect - Both - None
Damage of the endoplasmic reticulum and mitochondrium
64
Benzimidazoles have the shortest duration of action in this species - Horse - Cattle - Swine - Sheep
Sheep
65
Resistance to benzimidazoles occurs in - Canine taenia - Both - Equine strongylus - None
equine strongylus
66
Which agent has activity against fleas - Nitenpyram - Afoxolaner - None - Both
both
67
Which species is sensitive to amitraz - Sheep - Cat - Both - None
cat
68
What are the symptoms of permethrin poisoning - Hyperthermia - Tremor - Both - None
tremor
69
How are organophosphates eliminated - Mostly with bile - Mostly urine - Mostly sweat - Mostly with saliva and exhalation
mostly urine
70
Which drug can be used for the treatment of pyrethroid poisoning - Atipemazol - Diazepam - Both - None
none
71
What is the characteristic to the mechanism of action of amitraz - Monoamine oxidase inhibition - Alpha 2 receptor agonist - Both - None
both
72
Which is a systemic ectoparasiticide agent - Albendazole - Afoxolaner - Both - None
both
73
Fluralaner is effective against - Mosquito - Tick - Both - None
tick
74
What is the mechanism of action of propoxur - Reversible inhibition of acetylcholinesterase - irreversible inhibition of acetylcholinesterase - acetylcholine receptor agonist - acetylchline receptor antagonist
reversible inhibition of acetylcholinesterase
75
how does humidity affect the toxicity of diazinon - increases - decreases - doesn’t affect - depending on the level of humifity, can increase or decrease.
increases
76
What is the characteristic to the mechanism of action of macrocyclic lactones - cholinergic effect - calcium channel damage and cosequental spastic paralysis - teguentum damage - opening the glutamate-mediated chloride ion channels
opening the glutamate mediated chloride ion channels
77
cross-resistance is possible between levamisole and - tetrahydropyrimidines - benzimidazoles - pyrethroids - isoquinoline derivates.
tetrahydropyrimidines
78
Which agent can cause hyperpolarization in the parasite - moxidectin. - Imidacloprid - Both of them - None
none
79
Which is a juvenile hormone analogue from the follwoings - Pyriproxyfen - Piriprol - Pyrantel - Permethrin
pyriproxyfen
80
Macrocyclic lactone can have the following side effects - Muscle weakness, blindness, coma - Spastic paralysis, followedby coma - Emesis, diarrhea, fetal damage - Salivation, bronchoconstriction, bradycardia, urination
muscle weakness, blindness coma
81
Which of the following agent belongs to the imidazotiazoles - Levamisole - Praziquantel - Pyrantel - Fenbendazole
levamisole
82
How can amitraz be given - Chewing tablet - Injection - Both - None
none
83
What is the characteristic to the mechanism of action of amitraz - Alpha 2 receptor antagonism - Inhibition of octopamine reuptake from synaptic gap - None - Both
inhibition of octopamine reuptake from synaptic gap
84
Which is the most effective agent - Afoxolaner - Sarolaner - Fluralaner - Similar efficacy
fluralaner
85
Praziquantel can be used against - Ascaris suum - Anoplocephala perfoliate - Both - None
86
Praziquantel can be used against - Echinococcus granulosus - Syngamus trachea (red tracheal worm) - Both - None
Echinococcus granulosus
87
What is the spectrum of fenbendazole - Anticestodal effect - Antinematodal effect - Both - None
both
88
Which dog breed is sensitive to levamisole - Kuvasz - Chihuaha - Dobermann - West highland white terrier
Kuvasz
89
How can macrocyclic lactones be given - Topically - Via inhalation - Both - None
topically
90
This mechanism leads to the selective toxicity of ectoparasiticide - Slower metabolism in the parasite - Good distribution special barriers - Both - None
Both
91
Juvenile hormone analogues are effective against this arthropod - Scabies mite - Fly - Both - None
scabies mites
92
Repellent effect is important against this arthropod - Demodex - Fly - Both - None
demodex
93
Mechanism of action of permethrin - Gaba receptor agonis - Na channel opening - Acetylcholine receptor antagonism - Acetylcholinesterase inhibition
Na channel opening
94
Izoxasolines can be combined with - Pyrethroids - Macrocyclic lactones - Juvenile hormone analogues - All of them
macrocyclic lactones
95
Propoxur poisoning causes - Emesis, diarrhea - Both - Difficult breathing - None
emesis diarrhea
96
Organophosphates are effective against - Flea - Both - Lice - None
Both
97
How can benzimidazoles be given - Via injection - Orally - All of them - Topically
all of them
98
What is characteristic to the pharmacokinetics of levamisole - Quick absorption, distribution and elimination - Poor absorption and distribution, barely crossing the special barriers
poor absorption and distribution, barely crossing the special barriers
99
Which is an antidote of formamidine poisoning - Pralidoxime - Both - None - Epinephrine
none
100
Izoxasolines can be given - None - Collar - Injection - Both
none
101
Nitenpyram is available in this form for companion animals - Tablet - Injection
Tablet
102
Which is an etiotropic agent - Milbemycin oxime - Meloxicam - Medetomidine - Acepromazine
Milbemycin oxime
103
Which of the following is an endectocid - Flumethrin - Triclabendazole - Emodepszid
Flumethrin
104
Which species is sensitive to levamisole - Horse - Turkey - Chameleon - Sheep
horse
105
What is the characteristic to the mechanism of action of isoquinolones - Reversible inhibition of the acetylcholinesterase - Calcium metabolism famage and consequential spastic paralysis - Inhibtion of microtubules polymerization - Gaba receptor agonism
calcium metabolism damage and consequentia spastic paralysis
106
Levamisole toxicosis can cause - Sympatic signs - Parasympatic signs - Svere kidney damage - Flaccid paralysis
Parasympatic signs
107
Which dog breed is sensitive to ivermectin - Only sheperds - Only terriers - Dogs are not sensitive - Any breed with MDR-1 mutation
any breed with MDR 1 mutation
108
Izoxasolines can be given - tablet - none - spot on - Both
tablet
109
Which is true for amitraz - In case of poisoning, alpha 2 receptor related symptoms occur - Both - Increased catecholamine effect elevates… - None
both
110
Organophosphates are effective against - Tick - Scabies mites - Both - None
both
111
Fipronil is effective against - Demodex canis - None - Both - Ctenocephalides felis
ctenocephalides felis
112
Which agent has repellent effect - Fluralaner - Both - Flumethrin - None
flumethrin
113
Diazinon is metabolised to… in the body - Diazoxon - Coumaphos - Both - None
diazoxon
114
Which is an effective antidote of coumaphos poisoning - Pralidoxime - Epinephrine - Digoxin - Meloxicam
pralidoxme
115
What is characteristic to the pharmacokinetics of praziquantel - Elimination only in unchanged form - Quick and good absorption if given orally - Cumulation in fatty tissues due to lipofilic structure
quick and good absorption if given orally
116
Which agent has repellent effect - Metopren - Both - None - Deltamethrin
none
117
Which species is the most sensitive to organophosphates Sheep Cat Dog Cattle
118
Which substance is an organophosphate from the followings: - None of them - coumaphos - Dympilate - Both of them
both of them
119
Which is not an etiotropic agent - Doramectin - Dinotefuran - Dexamethasone - Diazinon
dexamethasone
120
How can finopril be used in companion animals - Tablet - Injection - None - Finopril can not be used in comapanion animals
fipronil can not used in companion animals
121
MDR-1 gene mutation is more frequent in this dog breed - German sheperd - Bobtail - The mutation doesn’t occur in these breeds - Its similar in both of them
german shepard
122
Which agent does not have adulticide effect - None - Methoprene - Lufenuron - Both
both
123
Izoxasolines are authorized for - Horse - Cats - Both - None
cats
124
Which macrocyclic lactone is effective against demodicosis - Selamectin - Amitrazsel - Both - None
selamectin
125
What is characteristic to the pharmacokinetics of macrocyclic lactones - They are hydrophilic substances, so they are eliminated quickly with the urine - Their absorption is only good if they are given in injections - They cannot cross the blood brain barrier - They can cumulate in fatty tissues
they can accumulate in fatty tissues
126
Macrocyclic lactone toxicosis has higher risk in - Some dog breeds - Some cattle breeds - None - Both
some dog breeds
127
What is characteristic to the mechanism of action of benzimidazoles - Inhibition of microtubules polymerization - Inhibtion of the gaba mediated chloride ion channels - Both - None
inhibition of microtubles polymerization
128
What are the symptoms of permethrin poisoning - Myosis - Both - Spams - None
none
129
What is characteristic to the mechanism of action of flumethrin - Glutamate mediated cl channel opening - Hot foot effect - Both - None
hot foot effect
130
Repellent effect is important against - Roundworms - Scabies mites - None - Both
scabies mites
131
How can diazinon be neutralized if it gets on the skin - With soap and water - With concentrated alcohol - Both - None
132
Flumethrin is effective against - Phlebotomus spp - Both - Varroa destructor - None
both
133
How can benzimidazoles be given - In premix - In intraruminal bolus - Both - None
both
134
Which statement is true? Usage of ectoparasiticide agents is inevitable because - Ectoparasites can be vectors, intermediate hosts for other parasites - Ectoparasites can make anials stressful - Both - None
both

Pharma final written 2nd semester pq (2 decks)

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