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II. Posterior Segment Disease > Midterm I > Flashcards

Flashcards in Midterm I Deck (131):

Where are the two groups of blood vessels in the retina located?

1. superficial nerve fiber layer
2. inner nuclear layer


Where does the outer plexiform layer and outward receive its oxygen and nutrients from?

choroid and choriocapillaris


What layers usually separate in a retinal detachment?

RPE and sensory retina


What are the five methods to view the retina?

1. OCT
2. BIO
3. peripheral funduscopy
4. 3 mirror funduscopy
5. Optos optimap


What is the junction of the inner and outer photoreceptor segments called? 1. What does it show up as on the OCT? 2

1. photoreceptor integrity layer
2. thin red line above RPE


What does the RPE look like on the OCT?

deep red layer


What landmarks define the peripheral retina? 1. Posterior pole? 2. Midperiphery? 3

1. area between vortex veins and ora sorrata
2. bound by arcades
3. arcades to vortex veins


What is used to push the peripheral retina into view?

scleral indentation/depression


Does the optos optomap get to ora?



What is the Optos Optomap not adequate at displaying?

retinal breaks


What are the ways to view the vitreous?

1. direct ophthalmoscope (add plus from retina)
2. fundus lens
3. BIO (shadows on retina)
4. slit lamp


What is the "skin" around the vitreous which is tightly attached to the internal limiting membrane of the retina? 1. Where is it absent? 2

1. hyaloid
2. optic nerve head


What are the stronger hyaloid attachments of the vitreous from weakest to strongest?

1. macula
2. blood vessels
3. around ONH (tightest posterior)
4. vitreous base (at ora and a little into retina)


What is the clumping of solids during the deterioration of the hyaloronic acid that holds the vitreous together called?

condensation or floaters


What are the disorders that can lead to vitreal change in consistency and transparency earlier in life than expected?

1. systemic vascular disease
2. myopia over about 4-5 D
3. connective tissue disorders
4. inherited disorders
5. trauma


What are the systemic vascular diseases that can lead to early vitreal deterioration?

1. diabetes
2. sickle cell anemia
3. leukemia


What are the connective tissue disorders that can lead to early vitreal deterioration?

1. Marfan's
2. Pseudoxanthoma elacticum (PXE)
3. Ehlers Danlos


What is the number one reason for retinal break/detachment in children?

Wagner-Jensen-Stickler's (aka Stickler's)


What are the major changes in the vitreous over time in order from most to least important structurally?

1. loss of hyaluronic acid the maintains gel-like consistency
2. hyaloid atrophies
3. vitreous collagen breaks down
4. liquid content increases


What is the term for the hyaloid tugging on the internal limiting membrane?

vitreal-retinal traction


What is the separation of the posterior hyaloid and the internal limiting membrane called?

posterior vitreous detachment (PVD)


What is usually the last portion of the hyaloid that separates from the internal limiting membrane? 1. What is this called? 2. What does this lead to? 3

1. hyaloid around optic nerve head
2. complete PVD
3. Weiss ring or Vogts ring


What is it called when the hyaloid falls forward toward the crystalline lens following detachment?

PVD with collapse or syneresis


What are flashes of light associated with a PVD called?



About how long does it take for a complete PVD to occur after the first detachment occurs?

3-6 months


What do the tails of the vitreous base predispose the retina to?

retinal breaks in the periphery


What is caused by breaks in the internal limiting membrane and the proliferation of cells on its surface?

epiretinal membrane (ERM)


What are the other names for an epiretinal membrane (ERM)?

1. preretinal membrane
2. macular pucker
3. surface-wrinkling retinopathy
4. cellophane retinopathy


What cells form the epiretinal membrane?

glial, muller or RPE cells


What are the ways to "catch" a epiretinal membrane?

1. patient complaints of distorted vision following PVD
2. shinning or glimmering when looking at the retina


What are the causes of ILM breaks?

1. vitreo-retinal traction
2. vascular disease (hypoxic atrophy)
3. retinal breaks


What are the treatments for an epiretinal membrane?

1. remove vitreous (vitrectomy)
2. epiretinal membrane peeled off


What can a epiretinal membrane lead to?

1. metamorphopsia
2. macular edema
3. decrease in vision


What is a hemorrhage resulting from vitreo-retinal traction called? 1. What layers is this between? 2. Where in the retina does this typically occur? 3

1. preretinal hemorrhage
2. between internal limiting membrane and nerve fiber layer
3. peripheral retina


What are the two possible reasons for a preretinal heme?

1. vitreo-retinal traction
2. new blood vessel growth from systemic vascular disease


What should be done for a patient with a systemic vascular disorder and a preretinal heme?

refer to retinal ophthalmologist (NEVER monitor)


What is the common shape of a preretinal heme?

D-shaped or keel-shaped because of gravity pooling blood in that area of the "dome"


What is it called when the preretinal heme makes its way through the ILM, hyaloid and into the vitreous? 1. What might the doctor see upon fundus examination? 2

1. vitreal heme
2. red blood or nothing at all (no retina seen)


What should be done for a patient that has a vitreal heme? 1. Why? 2

1. refer (NEVER monitor)
2. large amount associated with breaks, possible significant traction, and can be retroneovscularization


What do patients often see when they have a vitreal heme?

red blood seen as sudden small shower of floaters


What is the shape of a vitreal heme? 1. What color does it turn with time? 2

1. no normal shape and changes often
2. yellow then black


What is the problem that can occur from a vitreo-retinal traction that is the result of recurrent inflammatory reactions? 1. What does the patient see? 2

1. transient macular edema
2. distorted vision


What are the two forms of retinal breaks? 1. What is the location in the retina that the break is often located? 2

1. retinal hole and retinal tear
2. peripheral


What color is a retinal break? 1. Why? 2

1. red
2. looking at choriocapillaris through full-thickness opening


What color is the choroid? 1. Why? 2

1. purple-blue
2. melanin within


Is a retinal hole likely to lead to a retinal detachment? 1. Is a retinal tear? 2

1. no (2-3%)
2. yes (30-50%)


What is the escape of pigment into the anterior portion of the vitreous due to the liquefied vitreous getting into the RPE and breaking the bonds between the RPE cells called? 1. What originally causes this to occur? 2

1. tobacco dust or Shafer's sign
2. retinal break


What is tobacco dust a probable sign of?

impending or active retinal detachment


What is the number one mechanism of retinal detachment?

liquefied vitreous getting into the RPE and breaking the bonds between the RPE cells


What are the two things that can surround a retinal hole?

1. cuff of whiteish edema
2. RPE hyperplasia


What does a cuff of whiteish edema around a retinal hole indicate? 1. What should be done for a patient with this? 2

1. vitreoretinal traction that creates intraretinal edema and mild sensory retinal detachment
2. refer if edema is one disc diameter or more


What does RPE hyperplasia surrounding a retinal hole indicate?

lesion at least 3 months old


What is degenerative thinning of the peripheral retina called? 1. What can this lead to? 2

1. lattice degeneration
2. atrophic hole (can also be from atrophy)


What is the type of retinal hole that is from vitreo-retinal traction and retinal thinning?



What is a portion of the retinal tissue that has detached and is now floating in the vitreous called?



If there is pigment adjacent to a operculated hole, how old is the hole?

at least 3 months


Which retinal hole type is generally worse at first: atrophic or operculated?



What are the major things to consider in managing a retinal hole?

1. is the patient symptomatic?
2. atrophic or operculated?
3. peripheral or central (central worse)
4. superior or inferior (superior worse)
5. is there a cuff of edema, how large?
6. Does the hole have a black pigment around it?


What are the differences in identifying retinal holes vs. retinal hemes?

1. holes round, hemes usually not
2. holes have edema ring, hemes do not


What should be done for a patient with a retinal tear?



What color is a retinal tear?. How often does it occur following a PVD? 2

1. red with edematous white surrounding
2. 10-15%


What is the progression of a retinal tear allowing liquified vitreous to go through retina and enter the space between the RPE and sensory retina, causing separation called?

rhegmatogenous retinal detachment


What do the brighter portions of tissue that is on the edge of a retinal detachment?

elevated tissue that vitreous is pushing up


What procedure greatly increases the risk of a retinal detachment?

cataract surgery


What is the time period that a retinal detachment occurs following an acute retinal tear?

within 6 weeks


How long after a PVD occurs is it highly unlikely that a retinal detachment will occur because of the PVD?

6 months


What is the main symptom of a retinal detachment?

increase in flashes and floaters


What is the procedure for follow up appointments after a PVD occurs with symptoms of flashes and floaters?

1 month, 1 month, 6 months


What should be told and documented to the patient following a PVD?

if they see a shower of flashes or floaters increasing in intensity they should come in immediately


What is required during the exam of a patient that has a PVD and has symptoms of flashes and floaters?

must get to ora in all 4 quadrants


What are the symptoms of a rhegmatogenous retinal detachment?

1. flashes
2. floaters
3. curtains
4. most are asymptomatic


What group of people do traumatic detachments mostly occur in? 1. Myopic detachments? 2

1. young people
2. aged 25-45


What is more likely to cause a retinal detachment: a new break or an old break?

new break


How often should phakic retinal detachment patients be dilated for an exam?

every 6 months


How does a rhegmetogenous retinal detachment appear on examination?

1. undulating with elevated ridges of retina that moves when eye moves
2. opaque with time


Why does a rhegmetogenous retinal detachment look white?

1. edema
2. tissue is dead/scarring


What is the pigment hyperplasia line at the posterior border that occurs after a retinal detachment is stationary for about 3 months?

demarcation line or high water mark


What occurs in a long-standing retinal detachment to the retinal tissue after a long period of time?

tissue becomes necrotic and see yellow intraretinal exudates


What happens to the IOP with a retinal detachment (and why)?

1. IOP elevated (Schwartz syndrome)
2. IOP reduced (break gives route for uveoscleral outflow)


What must be done by the optometrist as far as management of a retinal detachment?

get same day consultation


What are the questions that will be asked when referring a patient for a retinal detachment?

1. how big is it
2. where is it
3. is the macula on or off


What is the largest deciding factor of visual impact for a retinal detachment?

whether it's macula-on or macula-off


What are the procedures for a retinal detachment that is not too large?

1. laser treatment (scarring to reattach retina to RPE)
2. pneumatic retinopexy


What is the injection of an expanding bubble of gas into the vitreous to push the retina against the RPE and recreate adhesion called?

pneumatic retinopexy


What are the procedures for a retinal detachment that is large?

scleral buckling


What is the most common procedure for repair of a rhegmatogenous retinal detachment?

scleral buckle


What is a scleral buckle made out of? 1. What is the buckle sutured into? 2

1. silicone
2. to sclera (explant) or within sclera (implant)


What are the procedures that often accompany scleral buckling?

1. diathermy
2. cryotherapy
3. laser photocoagulation


What is sometimes done during the scleral buckling procedure to prevent increases in IOP?

drain subretinal fluid


What are the scleral buckling post-operative complications?

1. glaucoma
2. infection and extrusion
3. choroidal edema
4. cystoid macular edema
5. epiretinal membrane (macular pucker)
6. diplopia
7. changes in refractive error


When does cystoid macular edema usually occur following scleral buckling surgery?

4-6 weeks


What is an extremely bad epiretinal membrane that is extremely thick and causes extreme distortion called?

proliferative vitreoretinopathy (PVR)


What can lead to diplopia following scleral buckling surgery?

1. proliferative vitreoretinopathy (PVR)
2.cystoid macular edema
3. EOM rubbing


What are the problems in refractive error that can occur following scleral buckling surgery?

1. more myopic
2. irregular astigmatism


What percentage of scleral buckling procedures result in anatomical reattachment?



What percentage of patients with macula-on retinal detachments lose less than 2 Sellen acuity lines after scleral buckling?



What percentage of patients with macula-off retinal detachment are worse than 20/50 after scleral buckling?



What procedures are often done in conjunction with pneumatic retinopexy?



What is the procedure in which silicone oil is put into the back of the eye to push the retina against the RPE for re-adhesion and needs to be removed eventually?

silicone oil tamponade


When is silicone tamponade used for a retinal detachment?

1. patient doesn't want pneumatic retinopexy
2. intractable case where detachemtn cannot be stopped


When is a vitrectomy used to treat a retinal detachment?

1. PVR occurs
2. still areas of vitreo-retinal traction


What is essential in determining the stage of a macular hole?



What are the main features of a stage 1 macular hole?

1. macular cyst
2. may leave dark red lamellar hole


During stage 1 of a macular hole with a macular cyst present, what is at the base of the fovea and is a yellow spot?



What does a lamellar hole due to visual acuity?

around 20/40-20/60


What are the main features of a stage 2 macular hole?

1. small hole (


What are the main features of a stage 3 macular hole?

1. full thickness hole (1/2 to 1/3 DD)
2. Very red
3. surrounded by cuff of edema often
4. yellow deposits in base of hole


What impact does a stage 3 macular hole have on visual acuity?

20/200 or worse


What are the main features of a stage 4 macular hole?

1. full thickness hole like in stage 3
2. all other features of stage three are same
3. no hyaloid attachment is present


What are the ways to tell the difference between stage 3 and stage 4 macular holes?

1. OCT
2. look for grey spot or clump directly over fovea (pseudo-operculum)


What is the thickened portion of the hyaloid that is detached from the fovea and can sometimes be seen following a stage 4 macular hole?



What are the treatments for a macular hole?

1. vitrectomy with pneumatic retinopexy
2. plasma enzyme (Ocriplasmin)


Following a vitrectomy with pneumatic retinopexy what is required of the patient?

need to lay face down most of the time for 10-14 days


What does the injection of the plasma enzyme (Ocriplasmin) due for a patient with a macular hole? 1. What procedure is it sometimes done with? 2

1. dissolves attachments between hyaloid and internal limiting membrane
2. vitrectomy


What are the yellow-white spheres of calcium soaps that are in the vitreous? 1. What is their impact on vision? 2

1. asteroid hyalosis or Benson's bodies
2. little effect on visual acuity and patient rarely notices them


What diseases are asteroid hyalosis associated with?

1. diabetes
2. systemic hypertension
3. systemic atherosclerotic vascular disease


What are accumulations of flat crystals of cholesterol in the vitreous called? 1. When are they often seen? 2

1. synchisis scintillans
2. blind or severely damaged eyes


What is the failure of regression of the structures of the primary vitreous, resulting in a dense vitreous called? 1. Who is it usually seen in? 2

1. Persistent Hyperplastic primary vitreous (PHPV)
2. full-term infants


What other ocular anomalies is PHPV associated with?

1. microphthalmos
2. cataract
3. prominent ciliary processes


What is the appearance of PHPV?

1. white pupil (leukocoria)
2. may see hyaloid canal


What are the differentials when a white pupil (leukocoria) is seen in an infant or child?

1. cataract
2. retinoblastoma
3. retinopathy of prematurity


What are the four essential aspects of isolated retinal lesions that lead to a differential diagnosis?

1. location
2. color
3. border (well-defined and shape)
4. size and elevation


What are dark grey/brown/black areas on the retina that are due to enlargement of RPE cells?

congenital RPE hypertrophy (CHRPE)


What is the typical location of CHRPE? 1. Description of border? 2. Elevation? 3

1. peripheral
2. fairly well-defined
3. flat


What can form within CHRPE due to a blockage of blood supply to the RPE and can lead to scarring?

chorioretinal atrophy (lacunae)


What are the two variants of CHRPE (and what are the sizes of each)?

1. multifocal (usually


What is the ocular effect of CHRPE?

benign but can create visual field defect (scotoma)


What disease has an association with CHRPE? 1. What presentation of CHRPE do they have? 2

1. familial adenomatous polyposis (FAP)
2. irregular multiple unifocal CHRPE lesions (usually 4 or more)


What is the disease that presents with the development of polyps in the large intestines around puberty and often results in colon cancer?

familial adenomatous polyposis (FAP)


What must CHRPE be differentiated from?

malignant melanoma


What can CHRPE lead to (but is very rare)?

RPE adenocarcinoma