Midterm Flashcards

(59 cards)

1
Q

Endogenous acetylcholine effects which site(s)?

A

muscarinic, ganglionic, somatic motor

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2
Q

Muscarine effects which sites?

A

muscarinic

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3
Q

Pilocarpine effects which sites?

A

muscarinic (main), ganglionic (mild)

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4
Q

Arecoline effects which sites?

A

muscarinic, ganglionic

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5
Q

Physostigmine effects which sites?

A

muscarinic, ganglionic, somatic motor

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6
Q

Nicotine effects which sites?

A

ganglionic, somatic motor

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7
Q

Lobeline effects which sites?

A

ganglionic somatic motor

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8
Q

Endogenous norepineohrine effects which sites?

A

adrenergic

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9
Q

Ephedrine effects which sites?

A

adrenergic

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10
Q

Cocaine effects which sites?

A

adrenergic

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11
Q

Endogenous ach mechanism of action?

A

direct agonist

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12
Q

muscarine mechanism of action?

A

direct agonist

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13
Q

arecoline mechanism of action?

A

direct agonist

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14
Q

physostigmine mechanism of action?

A

inhibits the enzyme that breaks down ach

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15
Q

nicotine mechanism of action

A

direct agonist

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16
Q

lobeline mechanism of action

A

direct agonist

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17
Q

endogenous norepinephrine mechanism of action

A

direct agonist

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18
Q

ephedrine mechanism of action

A

direct agonist & also increases the release of norepinephrine from nerve terminus

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19
Q

cocaine mechanism of action

A

norepinephrine re-uptake inhibitor

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20
Q

pilocarpine mechanism of action

A

direct agonist

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21
Q

Scopolamine, atropine, ipatropium effects which sites?

A

Muscarinic

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22
Q

d-tubocurarine effects which sites?

A

ganglionic, somatic motor

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23
Q

botulinum toxin effects which sites?

A

muscarinic, ganglionic somatic

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24
Q

reserpine effects which sites?

25
nicotine (high doses) effects which sites?
ganglionic
26
nicotine (high doses) mechanism of action
Direct antagonist causing persistent depolarization that causes receptor to shut down
27
reserpine mechanism of action
damages vesicles that contain catecholamines and tryptamines in nerve terminus
28
botulinum toxin mechanism of action
decreases relealse of ach from nerve terminus
29
d-tubocurarine mechanism of action
direct antagonist at nicotonic receptors
30
scopolamine, atropine, ipatropium mechanism of action
direct antagonist
31
increased heart rate, dialted pupils, decreased GI motility, increased sweating
endogenous sympathetic response
32
increased heart rate, dilated pupils, decreased GI motility
Ephedrine, cocaine
33
increased heart rate, dilated pupils, increased mouth secretions, decreased GI motility, decreased sweating
Atropine, scopolamine
34
normal, heart rate, pupils, moth secretion and GI motility
Endogenous parasympathetic response
35
decreased heart rate, constricted pupils. increased mouth secretions, increased GI motility, increased sweating
muscarine, pilocarpinem arecoline, physostigmine
36
endogneous seratonin mechanism of action
direct agonist
37
endogenous DMT mechanism of action
direct agonist
38
DMT-Psychotria viridis mechanism of action
direct tryptamine agonist
39
LSD mechanism of action
direct agonist, re-uptake inhibitor, indolemine
40
Lysergol from Calviceps purpurea mechanism of action
direct tryptamine agonist, indolemine
41
Psilocybin & psilocin
direct tryptamine agonist, indolemine
42
Mescaline from Lophophora & Echinopsis
Direct tryptamine agonist, phenethylamine
43
MDMA (ectasy)
Direct agonist, phenethylamine
44
MDA
Direct agonist, phenethylamine
45
Ibogaine from Tabernanthe iboga
Direct tryaptamine agonist & kappa opioid receptor agonist
46
Hyperforin from Hypericum perforatum
re-uptake inhibitor
47
harmine, harmalie from Banisteriopsos caapi
Re-uptake inhibitor (MAO)
48
Gabtril
GABA re-uptake inhibitor
49
Valerian
GABA direct agonist
50
Kava
GABA agonist
51
Thujone
GABA antagoist
52
Picrotoxin
GABA antagonist
53
Illex paraguariensis
Contains chllorogenic acids
54
Forskalin
increases adenylate cyclase enzyme
55
caffeine
blocks adenosine receptor
56
cathinone
increase # of NT from nerve terminus
57
Methamphetamine and other derivatives
Increase release of NT from nerve terminus
58
bromocriptine & pergolide
direct agonist
59
salvinorin A
kappa opioid receptor agonist