Midterm (DSM) Flashcards
(182 cards)
Bipolar - Etiology
Diathesis-Stress Model
Heritability is high: 60-85%
- 10-25% chance of having bipolar if one parent has it
- Shared genetic origin with schizophrenia
MRI studies
- Prefrontal cortex smaller and functions less well
- Reduced grey matter
- Demyelination in white matter
Hallucinations
a false sensory perception that occurs in the absence of an external sensory stimulus
involuntary, appear real
auditory or visual hallucinations are most common
a person must be awake and fully alert to experience a hallucination
-hypnaogic or hynopompic (waht we see or hear when we’re falling asleep) are normal and are not hallucinations
Autism Spectrum Disorder - Specifiers
With or without accompanying inteliectual impairment
With or without accompanying language impairment
-without language was aspergers
Associated with a icnown medicai or genetic condition or environmental factor
-Used to be Retts and CDD
Associated with another neurodevelopmental, mental, or behavioral disorder
With catatonia
Autism Spectrum Disorder - Differential Diagnosis - Stereotypic movement disorder
Motor stereotypies are among the diagnostic characteristics
of autism spectrum disorder, so an additional diagnosis of stereotypic movement
disorder is not given when such repetitive behaviors are better explained by the presence
of autism spectrum disorder. However, when stereotypies cause self-injury and become a
focus of treatment, both diagnoses may be appropriate.
ADHD - Differential Diagnosis - Other Neurodevelopmental Disorders
The increased motoric activity that may occur in
ADHD must be distinguished from the repetitive motor behavior that characterizes stereotypic
movement disorder and some cases of autism spectrum disorder. In stereotypic
movement disorder, the motoric behavior is generally fixed and repetitive (e.g., body rocking,
self-biting), whereas the fidgetiness and restlessness in ADHD are typically generalized
and not characterized by repetitive stereotypic movements. In Tourette’s disorder,
frequent multiple tics can be mistaken for the generalized fidgetiness of ADHD. Prolonged
observation may be needed to differentiate fidgetiness from bouts of multiple tics.
Persistent (Chronic) Motor or Vocal Tic Disorder Criteria
A. Single or multiple motor or vocal tics have been present during the illness, but not both
motor and vocal.
B. The tics may wax and wane in frequency but have persisted for more than 1 year since
first tic onset.
C. Onset is before age 18 years.
D. The disturbance is not attributable to the physiological effects of a substance (e.g., cocaine)
or another medical condition (e.g., Huntington’s disease, postviral encephalitis).
E. Criteria have never been met for Tourette’s disorder.
Specify
- with motor tics only
- with vocal tics only
Delusions
A strongly held false belief that remains unchanged, despite evidence to the contrary
Several types
- Persecutory
- Referential
- Grandiose
- Erotomanic
- Jealous
- Nihilistic
- Somatic
- Thought control
- Passivity
Bizarre (non-possible) or nonbizarre (improbable but possible)
Major Depressive Epidsode - Criteria
A. Five (or more) of the following symptoms have been present during the same 2-week period and represent a change from previous functioning; at least one of the symptoms is either (1) depressed mood or (2) loss of interest or pleasure.
Note: Do not include symptoms that are clearly attributable to another medical condition.
- Depressed mood most of the day, nearly every day, as indicated by either subjective
report (e.g., feels sad, empty, or hopeless) or observation made by others (e.g.,
appears tearful). (Note: In children and adolescents, can be irritable mood.) - Markedly diminished interest or pleasure in all, or almost all, activities most of the
day, nearly every day (as indicated by either subjective account or observation). - Significant weight loss when not dieting or weight gain (e.g., a change of more than
5% of body weight in a month), or decrease or increase in appetite nearly every
day. (Note: In children, consider failure to make expected weight gain.) - Insomnia or hypersomnia nearly every day.
- Psychomotor agitation or retardation nearly every day (observable by others; not
merely subjective feelings of restlessness or being slowed down). - Fatigue or loss of energy nearly every day.
- Feelings of worthlessness or excessive or inappropriate guilt (which may be delusional)
nearly every day (not merely self-reproach or guilt about being sick). - Diminished ability to think or concentrate, or indecisiveness, nearly every day (either
by subjective account or as observed by others). - Recurrent thoughts of death (not just fear of dying), recurrent suicidal ideation without
a specific plan, or a suicide attempt or a specific plan for committing suicide.
B. The symptoms cause clinically significant distress or impairment in social, occupational,
or other important areas of functioning.
C. The episode is not attributable to the physiological effects of a substance or another
medical condition.
Note: Criteria A-C constitute a major depressive episode. Major depressive episodes are
common in bipolar I disorder but are not required for the diagnosis of bipolar I disorder.
Note: Responses to a significant loss (e.g., bereavement, financial ruin, losses from a
natural disaster, a serious medical illness or disability) may include the feelings of intense
sadness, rumination about the loss, insomnia, poor appetite, and weight loss noted in Criterion
A, which may resemble a depressive episode. Although such symptoms may be understandable
or considered appropriate to the loss, the presence of a major depressive
episode in addition to the normal response to a significant loss should also be carefully
considered. This decision inevitably requires the exercise of clinical judgment based on
the individual’s history and the cultural norms for the expression of distress in the context
of loss.
Schizophrenia - Differential Diagnosis - Schizophreniform Disorder and Brief Psychotic Disorder
These disorders are of shorter
duration than schizophrenia as specified in Criterion C, which requires 6 months of symptoms.
In schizophreniform disorder, the disturbance is present less than 6 months, and in
brief psychotic disorder, symptoms are present at least 1 day but less than 1 month.
Intellectual Disability - Differential Diagnosis - Communication Disorders and Specific Learning Disorder
These neurodevelopmental disorders are specific to the communication and learning domains and do not show deficits in intellectual and adaptive behavior. They may co-occur with intellectual disability. Both diagnoses are made if full criteria are met for intellectual disability and a communication disorder or specific learning disorder.
Syndrome
this term is applied to a constellation of symptoms that occur together or co-vary over time
Tic Disorders - Prevalence
3 per 1000 in school-age children
Meta-analysis of 35 studies
.77% tourette’s
2.99% “Transient Tic Disorder”
.05% among adults
2:1 to 4:1 male to female ratio
Tends to be lower in African American and Hispanic populations
ADHD - Course
Continues through adolescence and often adulthood
Typically hyperactivity decreases (brain maturation)
Higher risk for ODD, CD, and Substance Use Disorder
Functional Outcomes:
Power school/work performance Lower academic/work atainment Unemployment Social rejection Accidents and injuries Fmaily conflict
ADHD - Differential Diagnosis - Neurocognitive Disorders
Early major neurocognitive disorder (dementia) and/or
mild neurocognitive disorder are not known to be associated with ADHD but may present
with similar clinical features. These conditions are distinguished from ADHD by their late
onset.
Tic Disorders - Differential Diagnosis - Abnormal Movements that may accompany other medical conditiosn and stereotypic movement disorder
Motor stereotypies are defined as involuntary rhythmic, repetitive,
predictable movements that appear purposeful but serve no obvious adaptive function or
purpose and stop with distraction. Examples include repetitive hand waving/rotating,
arm flapping, and finger wiggling. Motor stereotypies can be differentiated from tics based
on the former’s earlier age at onset (younger than 3 years), prolonged duration (seconds to
minutes), constant repetitive fixed form and location, exacerbation when engrossed in activities,
lack of a premonitory urge, and cessation with distraction (e.g., name called or
touched). Chorea represents rapid, random, continual, abrupt, irregular, unpredictable,
nonstereotyped actions that are usually bilateral and affect all parts of the body (i.e., face,
trunk, and limbs). The timing, direction, and distribution of movements vary from moment
to moment, and movements usually worsen during attempted voluntary action. Dystonia
is the simultaneous sustained contracture of both agonist and antagonist muscles,
resulting in a distorted posture or movement of parts of the body. Dystonie postures are often
triggered by attempts at voluntary movements and are not seen during sleep.
Stererotypic Movement Disorder - Differential Diagnosis - Other neurological and medical conditions
The diagnosis of stereotypic movements
requires the exclusion of habits, mannerisms, paroxysmal dyskinesias, and benign hereditary
chorea. A neurological history and examination are required to assess features
suggestive of other disorders, such as myoclonus, dystonia, tics, and chorea. Involuntary
movements associated with a neurological condition may be distinguished by their signs
and symptoms. For example, repetitive, stereotypic movements in tardive dyskinesia can
be distinguished by a history of chronic neuroleptic use and characteristic oral or facial
dyskinesia or irregular trunk or limb movements. These types of movements do not result
in self-injury. A diagnosis of stereotypic movement disorder is not appropriate for repetitive
skin picking or scratching associated with amphetamine intoxication or abuse (e.g.,
patients are diagnosed with substance/medication-induced obsessive-compulsive and related
disorder) and repetitive choreoathetoid movements associated with other neurological
disorders.
Specific Learning Disorder - Differential Diagnosis - Learning Difficulties Due to Neurological or Sensory Disorders
Specific learning disorder
is distinguished from learning difficulties due to neurological or sensory disorders
(e.g., pediatric stroke, traumatic brain injury, hearing impairment, vision impairment), because
in these cases there are abnormal findings on neurological examination.
What makes bipolar hard to diagnose?
People come in for the depression, not the manias, may not see mania as a problem
High rates of comorbidity
Shared psychotic features
Difficulty disentangling timelines from substance use
So many variations in how it presents in the room/how people experience the disorder
ADHD - Differential Diagnosis - Specific Learning Disorder
Children with specific learning disorder may appear inattentive
because of frustration, lack of interest, or limited ability. However, inattention in
individuals with a specific learning disorder who do not have ADHD is not impairing outside
of academic work.
Schizophrenia - Differential Diagnosis - Postraumatic Stress Disorder
Posttraumatic stress disorder may include flashbacks that
have a hallucinatory quality, and hypervigilance may reach paranoid proportions. But a traumatic
event and characteristic symptom features relating to reliving or reacting to the event
are required to make the diagnosis.
Schizoaffective Disorder - Prevalence and Course
Lifetime Prevalence = .3%
More common among females, especially depressive type
Typical age of onset – early adulthood
- Bioplar type more common amongst young adults
- Depressive type more common among older adults
Prognosis slightly better than schizophrenia, but worse than mood disorders
-often associated with impaired functioning, although not part of criterion
Intellectual Disability - Differential Diagnosis - Autism Spectrum Disorder
ID is common among individuals with autism spectrum disorder. Assessment of intellectual ability may be complicated by social- communication and behavior deficits inherent to autism spectrum disorder, which may interfere with understanding and complying with test procedures. Appropriate assessment of intellectual functioning in autism spectrum disorder is essential, with reassessment across the developmental period, because IQ scores in autism spectrum disorder may be unstable, particularly in early childhood.
Bipolar - Prevalence
1.8% - 4.4% of US population (lifeactime) across BDI, BDII, and BDNOS
12-month prevalence rate
BDI = 0.6%
BDII = 0.8%
Nearly equal in men and women
Rapid cycling, mixed states, and depressive episodes more often in women
Schizophreniform Disorder - Criteria
A. Two (or more) of the following, each present for a significant portion of time during a
1-month period (or less if successfully treated). At least one of these must be (1), (2),
or (3):
1. Delusions.
2. Hallucinations.
3. Disorganized speech (e.g., frequent derailment or incoherence).
4. Grossly disorganized or catatonic behavior.
5. Negative symptoms (i.e., diminished emotional expression or avolition).
B. An episode of the disorder lasts at least 1 month but less than 6 months. When the
diagnosis must be made without waiting for recovery, it should be qualified as “provisional.”
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C. Schizoaffective disorder and depressive or bipolar disorder with psychotic features have
been ruled out because either 1 ) no major depressive or manic episodes have occurred
concurrently with the active-phase symptoms, or 2) if mood episodes have occurred during
active-phase symptoms, they have been present for a minority of the total duration
of the active and residual periods of the illness.
D. The disturbance is not attributable to the physiological effects of a substance (e.g., a
drug of abuse, a medication) or another medical condition.
Note: impairment in social and occupational functioning is not required