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Hematology 2 > Midterms > Flashcards

Midterms Flashcards

(52 cards)

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1
Q

Anemia characterized by increased destruction of RBCs and decreased erythropoiesis

A

Hemolytic anemia

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2
Q

Causes of intrinsic hemolytic anemia

A

Hemoglobinopathies
Membranopathies
Enzymopathies

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3
Q

Examples of hemoglobinopathies associated with intrinsic HA

A

Sickle cell anemia

Thalassemia

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4
Q

Condition in bone marrow due to high production of RBCs

A

Erythroid hyperplasia

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5
Q

Proteins involved in hereditary spherocytosis

A

Band 3
Ankyrin
Spectrin

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6
Q

Proteins involved in hereditary elliptocytosis

A

Protein 4.1

Spectrin

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7
Q

Protein for anion transport

A

Band 3

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8
Q

Connects band 3 and ankyrin

A

Protein 4.1

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9
Q

Protein of primary cytoskeleton

A

Spectrin

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10
Q

Proteins for flexibility of cell membrane

A

Actin
Tropomyosin
Protein 4.1

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11
Q

Cause of intravascular HA

A

Synthetic heart valve

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12
Q

Enzymopathies in HA result to

A

Splenomegaly
Heinz bodies
Bite cells

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13
Q

G6PD is part of what pathway

A

HMP (hexose monophosphate pathway)

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14
Q

Products of G6P + NADP rxn

A

NADPH + phosphogluconate

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15
Q

Utilizes NADPH for removal of stress oxidant (ROS)

A

Glutathione reductase

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16
Q

Normal relationship of NADPH and ROS

A

High NADPH, low ROS

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17
Q

Abnormal relationship of NADPH and ROS

A

Low NADPH, high ROS

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18
Q

Heinz bodies are stained by

A

Supravital stain

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19
Q

High ROS = ? Hb denaturation

A

Increased

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20
Q

Enzyme for ATP production

A

Pyruvate kinase

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21
Q

Poikilocyte resulting from the sequestration of spleen

22
Q

Substance that inhibits pyrimidine-5-nucleotidase

23
Q

RBC inclusion related to pyrimidine-5-nucleotidase

Study These Flashcards
A

Basophilic stippling

24
Q

Condition of extrinsic hemolytic anemia involved in prehepatic jaundice

25
Transcribe IMHA
Immune mediated hemolytic anemia
26
Test ideal for autoimmune HA
Coomb's test or direct agglutination test
27
Small clots cause bursting of RBCs within a vessel (name the condition)
Microangiopathic hemolytic anemia (MAHA)
28
Causes of MAHA
DIC, TTP
29
Poikilocyte found in MAHA
Schistocyte
30
Individuals with this condition is rsistant to malaria
Duffy null (no Duffy Ag)
31
Duffy Ag is the receptor to what species
P. knowlesi, P. vivax
32
Fetal Rh incompatibility causes what disease
HDN
33
Treatment to sensitize the mother's RBCs
RhoGAM
34
Hereditary spherocytosis is most common in what race
Northern Europeans
35
Spherocytes have _ surface/volume ratio
Low
36
T/F: Spherocytes cannot stretch
T (true)
37
Most impt. test/parameter for spherocytosis
EOFT
38
RBCs in hypertonic solution
Shrink/crenate
39
RBCs in hypotonic solution
Swell/burst
40
Coomb's test result for spherocytosis
Negative
41
MCV for spherocytosis
Normal or decreased
42
The only condition with hyperchromia (high MCHC)
Hereditary spherocytosis
43
Brain tissues bacome yellowish
Kernicterous
44
Concentration of bilirubin to cause kernicterous condition
20mg/dL
45
Findings in UTZ(ultrasound) test in spherocytosis
Cholelithiasis (gall stones)
46
Gallstones are formed from ____ + _____
Ca + B1
47
Test useful to detect Band 3
Eosin-5-maleimide
48
Differrential test for hereditary spherocytosis and elliptocytosis
Eosin-5-maleimide
49
Condition in which the sinusoids of the spleen may be blocked
Hereditary elliptocytosis
50
Heat sensitive variant of hereditary elliptocytosis
Hereditary pyropoikilocytosis
51
MCHC in her. elliptocytosis
Normal
52
Hereditary ovalocytosis is also known as
Southeast Asian Ovalocytosis

Hematology 2 (2 decks)

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