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Flashcards in Midterms Deck (52):
1

Anemia characterized by increased destruction of RBCs and decreased erythropoiesis

Hemolytic anemia

2

Causes of intrinsic hemolytic anemia

Hemoglobinopathies
Membranopathies
Enzymopathies

3

Examples of hemoglobinopathies associated with intrinsic HA

Sickle cell anemia
Thalassemia

4

Condition in bone marrow due to high production of RBCs

Erythroid hyperplasia

5

Proteins involved in hereditary spherocytosis

Band 3
Ankyrin
Spectrin

6

Proteins involved in hereditary elliptocytosis

Protein 4.1
Spectrin

7

Protein for anion transport

Band 3

8

Connects band 3 and ankyrin

Protein 4.1

9

Protein of primary cytoskeleton

Spectrin

10

Proteins for flexibility of cell membrane

Actin
Tropomyosin
Protein 4.1

11

Cause of intravascular HA

Synthetic heart valve

12

Enzymopathies in HA result to

Splenomegaly
Heinz bodies
Bite cells

13

G6PD is part of what pathway

HMP (hexose monophosphate pathway)

14

Products of G6P + NADP rxn

NADPH + phosphogluconate

15

Utilizes NADPH for removal of stress oxidant (ROS)

Glutathione reductase

16

Normal relationship of NADPH and ROS

High NADPH, low ROS

17

Abnormal relationship of NADPH and ROS

Low NADPH, high ROS

18

Heinz bodies are stained by

Supravital stain

19

High ROS = ? Hb denaturation

Increased

20

Enzyme for ATP production

Pyruvate kinase

21

Poikilocyte resulting from the sequestration of spleen

Bite cell

22

Substance that inhibits pyrimidine-5-nucleotidase

Lead/Pb

23

RBC inclusion related to pyrimidine-5-nucleotidase

Basophilic stippling

24

Condition of extrinsic hemolytic anemia involved in prehepatic jaundice

IMHA

25

Transcribe IMHA

Immune mediated hemolytic anemia

26

Test ideal for autoimmune HA

Coomb's test or direct agglutination test

27

Small clots cause bursting of RBCs within a vessel (name the condition)

Microangiopathic hemolytic anemia (MAHA)

28

Causes of MAHA

DIC, TTP

29

Poikilocyte found in MAHA

Schistocyte

30

Individuals with this condition is rsistant to malaria

Duffy null (no Duffy Ag)

31

Duffy Ag is the receptor to what species

P. knowlesi, P. vivax

32

Fetal Rh incompatibility causes what disease

HDN

33

Treatment to sensitize the mother's RBCs

RhoGAM

34

Hereditary spherocytosis is most common in what race

Northern Europeans

35

Spherocytes have _ surface/volume ratio

Low

36

T/F: Spherocytes cannot stretch

T (true)

37

Most impt. test/parameter for spherocytosis

EOFT

38

RBCs in hypertonic solution

Shrink/crenate

39

RBCs in hypotonic solution

Swell/burst

40

Coomb's test result for spherocytosis

Negative

41

MCV for spherocytosis

Normal or decreased

42

The only condition with hyperchromia (high MCHC)

Hereditary spherocytosis

43

Brain tissues bacome yellowish

Kernicterous

44

Concentration of bilirubin to cause kernicterous condition

20mg/dL

45

Findings in UTZ(ultrasound) test in spherocytosis

Cholelithiasis (gall stones)

46

Gallstones are formed from ____ + _____

Ca + B1

47

Test useful to detect Band 3

Eosin-5-maleimide

48

Differrential test for hereditary spherocytosis and elliptocytosis

Eosin-5-maleimide

49

Condition in which the sinusoids of the spleen may be blocked

Hereditary elliptocytosis

50

Heat sensitive variant of hereditary elliptocytosis

Hereditary pyropoikilocytosis

51

MCHC in her. elliptocytosis

Normal

52

Hereditary ovalocytosis is also known as

Southeast Asian Ovalocytosis