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Flashcards in miRNA Deck (13):
1

miR-17-92

Represses RUNX1 which regulates colony stimulating factor receptor during monocytopoieses

2

miR-223

Promote monocyte and neutrophil differentiation

Represses myeloid ELF-like factor 2 to modulate neutrophil

3

miRNA-155

represses SHIP1 and CSFR to modulate myeloid cell differentiation

Represses expression of DC-SIGN

4

miR-34 and miR-21

Represses WNT1 and JAG1 to promote DC differentiation

5

How are miRNA involved in Cancer

Disregulation of miRNA is a hallmark of cancer

Upregulatuon of miRNA may act as oncogenes
Downregulated miRNA may be tumor suppressors

As if not more important than mutation to proteins in tumor development

6

miR-15a and mIR-16 are what and involved in which disease

Tumor suppressors that regulate bcl-2

Deleted in Chronic Lymphocytic Leukaemia

7

miR-29b does what and involved in what firsease

Tumor suppressor which represses specific DNA methyltransferases leading to global DNA hypomethylation and re-expressions of pro-apoptotic genes

8

What is miR 17-92

Can act as oncogene when overexpressed

Involved in Acute lymphoblastic leukaemia

Involved in Chronic myeloid leukaemia

9

miR-H2-3p

Herpesvirus miRNA from LAT pre-miRNA
Responsible for promoting latency

10

miRNA-K5

Targets BCALF1 (pro-apoptotic bcl2 protein) mRNA and targets for degradation inhibiting expression

11

mIR-let-7 in cancer

Loss of miR-let-7 enhances lung tumor formation

miR-let-7 is tumor suppressor

Synthetic let-7 shown effective in mouse models against lung tumor

12

miR-182 and cancer relation

Oncogenes
Overexpressed in melanoma

Us of miRNA sponge to reduce metastatic spread

13

miR-122 involvement in cancer

Abundant in liver and shown to stimulate HCV replication

Stabilises HCV genome by binding to 5'utr of genome unlike most which bind 3'UTR

Miravisen is miRNA sponge currently in phase 2 clinical trials