MIDTERM MAJOR BLOOD GROUP Flashcards
(127 cards)
1
Q
It is a unique blood group system because its antigens are not intrinsic to RBCs
A
Lewis blood group system
2
Q
ISBT number of Lewis blood group system
A
007
3
Q
Specific location of Lewis gene
A
Chromosome 19p13.3
4
Q
Secretor gene location
A
19q13.3
5
Q
2 major antigens of Lewis system
A
Lea and Leb
6
Q
Lewis phenotype of an ABH nonsecretor
A
Le(a+b–)
7
Q
Lewis phenotype of an ABH secretor
A
Le(a–b+)
8
Q
Lewis RBC phenotype that are either secretors or nonsecretors
A
Le(a–b–)
9
Q
Lewis phenotype that rare in whites and africans but are more common in asians
A
Le(a+b+)
10
Q
Lewis antigens are found on
A
Lymphocytes, platelets, pancreas, stomach, intestine, skeletal muscle, renal cortex, and adrenal glands (Main: Intestinal tract epithelial cells)
11
Q
Lewis Antigens are found on the secretions as
A
glycoprotein (Leb)
12
Q
Lewis antigens are found on the plasma as
A
glycolipids (Lea)
13
Q
True or False: Lewis antigens are resistant to treatment with enzymes
A
True
14
Q
Lewis antibodies are what class of antibodies
A
IgM
15
Q
Lewis phenotype of pregnant women
A
Le(a–b–)
16
Q
Lewis antibodies (can bind/cannot bind) complements
A
CAN BIND
17
Q
most commonly encountered antibodies of Lewis
A
Lea
18
Q
Anti-lea is often detected at what temperature
A
room temp (but sometimes react @37C in IAT)
19
Q
2 categories of Anti-Leb
A
- Anti- LebH
- Anti - LebL
20
Q
reacts best when both the Leb and the H antigens are present on the RBC, such as group O and A2 cells
A
Anti-LebH
21
Q
recognizes any Leb antigen regardless of the ABO type
A
Anti-LebL
22
Q
Give the RBC phenotype
Genes: Le, Se, A/B/H
A
A, B, H, Le(a – b+)
23
Q
Give the RBC phenotype
Genes: lele, Se, A/B/H
A
A, B, H, Le(a – b –)
24
Q
Give the RBC phenotype
Genes: Le, sese, A/B/H
A
A, B, H, Le(a+b –)
25
Give the RBC phenotype
Genes: lele, sese, A/B/H
A, B, H, Le(a – b –)
26
Give the RBC phenotype
Genes: Le, sese, hh, A/B
Oh, Le(a+b –)
27
Give the RBC phenotype
Genes: Le, Se, hh, A/B
A*, B*, Le(a – b+)
28
primary source of Lewis glycolipid in plasma
gastrointestinal tract (intestinal tract epithelial cells)
29
What is the true lewis phenotype
Le(a–b+)
30
A heterogenous antibody which occurs mainly in Le(a-b-)
Anti-Leab
31
present on all Le(a+b–) and Le(a–b+) RBCs and on 90% of cord RBCs
Leab (previously known as Lex)
32
ISBT number of P Blood Group System
003
33
What are the P Blood group Antigens
P1, Pk
34
The P blood group was introduced by
Landsteiner and levine
35
Who described anti-P1Pk
Levine and colleagues
36
Anti-PP1Pk was formerly known as
Anti-Tja
37
Who described Pk antigen
Matson and coworkers
38
Two common phenotype in P blood group system
P1 and P2
39
Antigens present in P1 phenotype
P1, P, Pk*
40
Antigens present in P2 phenotype
P, Pk*
41
Antigens present in p phenotype
None
42
Antigens present in P1k phenotype
P1, Pk
43
Antigens present in P2k Phenotype
pk
44
at what age can the P1 antigen be fully expressed
7 years old
45
What class of antibodies are Anti-P1
IgM
46
Anti-P1 can be neutralized with
soluble P1 substance
47
True or False: HDFN is commonly associated with anti-P1
False
48
The P1PK gene is located at what chromosome
chromosome 22q11.2
49
The P gene is located at what chromosome
chromosome 3q26.1
50
Where is P1 antigen and antibody first discovered
individual infected with Echinococcus granulosus
51
Sources of P1 antigen
RBCs, plasma, droppings of pigeons and
turtledoves, eggwhite of turtledoves
52
Sources of P1 Antibody
Clonorchis sinensis, Opisthorchis viverrine,
Ascaris suum, Lumbricoides terrestris
53
associated with increased incidence of spontaneous abortions in early pregnancy
Anti-PP1 Pk
54
Associated with PCH (Paroxysmal Cold Hemoglobinuria) [tertiary syphilis; transient, acute condition secondary to viral infection, young children]
Autoanti-P
55
Autoanti-P is also known as
Donath Landsteiner Antibody
56
Originally called anti-Tja, anti-PP1Pk was first described in the serum of
Mrs. Jay
57
Components of anti-PP1Pk have been shown to be what class of antibodies
IgM and IgG
58
has the potential to cause severe HTRs and HDFN
Anti-PP1Pk
59
ISBT number of I blood group system
027
60
The I blood group system was discovered by
Wiener and coworkers
61
The I in antigen I stands for
Individuality
62
True or false: I and i are not antithetical antigens
True
63
In I blood group system, infant RBCs are rich in what antigen
i antigen
64
In I blood group system, adult RBCs are rich in what antigen
I antigen
65
Some people appear not to change their i status after birth, these individuals express what phenotype
adult i
66
Adult I Phenotype strength of reactivity with Anti-I, Anti-i, and Anti-It respectively
Strong, Weak, Weak
67
Cord Phenotype strength of reactivity with Anti-I, Anti-i, and Anti-It respectively
Weak, Strong, Strong
68
Adult i Phenotype strength of reactivity with Anti-I, Anti-i, and Anti-It respectively
Weak Strong Weakest
69
microogranism with I specificity
M. pneumoniae
70
True or false: Anti-I is not associated with HDFN
True
71
Sources of I and i antigens
leukocytes and platelets
(also found in in saliva, human milk, amniotic
fluid, urine, and ovarian cyst fluid)
72
The It antigen and Antibody was reported by
Curtain and coworkers
73
the T in It refers to
Transition
74
Disease association of anti-It
warm autoimmune hemolytic anemia, Hodgkin’s disease
75
MNS system ISBT number
002
76
Location of M and N antigens
glycophorin A
77
M antigen amino acid residues at postions 1 and 5
1= serine
2= glycine
78
N antigen amino acid residues at postions 1 and 5
1= leucine
5 = glutamic acid
79
S and s antigens are located on
glycophorin B
80
S and s amino acid at position 29
S= methionine
s= threonine
81
What enzymes can destroy S and s antigens
Ficin, papain, bromelin, pronase, and chymotrypsin
82
Anti-M (do not bind/ bind) complement
do not bind
83
Anti-M are pH dependent reacting best at what pH
6.5
84
Anti-M lectin
Iberis amara
85
Anti-N (do not bind/bind) to complement
Do not bind
86
Lectins of Anti-N
Vicia graminea
Bauhinia variegata
Bauhinia purpurea
87
What substance can alter M and N antigen
Formaldehyde
88
Anti-S and Anti-s (can/cannot) bind complement
Can bind complement
89
The genes GYPA and GYPB, which code for GPA and GPB, respectively, are located on
chromosome 4q28-q31
90
partial/complete deletion of GPB
U(universal)-Phenotype
91
gene deletion of GPA
En (a-) Phenotype (Envelope)
92
rare silent gene
Mk Phenotype (Null)
93
Kell blood group ISBT number
006
94
first blood group system discovered after the introduction of antiglobulin testing
Kell blood group system
95
Anti-K was identified in the serum of
Mrs. kelleher
96
Most immunogenic second to D
KELL BLOOD GROUP SYSTEM
97
KEL gene is located at what chromosome
chromosome 7q34
98
K antigen can be detected on fetal RBCs as early as
10 weeks
99
The k antigen can been detected at
7 weeks
100
Kell antigens
Kpa and Kpb
101
what organism was shown to
have a somatic K-like antigen that reacted with the infant’s antibody, and was was thought to be the stimulus.
E. coli O125:B15
102
X-linked, occurs when Kx antigen is not expressed; Associated with Chronic Granulomatous Disease (CGD)
McLeod Phenotype
103
Duffy system ISBT number
008
104
The duffy blood group system was named after
Mr. Duffy
105
Null phenotype in duffy system
Fy(a–b–)
106
common genotype in blacks, especially in
Africa; the gene is exceedingly rare in whites
FyFy
107
Fy(a–b–) RBCs can resist what organism/s
Plasmodium knowlesi
Plasmodium vivax
108
what are the duffy antigens
Fya, Fyb
109
Anti-Fya and Anti-Fyb (can/cannot) bind complement
can bind
110
Duffy gene genetic abnormality
chromosome 1q23.2
111
antibody made by Duffy Null phenotype
Anti-Fy3
112
Kidd blood group system ISBT number
009
113
abundant in Polynesians; also been found in
Filipinos, Indonesians, Chinese, and Japanese
Jk null
114
Rh Null antibodies of kidd
anti-jk3
115
Organism with Jkb-like specificity include
Enterococcus faecium, Micrococcus and Proteus mirabilis
116
Lutheran blood group system ISBT number
005
117
The Jk locus is found on what chromosome
18q12.3
118
The lutheran antibody was named after
lutteran
119
Who described Anti-Lub
Cutbush and Chanarin
120
RBCs will have a ____________ if they are from a white donor
Double dose of Fya
121
RBCs will have a _______ Fya if they are from a black donor
single dose
122
inherited weak form of Fyb that reacts with some examples of anti-Fyb
Fyx
123
inseparable anti-FyaFyb
Fy3
124
Antigens in Kidd blood group system
jka and jkb
125
Estimated number of Lub sites per RBC on Lu(a–b+)
1,640 to 4,070
126
Estimated number of Lub sites per RBC on Lu(a+b+)
850 to 1,820
127
