Misc Flashcards

Question

STI Genital ulcer cause

Answer 1

HSV, TP, Hducreyi (Chancroid), K granulomatis (Donavanosis), CT LGV

Answer 2

HIV aciclovir, TP Benzathine pen, Hducreyi Azith, Kgranu Azith, CT LGV Azith or Doxy - treatment of GC/CT has wiped out Hd & Kg

Answer 3

HIV and Syphilis should both be tested

Answer 4

400,000 (physical or psychological)

Answer 5

Depends on human-snake interaction (agriculture, building projects, travel, sleeping on ground, intentional handling, nocturnal hunting, mating season), weather, and children

Answer 6

Viper, adder, moccasins, rattlesnakes > short thick body, distinctive dorsal pattern, long fully erectable fangs which penetrate deep into tissues > shock, coagulopathy etc

Answer 7

Cobra, krait, mambas, all Oceanian/Aus, and sea snakes > long thin body and tail, uniformly coloured, fast, short permanently erect front fangs > descending flaccid paralysis, bilateral ptosis -> bulbar (+coagulopathy etc)

Answer 8

Complex - 100 protein/polypeptide toxins including phospholipases, metalloproteases, serine proteases, three-finger toxins (neuro- cyto-toxins) which clip over acetylcholine receptor > paralysis

Answer 9

Cytotoxicity (swelling, bruising, necrosis)l Haemo (coagulopathy), Neuro (descending flaccid paralysis), Cardio (arrhythmia, myocardial damage, leak, shock, orthostatic hypotension), Myo (rhabdo, hyperkalaemia), Nephro (AKI)

Answer 10

Clean dry glass vessel, tip once, positive (no clotting), negative (clotting)

Answer 11

Education, Protect feet, legs and hands, use light and prodding stick, sleep off the ground

Answer 12

Remove from danger, reassure, immobilise, remove any potential tourniquets, pressure-pad-immobilisation, transport rapidly in recovery position and admit for 24h

Answer 13

compress veins and lymphatics in immediate vicinity of bite

Answer 14

Refined IgG from hyperimmune horse/sheep plasma, scare and expensive to produce, only neutralises venom used in manufacture - cover medically-most-important snakes in geographical region

Answer 15

Shock, Systemic envenoming - incoagulable blood, neurotoxicity (ptosis), black urine, rapidly progressive local swelling (bites over digits)

Answer 16

Check species covered, infuse IV 10-60min, same dose for adults & children, prophylactic adrenaline SC may reduce reactions

Answer 17

IM adrenaline, early pyrogenic and/or anaphylactic reactions, late serum sickness

Answer 18

Tetanus, drain abscess & remove necrotic tissue, early rehabilitation. No evidence for other Rx including fasciotomy

Answer 19

Wear boots, repellents, search clothing & footwear/backpack, sleeping environment etc, sleep under insecticide impregnated bed net

Answer 20

>3250 fatalities, in Mexico, Sth America, Africa, Middle East, India, esp children, prevention is excluding from home and awareness, UV light useful

Answer 21

Ion channel stimulate/block cation Na K Ca channels > parasympathetic (cholinergic) and sympathetic (adrenergic)

Answer 22

Severe local pain, Systemic 'autonomic' storm from massive release of acetylcholine and catecholamines -> shock, arrhythmias, erratic eye movements, muscle spasms

Answer 23

Lignocaine infiltration, antivenom in some countries, and/or prazosin/vasodilators in ICU

Answer 24

Very few bites, common in Americas, mediterranean, South Africa, Australia

Answer 25

Brown recluse spiders - local pain, swelling, followed by classic red-white-blue sign, generalised rash, malaise, eventually eschar, necrotic slough, systemic sx 4-10%

Answer 26

Black/brown cosmopolitan spiders & funnel well - local immediate pain, sweating, systemic rapidly evolving headache, NV, priapism, muscle spasms,

Answer 27

History, mast cell tryptase, venom-specific IgE (skin or RAST), treat with adrenaline

Answer 28

Salty V vulnificus, Brackish A hydrophila

Answer 29

Remove from water to prevent drowning, immerse hot water 45C, box JF wash/shave tentacles with sea water, topical lignocaine, antivenom for seawasp and scorpion fish

Answer 30

Obey warning, don't swim alone in tropical seas, protective clothing, stings may hypersensitise with anaphylaxis on reexposure

Answer 31

Beware of handing fish, avoid touching coral, anemones, sea snakes etc, beware wading barefoot

Answer 32

Scombroid 1-120min, Puffer 10-180min, Shellfish 30-180min, Ciguatera 1-12h

Answer 33

1-12h, GI sx plus paraesthesias (esp hot-cold reversed sensation), rash, bradycardia, hypotension, can be confirmed by toxin detection in fish remnant (but not in patients) treat supportive +/- mannitol (controversial), amitriptyline

Answer 34

1-120min immediate perioral tingling, progressing to anaphylactic response, treat with histamine inhibitors +/- adrenaline

Answer 35

Don't rely on cooking - seafood toxins are heat/acid stable, avoid large fish (>10kg), eat only fresh fish and never eat puffer fish, avoid shellfish in red algae, don't swallow seafood that makes your lips tingle

Answer 36

5bil lack access to surgical care, 18 mil deaths could be avoided, 33mil face catastrophic expense after surgical care, 30% of Global Health Burden require surgery

Answer 37

Multidisciplinary field concerning the improved and equitable access to surgical care across international healthcare systems with focus on LMICs

Answer 38

Laparotomy, C-section, Open fracture management and wound debridement, D&C, closed fracture reduction

Answer 39

1 superficial 2A sup partial (red, painful, weeping), 2B deep partial (red, painful, dry), 3 full thickness (black/white, no feeling)

Answer 40

1% BSA is size of child's hand

Answer 41

Fluid (Modified Parkland), Pain (affects catabolism), Nutrition, Infection control, Tetanus vax

Answer 42

Early referral and advice, transport

Answer 43

Disproportionately affects populations living in poverty; and causes important morbidity and mortality – including stigma and discrimination - in such populations, justifying a global response

Answer 44

Primarily affects populations living in tropical and sub-tropical areas

Answer 45

MDA (praziquantel), sanitation, snail control

Answer 46

MDA (ivermectin), (vector control) - does not kill adult worm, need to treat for long time, and barrier to ivermectin use in loa loa endemic regions -> cerebral inflammation

Answer 47

MDA (ivermectin, albendazole), vector control - does not kill adult worm, need to treat for long time. Transmission targets - W bancrofti regions antigen prevalence by ICT rapid test <1% in children aged 6-7y. B malayi regions seroprevalence by BrugiaRapid <2% in children aged 6-7y

Answer 48

MDA (azithromycin), water, sanitation, education "SAFE" = Surgery, Antibiotics, clean Faces, Environment

Answer 49

MDA (azithromycin) - issue is latent infection is common, and serological test needed (VDRL/RPR)

Answer 50

MDA (albendazole)

Answer 51

Safe water, health education

Answer 52

Case finding and treatment (vector control). Challenge accessing to remote rural communities in areas of conflict

Answer 53

Case finding and treatment

Answer 54

Case finding and treatment

Answer 55

Sanitation, meat inspection, vaccination of pigs

Answer 56

Abattoir control, treatment of dogs, education

Answer 57

Treatment of sheep, health education

Answer 58

Vector control, blood screening

Answer 59

Case finding and treatment

Answer 60

Vaccination of dogs, health education

Answer 61

Vector control

Answer 62

Case finding and treatment

Answer 63

?MDA (ivermectin)

Answer 64

?Case finding, education - not yet established

Answer 65

?Case finding and treatment - not established

Answer 66

Reduction to zero of the incidence of a disease in a defined geographical area. Continued interventions required to prevent re-introduction

Answer 67

Permanent reduction to zero of the worldwide incidence of infection caused by a specific agent. Intervention measures no longer needed

Answer 68

Intervention effective, Surveillance (good diagnostic), No animal reservoir

Answer 69

Recognised as public health importance, technically feasible intervention, political commitment, advocacy plan

Answer 70

Lead to underreporting, lack of ongoing surveillance may lead to resurgence

Answer 71

New animal reservoir, or reduced surveillance once country certified as having met targets = resurgence. Attempts to meet the target may lead to under-reporting

Answer 72

a characteristic that is objectively measured and evaluated as an indicator of normal biological processes, pathological processes, or pharmacological response to a therapeutic intervention

Answer 73

WHO estimated in 2017 that 10.5% of medicines in LMIC are SF (substandard or falsified)

Answer 74

Degraded - leave factory in good quality but degrade due to improper storage (frozen/heated/light exposure etc), substandard - fail to meet quality standards or their specifications or both - result from factory error

Answer 75

Medical products that deliberately/fraudulently misrepresent their identity, composition or source

Answer 76

Medicine Quality Scientific Literature surveyor, early warning systems, 'Globe' monitoring system,

Answer 77

Plague vaccine 1902 contaminated with tetanus, Cutter incident 1955 Salk inactivated polio vaccine - failure of formaldehyde treatment resulting in live polio - many infections and deaths

Answer 78

Minilab thin layer chromatography, Rama spectroscopy 'see through bottles', Paper analytical devices 12 lines colorimetry

Answer 79

Used instead of propylene glycol -> renal toxins, consider if unexplained children with AKI

Answer 80

Functional regulatory authorities and monitoring, greater international political will, timely data sharing, targeted research

Answer 81

Always consider SF if you encounter AE, therapeutic or diagnostic failure, surprisingly inexpensive medical products, typos and packaging defects, report to NMRA and WHOrapidalert. Medicine falsification is world's 3rd oldest profession - not going to go away, key to minimising occurrence and impact, screening devices hold hope, multidisciplinary approach needed with increased research

Answer 82

Increased risk of common and health-care associated infection, association with 3.6 times higher TB risk

Answer 83

Handwashing, RCOG, antisepsis, antibiotics, midwives, universal healthcare, oxytocin, training, contraception, MgSO4, abortion laws, living standards, safer anaesthesia

Answer 84

Every day in 2020, almost 800 women died from preventable causes related to pregnancy and childbirth, 95% in LMIC, reflects inequalities in access to quality health services, humanitarian, conflict and post-conflict hinder progress in reducing burden,

Answer 85

HIC 1 in 5300, LMIC 1 in 49. For every woman who dies, another 20-30 suffer considerable morbidity

Answer 86

Severe bleeding (PPH), infections (usually after childbirth), high blood pressure during pregnancy, delivery complications, unsafe abortion

Answer 87

As a consequence of a disorder specific to pregnancy: haemorrhage, preeclampsia, genital tract sepsis

Answer 88

As a consequence of previous existing disease or diseases that developed during pregnancy and which were not due to direct obstetric causes but aggravated by pregnancy: eg cardiac disease, other infections (sepsis)

Answer 89

Coincidental: incidental/accidental deaths not due to pregnancy or aggravated by pregnancy eg MVA, late: deaths >42d but less than 1y after end of pregnancy

Answer 90

Most maternal deaths are preventable. Maternal health services are vulnerable to external factors such as conflict and humanitarian crises. Family planning is the most cost-effective intervention to reduce maternal mortality as part of an essential package for maternal health. WHO recommends a minimum of eight antenatal visits during pregnancy

Answer 91

Handheld notes are recommended by the WHO to improve quality of antenatal care. 90% of anaemia in pregnancy is due to nutritional deficiency. Tocolysis should be given in preterm labour as long as no infection or abruption is present, to allow time for steroids. Preterm birth is the single leading cause of perinatal mortality

Answer 92

There is evidence to show that clearly stating what the emergency is improves the outcome. Verbal consent may be taken for emergency Caesarean section. Delivery of the baby by perimortem Caesarean section (resuscitative hysterotomy) is part of resuscitating the woman, and the baby does not need to be alive. Maternal morbidity and mortality is higher in women who have poor access to antenatal care

Answer 93

Eclamptic seizures usually resolve initially prior to MgSO4 administration, but can be prolonged in severe disease. Causes of seizures in pregnancy include TB, malaria and eclampsia. It is essential to restrict intravenous fluids and monitor fluid balance with pre-eclampsia and eclampsia as women can develop pulmonary oedema due to capillary leakage. If a woman has an eclamptic fit she can have another pregnancy with prenatal counselling, consideration of aspirin, and monitoring. Pre-eclampsia generally develops a few weeks later in a subsequent pregnancy

Answer 94

Women with blood loss do not have tachycardia and hypovolaemia until very late. Risk factors for uterine rupture include previous Caesarean section, grandmultiparity and twin pregnancy. Signs of placental abruption may include a tender uterus and fetal distress. Haemorrhage is more common after a long labour

Answer 95

Most maternal deaths are preventable. Strategies to avoid unintended pregnancies (contraception, safe abortion), healthcare access to prevent or manage common pregnancy complications, UK mortality rate is lower, black women have 4x risk of dying in childbirth, and socially deprived (poor) 2x risk

Answer 96

Health system failures (poor quality care, insufficient numbers or training of healthcare staff, lack of essential resources/medical supplies, poor accountability), Social determinants (income, nutrition, education, race/ethnicity), Harmful gender norms (structural and individual), External factors (instability of health systems in conflict, climate, humanitarian crises)

Answer 97

1 Delay in decision to seek care (family/community level perceptions, education and awareness) 2 Delay in reaching appropriate care (accessibility: distance, time to travel, transportation cost/availability, distribution and location of health facilities) 3 Delay in receiving adequate care (quality of care: facilities, supplies, equipment, staff training, adequate & timely referral systems)

Answer 98

1 Address inequities in access to and quality of sexual, reproductive, maternal and newborn healthcare, 2 Ensure universal health coverage for comprehensive sexual, reproductive, maternal and newborn healthcare 3 Address all causes of maternal mortality, reproductive and maternal morbidities and related disabilities 4 Strengthen health systems to respond to the needs and priorities of women and girls 5 Ensure accountability in order to improve quality of care and equity

Answer 99

Family planning and preventing/managing unplanned pregnancy, Skilled assistance for delivery and management of complications including pre-eclampsia, sepsis, hypertensive disorders in pregnancy. Comprehensive antenatal care (including syphilis, tetanus vax and IPTp (intermittent preventive treatment) malaria. Iron and folic acid supplementation, antibiotics for PPROM and management of eclampsia with MgSO4

Answer 100

MultiD care to ensure best pregnancy outcomes, risk identification for preexisting conditions and those that develop during pregnancy, prevention and management of complications, prevent and manage concurrent diseases

Answer 101

Counsel on healthy eating & keeping physically active, daily oral iron and folic acid, and if appropriate calcium can reduce PET, Vitamin A in high deficiency states

Answer 102

Hb and urine culture, ask about intimate partner violence, routinely screen for gestational diabetes, tobacco/substance misuse, HIV and syphilis, plus TB in high prevalence settings (>100/100,000 incidence), Ax fetal growth with SFH & US <24/40

Answer 103

Treat asymptomatic bacteriuria, antihelminthic treatment in endemic areas (>20% incidence), tetanus vax, intermittent preventive treatment and insecticide treated nets in malaria endemic areas

Answer 104

N&V, reflux, cramps, low back/pelvic pain, constipation, varicose veins & oedema

Answer 105

Woman-held case notes, midwifery-led continuity of care, task shifting, support to recruit and retain healthworkers in rural/remote areas

Answer 106

Participatory learning and action cycles: increase communication and support, birth preparedness, increased use of antenatal services and skilled care, increase male involvement, build partnership with traditional birth attendants

Answer 107

T1 <110, T2/3 <105, PP <100, prevalence 40% globally higher SE Asia & Africa. Causes: pregnancy physiology (haemodilution), nutritional deficiency (90% due to iron def), parasitic helminth infections, other infections (TB, HIV, Malaria), Chronic diseases, acute/chronic blood loss, haemoglobinopathies. Complications: Fatigue/SOB, Immune dysfunction, placental abruption, PPH (reduced uterine contraction), increased maternal mortality. Fetal complications: preterm birth, low birth weight, increased infant mortality. Management oral iron, folic acid +/-B12

Answer 108

Extreme <28, Very 28-32, Mod/late preterm 32-37w. 5-18% of births globally, increased burden in Asia and sub-Saharan Africa, 13.4 million babies in 2020. Causes: idiopathic, iatrogenic (early delivery by healthcare to treat PET, growth restriction), preterm prelabour ROM, infection (intra and extrauterine), bleeding (APH), multiple pregnancy. Preterm birth is a leading global cause of perinatal mortality (30%)

Answer 109

Maternal: demographic (low BMI, age<18 >35yo, black), lifestyle (smoking, drugs, stress, DV), psychological stress, low SES, history of spontaneous preterm, LLETZ, uterine anomaly. Pregnancy: uterine overdistension (multiple pregnancies, polyhydramnios), interpregnancy interval <6m, fetal anomaly, antepartum haemorrhage, PPROM in current pregnancy, Infections UTI/BV

Answer 110

Optimal antenatal care: nutrition and lifestyle, identify and treat anaemia, asymptomatic bacteriuria, US to determine GA and multiple pregnancy, cervical length monitoring, progesterone and cervical cerclage

Answer 111

Tocolysis (Nifedipine) to allow antenatal corticosteroids or transfer to a facility for care, 24-34/40, contraindicated with PV bleeding, placental abruption and intrauterine infection. Antenatal steroids 24-34/40 if high chance of labour within 7d, antibiotics for PPROM <37/40, MgSO4 30% reduction in CP<32/40, delayed cord clamping, thermal care (plastic bag/wraps for stabilisation and transfer)

Answer 112

Can be pre-existing, pregnancy-induced, or PET (HTN & proteinuria) - BP and urine should be checked at every point of contact in pregnancy

Answer 113

Reduced by low-dose aspirin if one high or two moderate risks. PET/HELLP can affect any organ system, seizure in pregnancy is eclampsia until proven otherwise, needs prompt and careful control of HTN, meticulous fluid balance, seizure prophylaxis with MgSO4 Have an eclampsia box wherever you work. Use the post-partum period for pre-pregnancy planning. Pre-eclampsia has a recurrence rate of 10-40% but usually occurs 2-3 weeks later

Answer 114

Good quality ANC can reduce maternal morbidity and mortality from both direct and indirect causes. 'Simple' conditions like anaemia in pregnancy can have a big impact on maternal and neonatal outcomes. Preterm birth is the leading cause of perinatal mortality globally.

Answer 115

Stating the nature of the emergency improves outcomes, look after primips and the multips will look after themselves, deliver only when the intrauterine environment is more hostile than the neonatal cot, the sun should not rise and set twice on a woman in labour. Antepartum haemorrhage APH - get ready for the PPH. PPH - a contracted empty uterus does not bleed. Young fit women will decompensate late. Can be difficult to identify in labour and postnatally. Breech delivery - hands off the breech. Shoulder dystocia - don't just pull. Cord prolapse - elevate the presenting part

Answer 116

Manual uterine displacement. If cardiac arrest, think about perimortem C-section - it will create 30-40% return of blood flow

Answer 117

Placenta implanted totally or partially in the lower segment of the uterus, more common in multiple pregnancy and previous Caesarean, recurrent bright red bleeding without pain, fetus is not usually compromised unless major bleed, do not do a vaginal examination, think through C-section delivery - entry and haemorrhage control

Answer 118

Separation from the placental bed of a normally sited placenta, unknown cause, usually pain, bleeding may or may not be present, fetus may be compromised, may lead to maternal shock and DIC. NVD not contraindicated - labour may happen quickly and successfully

Answer 119

Occurs in labour, with pain, bleeding, fetal distress, maternal collapse. RF: VBAC, grandmultiparity, obstructed labour, trauma. Transfer to theatre for Caesarean +/- hysterectomy

Answer 120

Causes: retained placenta, uterine rupture, uterine inversion or atony, genital tract trauma (cervix or vagina), coagulopathy. Management: ABC, call for help, state nature of emergency, uterotonic medications (oxytocin, ergometrine, carboprost, misoprostol PR, tranexamic acid), theatre for manual removal of placenta, urgent suturing, intrauterine pressure with balloon, laparotomy and compression of uterus. Decision for hysterectomy saves lives if all other measures have failed

Answer 121

Give O2 for SaO2>94%, BC, IVAbx, fluid challenge, lactate, measure urine output

Answer 122

Obstetric emergency, bony impaction on pubic symphysis, hard to predict, early recognition with failure to turn as expected, knees to chest to maximise size of pelvic outlet, suprapubic pressure, internal rotational manoeuvres or delivery of posterior arm, prepare for PPH

Answer 123

Loop of cord descends below presenting part, mechanical compression and spasm of cord -> fetal distress/death. RF: Malpresentation (ie head not plugging the pelvis), multiparity, polyhydramnios, prematurity. Management manually elevate the presenting part to allow blood flow, all fours, 500ml in bladder (helps to stop presenting part to come down), turn off any oxytocin, consider tocolysis to transfer to theatre,

Answer 124

Neonatal conditions are amongst the leading causes of child mortality, and are responsible for almost half of all deaths under 5 years. The highest risk of death is the day of birth, 75% in the first 7 days. Prematurity, birth complications and neonatal infections are the leading causes of neonatal deaths. ‘Every Newborn Action Plan’ lays out strategic objectives and ambitious targets to reduce neonatal mortality NMR or <12 per 1000 births. Neonatal conditions are associated with an increased risk of developmental delay and disability. Important to think ‘Beyond Survival’ … to survive AND THRIVE including early intervention for young children with developmental disability

Answer 125

Extreme <28, Very 28-32, Moderate 32-34, Late 34-37

Answer 126

LMIC 32/40 50% mortality, HIC 24/40 50% mortality

Answer 127

Assessing gestational age, providing warmth, feeding and fluids, infection prevention, recognition and treatment, respiratory support, prevention of apnoea, high patient to nurse ratio

Answer 128

Greatest risk for mortality. Stop producing surfactant, increased respiratory distress. Use more energy, increased glucose requirements, become hypoglycaemic and have increased risk for apnoea

Answer 129

Dry and cover, avoid bathing, put on a hat and a nappy, skin to skin

Answer 130

Reduces mortality up to 25% in trial, risk of sepsis (if occurs is less severe), improves weight gain, higher success in establishing breast feeding, maternal bonding, and reduced time to discharge

Answer 131

Reduces risk of sepsis, NEC, retinopathy of prematurity, feeding intolerance, neurodevelopmental delay

Answer 132

Implementation of a low-cost hospital based neonatal care within the existing healthcare system can have a significant impact on neonatal mortality in a resource- limited setting. Focusing on simple, affordable and sustainable care can have a HUGE impact on neonatal survival. We must FOCUS on educating and training the nursing staff. Education is key

Answer 133

Preterm birth, intrapartum-related birth complications, neonatal infections, birth detects, neonatal jaundice

Answer 134

Potential severe bacterial infection - meningitis, sepsis, pneumonia, tetanus with increased risk for those born at pre-term with complex outcomes of neurological, neurodevelopmental and hearing deficits - these may or may not have effects upon physical and mental health, some of these effects may predispose to early death

Answer 135

First 72h of life, pathogens exposed to before or during birth, may originate from maternal genital tract, unhygienic delivery practices and unclean birth area

Answer 136

NICU admission, invasive procedures (IVC, mechanical ventilation), administration of stock solutions, contaminated equipment, IV or enteral solutions, prolonged hospitalisation

Answer 137

Poor hygiene practices in the home setting, inadequate cord card, bottle feeding instead of breastfeeding, lack of exclusive breastfeeding. Preventive measures exclusive breastfeeding and proper handwashing

Answer 138

Detection: improved lab support, rapid response, POCT. Antimicrobials: treatment protocols, current local/regional epi. AMS. AMR: vectors of transmission, surveillance. IPC: environmental and hand hygiene, context-specific guidelines. Investment: resources and research

Answer 139

Intrapartum Abx: Pen, Azith, Vaccines: RSV, Pneumococcus, GBS. Other: Handwashing, umbi and eye care, breastfeeding, removing lines as soon as not required, strict asepsis for all procedures

Answer 140

First week of life, leading cause of sepsis in neonates, can also cause pneumonia, meningitis, generally acquired by fetus inutero or during birth

Answer 141

1-4 weeks of life, wider clinical spectrum, may cause meningitis, sepsis, septic arthritis, osteomyelitis, pneumonia

Answer 142

South Asia: RSV, Ureaplasma, K pneumoniae, E coli. Sub-Saharan Africa: S aureus, Klebsiella sp, E coli

Answer 143

Birth asphyxia: Failure to initiate breathing at birth. Intrapartum-related death (& stillbirth) ‘Death as a result of damage to the brain and other vital organs from oxygen deprivation around the time of delivery’, Neonatal encephalopathy: A disturbance of neurological function: newborn brain dysfunction, Hypoxic ischaemic encephalopathy: implies causality and is out of vogue

Answer 144

Prematurity 16%, Pneumonia 13%, intrapartum related 11%, diarrhoea 8%, neonatal infection 7%

Answer 145

Different exposures context and care settings, care largely supportive, minimal capacity for investigations, low nursing ratios with minimal monitoring, risk of compounding brain injury (cooling not universally implemented), limited access to fit-for-context equipment (pumps), supply chain challenges and drug shortages, inconsistent electricity and water supplies

Answer 146

Mild: hypertonic, hyperalert (staring), partial primitive reflexes, irritable, hand clenching, voracious or poor feeders. Moderate: hypotonic, lethargic, don't feed, absent primitive reflexes, strong distal flexion, apnoeas, seizures. Severe: completely floppy, comatose, apnoeic, decerebrate, absent reflexes, full fontanelle

Answer 147

Phenobarbitone, followed by phenytoin

Answer 148

Controversial - not universally implemented in LMIC due to limited resources and evidence. Passive cooling common. Challenges: lack of data from SSA with no NICU facilities, comorbidity with perinatal infection/inflammation may impact effectiveness, likely higher prevalence of chronic partial hypoxic ischaemia due to quality of intrapartum care and lack of fetal monitoring

Answer 149

Neurodevelopmental impairment in 29.3%, Cerebral palsy in 19%, most commonly four-limb spasticity. Among those with disability malnutrition common - 44.1% had undernutrition, 32.4% with microcephaly. Clinical risk factors for impairment included: Neonatal clinical seizures, feeding difficulty at discharge, Small head circumference at one year and Abnormality on cUS

Answer 150

Neonatal conditions substantially contribute to death and disability globally. Highest burden is in sub-Saharan Africa ‘where there is no NICU’. Neonatal target populations differ in perinatal exposures and care context meaning HIC interventions can’t be universally applied. Predictors of adverse outcome useful to inform targeted follow-up, and future trials, however more locally implementable tools are needed. Few comprehensive neurodevelopmental assessment tools have been validated in LIC populations. Early care and support programmes are crucial and will need to be integrated with routine government services for sustainability at scale

Answer 151

1 No Poverty, 2 Zero Hunger, 3 Good health and wellbeing, 4 quality education, 5 gender equality, 6 clean water and sanitation, 7 affordable and clean energy, 8 decent work and economic growth, 9 industry, innovation and infrastructure, 10 reduced inequalities, 11 sustainable cities and communities, 12 responsible consumption and production, 13 climate action, 14 life below water (aquatic), 15 life on land, 16 peace, justice and strong institutions, 17 partnerships for the goals,

Answer 152

Faeces -> fluids, fingers, flies, fields -> food -> new host. Sanitation, safe water and hygiene/handwashing can break the onward transmission

Answer 153

Started in western Europe in 19th century, resulted in sanitary policies and actions across western Europe and North America. Significant decline in diarrhoea deaths, particularly among infants and young children. 1866 The Great Sanitary Act

Answer 154

1854 John Snow

Answer 155

"the safe disposal of excreta and human faeces to protect the health and contamination of the environment”. (UN Water 2008)

Answer 156

“the safe containment, transport, treatment and disposal/re-use of human excreta”. (UNICEF definition)

Answer 157

Safely managed: use of improved facilities which are not shared with other households and where excreta are safely disposed in situ or transported and treated off-site. Basic: use of improved facilities which are not shared with other households. Limited: Use of improved facilities shared between two or more households. Unimproved: use of pit latrines without a slab or platform, hanging latrines or bucket latrines. Open defaecation: disposal of human faeces in fields, forests, bushes, open bodies of water, beaches and other open spaces or with solid waste

Answer 158

Advantages: Easy to build, Low cost (capital and operating). Disadvantages: Flies and odours, Needs emptying, Difficult to clean, Excreta is visible, Requires treatment of sludge, Pits are susceptible to overflowing during floods and can collapse, Stagnant water in pits may promote mosquito breeding, Leachate can contaminate groundwater

Answer 159

Advantages: Easy to clean, More structurally stable, Easy to build, No need for constant source of water, Low capital and operating costs. Disadvantages: Flies and odours, Needs emptying (cost), Requires treatment of sludge, Leachate can contaminate groundwater

Answer 160

46% of the world do not have safely managed services, and 20% (1.7 billion people) lack basic sanitation services

Answer 161

Containment > Emptying > Transport > Treatment > Reuse/disposal

Answer 162

Consumer concerns: cost of dealing with it, visible excreta, flies and smells, social embarrassment, access to emptying services

Answer 163

Improved vs unimproved - 16% reduction in diarrhoea, however effect of sewered vs unimproved 40% reduction in diarrhoea

Answer 164

Provides privacy, More convenient, Save time, Cleanliness and smell, Increases school-attendance, Don’t have to withhold food/drinks, Prevent imprisonment by daylight, Protection from harassment & rape, Avoid dangers at night, Avoid snakes, Increase value of property/tenant's rent

Answer 165

Issues: pain and discomfort, stigma, lack of privacy, decreased self-esteem and social participation. Accessing sanitation was among the top challenges of daily living among people with disabilities in Malawi

Answer 166

Surface water: Drinking water from a river, dam, lake, pond, stream, canal or irrigation canal. Unimproved: drinking water from an unprotected dug well or unprotected spring. Limited: drinking water from an improved source for which collection time exceeds 30 minutes for a round trip, including queuing. Basic: drinking water from an improved source, provided collection time is not more than 30 minutes for a round trip, including queuing. Safely managed: drinking water from an improved water source that is located on premises, available when needed and free from faecal and priority chemical contamination

Answer 167

A source that by nature of its construction or through active intervention, is protected from outside contamination, in particular from contamination with fecal matter

Answer 168

Piped water into dwelling, piped water into yard/plot, public tap/public standpost, tubewell/borehole/hand pump, protected dug well/spring, protected spring, rainwater

Answer 169

Collected surface water, unprotected dug well, unprotected spring, tanker truck/cart with tank

Answer 170

Free from contamination, accessible on premises, available when needed

Answer 171

>30 minutes - water consumption drops and therefore decreased hygiene practices. A 15 min decrease in roundtrip water collection time is associated with 41% reduction in diarrhoea and 11% reduction in under-5 child mortality

Answer 172

Chlorination (not effective Giardia or Crypto), Boiling, Filtration (slow sand filters), UV disinfection

Answer 173

Description: you drink it. Example: Cholera. Interventions: Improve drinking water quality, improve sanitation

Answer 174

Description: Person-to-person transmission due to inadequate personal and domestic hygiene. Example: trachoma, conjunctivitis, louse-borne typhus. Interventions; Increase quantity of water. Improved hygiene by increasing access and availability of water

Answer 175

Description: Transmission of infections via an obligatory aquatic host (eg snail). Example: Schistosomiasis, guinea worm. Interventions: decrease contact with contaminated water. Control aquatic animals. Reduce excreta entering environment

Answer 176

Description: Transmission by insects which breed in (or bite near) water. Example: Malaria, dengue, yellow fever, sleeping sickness, filariasis. Interventions: Eliminate breeding sites, netting, repellent, keeping people away from breeding sites

Answer 177

Water ladder for service level: from surface water to safely managed. Minimum for 'basic' access according to WHO: improved source and available within 30 minutes (round trip. Safe water can prevent waterborne and water-washed diseases (water quality and quantity), non-health benefits mainly for women and children

Answer 178

Diarrhoeal disease reductions of 30%, acute respiratory infection reduction of 11%. Averted 607,000 deaths of children under 5 annually

Answer 179

1 Before touching a patient, 2 before clean/aseptic procedure, 3 after body fluid exposure risk, 4 after touching a patient, 5 after touching patient surroundings

Answer 180

39% of healthcare professionals globally manage to wash their hands at WHO 5 key times. 35% of health facilities in LMIC do not even have water and soap available for handwashing

Answer 181

Need significant acceleration to achieve targets of drinking water, sanitation, and hygiene

Answer 182

Death due to illness

Answer 183

Consequences and complications (other than death) that result from a disease

Answer 184

Rotavirus, Cryptosporidium, enterotoxigenic E coli, Shigella. Diarrhoeal mortality has decreased, but morbidity is still very high. Repeated diarrhoea has impact on growth curve

Answer 185

Inhibits nutrient absorption -> malnutrition, even if sufficient nutrition is consumed. Reduces resistance to infections. Early childhood development including stunting and wasting. Cognitive development (eg language and memory), lifelong consequences, such as productivity or ability to learn

Answer 186

Inflammation of small intestine, marked by alterations in gut lining - as a result of diarrhoea disease. Also reduces absorption of oral vaccines

Answer 187

Drinking water: 33% RR (75% RR if treated water is piped to premises), Sanitation: 25% RR (45% RR if >75% sanitation coverage), Hygiene: 30%

Answer 188

Consult with the communities - what do they want/need, and what can they afford? Onsite sanitation is probably a better/cheaper solution and will reach more people. Addressing child faeces disposal with child-friendly latrines and education. Health education not likely to work - improving sanitation coverage will need promotion of sanitation as part of the approach. Provide water vendors with means to treat water, build more boreholes in the rural areas. Think about where the waste from latrines goes - can it be treated or reused? Poor household would likely not connect to an expensive system, particularly if there is abundant free water and sanitation is rarely a priority.

Answer 189

Production based (reduced harvest), Trade based (import bottlenecks), Labour based (poverty, unemployment), Transfer-based (late delivery of food aid, profiteering)

Answer 190

Consider not just maternal and child nutrition, diets/care, food, feeding and environments, but also consider resources, and governance. Resources: sufficient resources include environmental, financial, social and human resources to enable children and women's right to nutrition. Norms: positive social and cultural norms and actions to advance children's and women's right to nutrition. Governance: includes political, financial, social and public and private sector actions - to enable children's and women's right to nutrition

Answer 191

Xerophthalmia is the clinical spectrum of ocular manifestations of vitamin A deficiency; these range from the milder stages of night blindness and Bitot spots to the potentially blinding stages of corneal xerosis, ulceration and necrosis (keratomalacia). An estimated 250 000–500 000 children who are vitamin A-deficient become blind every year, and half of them die within 12 months of losing their sight. Deficiency of vitamin A is associated with significant morbidity and mortality from common childhood infections, and is the world’s leading preventable cause of childhood blindness. Vitamin A deficiency also contributes to maternal mortality and other poor outcomes of pregnancy and lactation. It also diminishes the ability to fight infections. Even mild, subclinical deficiency can be a problem, because it may increase children's risk for respiratory and diarrhoeal infections, decrease growth rates, slow bone development and decrease the likelihood of survival from serious illness.

Answer 192

Generally wasted, thin arms (mid upper arm circumference), thin face, ribs visible, sunken eyes, lack of skin turgor (difficult to assess hydration)

Answer 193

Bilateral pitting oedema, apathetic, sparse/discoloured hair, dermatosis, enlarged liver, angular cheilitis

Answer 194

Normal = +/- 2SD median. Moderate (MAM) = -2-3 z-scores or MUAC<125mm without oedema; Severe (SAM) <-3 z-scores or MUAC <115mm -> marasmus (severe wasting) with oedema -> Kwashiorkor

Answer 195

GORD, inadequate breast milk supply or ineffective latching, incorrect formula preparation, mechanical feeding difficulties (cleft lip or palate), neglect or abuse, poor feeding habits, poor oral neuromotor coordination, toxin-induced gastrointestinal upset (eg lead levels leading to anorexia, constipation or abdominal pain)

Answer 196

Anaemia (iron deficiency), biliary atresia, celiac disease, chronic gastrointestinal conditions (irritable bowel syndrome, infections), cystic fibrosis, inborn errors of metabolism, milk protein allergy, pancreatic cholestatic conditions

Answer 197

Chronic infection (HIV/AIDS, TB), chronic lung disease of prematurity, congenital heart disease, hyperthyroidism, inflammatory conditions (eg asthma, inflammatory bowel disease), malignancy, renal failure

Answer 198

METABOLISM: Metabolic rate -24% and Protein synthesis -37%. VITAL ORGANS & SYSTEMS: Heart / Cardiovascular: Output -31%, Anaemia (decreased production /increased loss RBC), Kidneys: Glomerular. Filtration rate -41%, Sodium excretion -54% Liver: Fatty liver (+++ in kwashiorkor; (+) in marasmus), decreased endogenous glucose production. Pancreas: decreased Beta cell function, decreased enzyme production (NB. amylase trial). Hormonal: decreased Thyroid function, decreased Cortisol, growth hormone responses. Gut: Atrophy, decreased Nutrient absorption (even though increasing the feeding), Chronic Inflammation, Microbiome changes (?interventions). Skin: decreased barrier role, decreased subcutaneous fat (decreased insulation), decreased collagen / protein ‘reserve’. Immune function: Greater vulnerability to infection, Atypical (decreased) response to infection, Atypical manifestations of infection, Poorer outcomes from infection. Brain / Central Nervous System: Relatively protected but…Lethargy, irritability, Decreased appetite, Decreased interaction with environment

Answer 199

Usual signs do not apply - skin turgor can represent loss of subcut fat, sunken eyes can represent loss of retroorbital fat and dry mouth/eyes may represent atrophied glands. Better to assess for recent changes in turgor, eyes, dry stat, in addition to input/output (charts) urine/stool, weight changes, thirst, conscious level

Answer 200

Treatment with great care: risk of heart failure/worsening, oral/NGT whenever possible, specially formulated solutions, monitor response clearly (weight, vitals, fluid in/output, alert) - pause/slow fluids if worsening. Prevention is better (early feeds, ORS, breastfeeding)

Answer 201

Infection - assume infection and give Abx. Phase 1 (Stabilisation) small volumes (total and per feed), frequent feeds, light/easy to digest and metabolise (oral whenever possible), may need nasogastric tube if not tolerating -> Transition phase -> Phase 2 (Rehabilitation) larger volumes (total and per feed), less frequent, nutrient dense

Answer 202

Community Management of Acute Malnutrition - provides improved access, higher coverage, less opportunity cost for parents in attending, and earlier intervention for affected children. Made possible by ready-to-use therapeutic foods that are locally made, acceptable, accordable with no preparation needed - can be given at home. Assisted by patient-held card with improved records, improved clinical care, and therefore information on previous treatment - includes weight, height, MUAC, target weight (85 & 90%), oedema, assessment of marasmus/kwashiorkor/moderate, treatment with vitamin A (x2), albendazole, and discharge weight

Answer 203

Children: good for patients, prefer home treatment, decreased nosocomial infection, decreased AMR, decreased hospital costs, Carers: Prefer home treatment, time for other children, time for other home duties, earlier presentation, less absconders. Community: empower communities, improves impact, begins to address the root causes

Answer 204

Neonatal disorders, Pneumonia, Diarrhoeal diseases, Congenital defects, Malaria (next 5 = meningitis, malnutrition, STDs, whooping cough, measles)

Answer 205

Major issue is resource allocation, O2 concentration, access to oxygen

Answer 206

Cylinder: produced in manufacturing plants, needs regular refilling, often means intermittent supply. Concentrators: extract nitrogen from air in the atmosphere to leave O2, done at the bedside, can supply up to 5 patients with flow splitters, need constant electricity, need cylinders as backup in case of power-cuts. Central piped O2 pied from large O2 source, but high cost, usually only in central hospitals

Answer 207

Very high: central cyanosis, decreased conscious (PU), grunting with every breath, nasal flaring, severe palmer or conjunctival pallor, acute coma or convulsions >15 min. High: inability to drink or feed. Priority: severe chest indrawing, RR>=70, head nodding

Answer 208

In areas where oxygen supply is limited it is only given to the sickest children. These children tend to die at a higher rate than children not on oxygen. This leads to a common belief amongst parents that it is the oxygen that caused the death. This can be difficult to overcome. Strategies include: gentle discussion with a trusted healthcare professional from the same community, demonstrate O2 use on yourself, use of sats probe if available to show increase in oxygen levels in the blood

Answer 209

Cough 2w, Night sweats 2w, loss of weight/failure to gain as expected

Answer 210

CXR +/- other imaging if clinically indicated. Molecular WHO-recommended rapid diagnostic eg Xpert MTB/Rif, Xpert Ultra, LAMP, Trunat on sputum/induced sputum, early morning GA, Stool, NPA, Biopsy samples eg of LN, CSF if LP

Answer 211

Non-severe: non-cavitatory, non-miliary PTB in one lung lobe, or peripheral LN TB or intrathoracic LN TB without airway obstruction, or simple TB pleural effusion. Rx 2HRZ[E]>2HR (SHINE Trial NEJM 2022)

Answer 212

All asymptomatic household contacts should be offered TPT. Children <5 and LMHIV particularly high risk are target populations for TPT - options are 6H, 3HR

Answer 213

Bedaquiline, delamonid, linezolid, levofloxacin, clofazimine BDLLfxC regimen (Need MDT discussion to treat MDR)

Answer 214

Levofloxacin

Answer 215

Sucking movements, moving hands (neonates have no purposeful movements),

Answer 216

Fast breathing (RR>60), severe chest in-drawing, fever >38, hypothermia <35.5, no movement at all or movement only on stimulation, feeding poorly or not feeding at all, convulsions

Answer 217

Ix: BC, LP if safe, malaria RDT, BM if available. A: support if needed (neutral head position, chin lift), B: O2 (0.5-1L/min) via NP if seizing/resp distress and available, C: NG feeding EBM if not breastfeeding, D treat low BM (2-5ml/kg 10% dextrose IV or NG) phenobarbitone for seizures (then phenytoin or benzos if needed - benzos not first line as tendency for apnoea), E: keep warm - hat KMC. Phototherapy for jaundice if available - if not then transfer, if not possible, sunlight. IV Abx - go on local resistance pattern/local guidelines if available. If unknown Amp and gent, if meningitis concerns add 3rd gen cephalosporin

Answer 218

Is the child severely malnourished? Is the child shocked? How dehydrated is the child?

Answer 219

Signs not meeting some/severe dehydration: WHO treatment plan A ORS <1yo 50-100ml/loose stool >1yo 100-20ml/loose stool, zinc

Answer 220

2 or more of: restless/irritable, sunken eyes, thirsty/drinks eagerly, skin pinch goes back slowly. WHO Treatment plan B: ORS in hospital over 4h, home if tolerates, zinc po, treat as 7.5% fluid deficit

Answer 221

2 or more of lethargy or unconsciousness, sunken eyes, unable to drink or drinks poorly, skin pinch goes back very slowly (>2sec). WHO Treatment Plan C: IV or NG rehydration (30ml/kg over 30-60min, then 70ml/kg over 2.5-5h + 5ml/kg/h ORS when tolerates oral). hospital admission, zinc po, treated as 10% fluid deficit

Answer 222

Rotavirus, Shigella, ST-ETEC, cryptosporidium and enteropathogenic E coli

Answer 223

Challenging in resource-limited settings: options: in-line burettes (not commonly found, cheap but single use). Drop rates: most common method ~20 drops/ml clear fluids, ~15 drops/ml blood. Issues: high risk of over/under hydration due to incorrect drip rates and lack of availability of paediatric size fluid bags. Alternatives: NG administration. Issues: placement checking (lack of pH strips/CXR availability), persistent vomiting, lack of absorption, aspiration risk, tolerability issues

Answer 224

1 replace lost fluid and give extra for ongoing losses. 2 feed early and extra (only withhold food in initial fluid replacement phase), 3 zinc po 14d (though limited evidence, no evidence <6m) 4 advise when to return (worsening/fever/blood in stool/persistent diarrhoea)

Answer 225

Initial: hypoglycaemia, hypothermia, dehydration, stabilisation: electrolytes, infection, micronutrients (without iron), initiate feeding, sensory stimulation. Rehabilitation: Continue electrolytes, micronutrients (with iron), catch-up feeding, continue sensory stimulation, prepare for follow up

Answer 226

U does not equal U (promise study)

Answer 227

<18m look for virus (DNA, p24 Ag) >18m EIA

Answer 228

Screen for TB and other opportunistic infections and test/treat if present - delay ARVs for as short a time as possible (<2-8w) following TB/OI treatment commencement. Start ARVs according to national guidelines. Daily cotrimoxazole prophylaxis for all children <1y (older children if CD4 <25%/200 or WHO stage 2, 3, 4), TPT if TB contact and not concerned about active TB disease. Baseline bloods and CD4 count for monitoring purposes. Support parents and family.

Answer 229

Clinical: prostration, confusion/agitation GCS<11, Coma (GCS<3 or Blantyre <3), respiratory distress (acidotic breathing), convulsions, shock (prolonged cap refill or sBP<80 in adults <70 in children, pulmonary oedema, abnormal bleeding, jaundice, anuria, repeated vomiting. Laboratory Hb <7 adults <5 children. Haemoglobuinuria, hypoglycaemia (BSL<2.2), acidosis, AKI, asexual parasitaemia >10% of infected RBCs)

Answer 230

Responds only to voice or pain/unresponsive, acute confusional state, sBP<90 (or drop >40), HR >130, RR>25, Need oxygen to keep SaO2>92%, non-blanching rash, mottled/ashen/cyanotic. Not passed urine in last 18h, UO<0.5ml/kg/h. Lactate >2, Recent chemotherapy

Answer 231

Key point: RDTs can remain positive with recent malaria treatment. Fever and positive RDT within a few weeks of recent treatment (?reinfection ?treatment failure ?persistent antigen but no malaria (if using PfHRP2)). Need microscopy or LDH-based RDT. If current infection confirmed WHO suggests: <4w from previous infection - assume treatment failure, give 2nd line antimalarials. If >4w from previous infection - treat as new infection but consider different oral agent if available). If severely unwell and delay in getting microscopy/LDH RDT treat as severe malaria and other causes eg sepsis until results known

Answer 232

Malaria parasites in blood should be treated for malaria, but this doesn't necessarily mean that the child has cerebral malaria (though you can also have cerebral malaria with low parasitaemias)

Answer 233

Retinal fundoscopy: patchy retinal whitening, focal changes of vessel colour, retinal haemorrhages often white centred +/- papilloedema

Answer 234

Parasitaemia in endemic areas is common and not always causative. Post-mortem studies - up to 1/3 of children dying with presumed cerebral/severe malaria actually died from something else: most often bacterial infections. Malaria also increases the risk of serious bacterial infections, esp NTS. As it is mainly impossible to tell at the outset whether a seriously unwell child with positive RDT/film has severe/cerebral malaria or a serious bacterial infection you mostly need to treat for both. We desperately need point of care diagnostics that can accurately distinguish malaria vs bacteria vs viral causes of pathology

Answer 235

A: Recovery position, airway adjuncts. B: O2 if available (coma/shock), C: IV access - RDT/film, BC, FBC (at minimum if available then BM, UE, LFT, Gas, G&S) - IV artesunate (if malaria), IV broad spectrum abx, maintenance fluids. D: treat for hypoglycaemia if BM unknown. E: antipyretics, LP when stable. Consider nutrition if prolonged coma

Answer 236

Feast trial - 3.3% greater risk of 48h mortality with any bolus given

Answer 237

O2 use and prioritisation can be challenging. Fluids can be dangerous and need to be prescribed and administered carefully. Malaria parasitaemia is common in endemic areas and may not be why the child is unwell: treat it, but also investigate/treat other causes. Even healthcare that is free at point of access can have catastrophic indirect costs for families. Much of what we thin we know to be correct in medicine (particularly in paediatrics) has never been properly tested. Be curious, engage in research and advocate for the best possible evidence base for every patient you see!

Answer 238

Cough. No Ix (consider malaria RDT if febrile in endemic area +/- opportunistic HIV test). Management: home, conservative, check weight, immunisations and deworming. Advise when to return, follow up in 5 days if not improving

Answer 239

Cough & tachypnoea, some mild chest indrawing allowed. No Ix (consider malaria RDT if febrile in endemic area +/- opportunistic HIV test). Management: home, oral abx, check weight, immunisations, deworming, advise when to return, follow up in 3 days

Answer 240

Cough & tachypnoea + danger sign (severe resp distress, grunting, severe chest indrawing, SaO2<90 on air or central cyanosis, inability to feed/drink, reduced consciousness/lethargy/convulsions). Ix Consider CXR, BSL if reduced conscious/convulsions, SaO2 if available. Management: admit, O2 therapy if known low sats, central cyanosis or severe resp distress, IV Abx, Care with fluid balance. Antipyretics if child distressed, bronchodilators if wheeze.

Answer 241

Brandt line, best term is 'low-resource settings' (do not use third world. Terms out of vogue include global south, developing, low-income countries). Consider equity

Answer 242

Repercussions of early childhood inequities are far reaching and long lasting. Focus on equity in policy formulation and programme implementation. Use data to target interventions towards undeserved groups. Remove access barriers (cost, availability, distance) through targeted outreach, mobile services, removing user fees, support for child health workers. Address socioeconomic determinants through multisectoral action (eg female education), cash transfers

Answer 243

Multiple disease-specific and integrated interventions: HIV/malaria prevention and treatment, expanded vaccination IMCI (integrated management of childhood illness) (ETAT is used for inpatients). Investment in health systems: free/subsidised healthcare for mothers and young children, training CHW for prevention and basic care, infrastructure, equipment, supply chains, quality standards, data availability and use. Cross-sectoral collaboration addressing malnutrition, water and sanitation, income. Governance: Sustained, high-level political commitment, stakeholder involvement, partner coordination.

Answer 244

Focus on prevention: this age group is ideal for health interventions due to increased independence and lifestyle habit development, Scheduled well child visits: ensuring scheduled health contacts for older children is key, as they are less likely to seek care when critically ill. Interventions with potential: priority interventions for children aged 5-9 include school feeding, micronutrient supplementation, health education, vision screening, deworming, mass drug administration for trachoma, vaccine catch-up and mental health support, Delivery platforms: primary care services and outreach, schools and childcare centres, home and community platforms, child and social protection services, digital platforms

Answer 245

Integrated approach: NCDs, mental health, injuries, sexual and reproductive health, nutrition, communicable disease and wider determinants. Strengthening health systems and multisectoral work (horizontal rather than vertical approaches)

Answer 246

Nourished, stimulated, safe, secure and loved

Answer 247

Survive (end preventable deaths), thrive (ensure health and wellbeing), transform (expand enabling environments)

Answer 248

Polio vaccines and eradication. DTP vaccines (83% coverage), MMR vaccines and ongoing measles outbreaks. MenAfriVac and African Meningitis Belt, HPV vaccines and cancer prevention. Money vs disease burden (rotavirus), Political commitment to invest in vaccines. War and Civil unrest. International commitment: GATES and PATH

Answer 249

90% protection against pertussis disease and 97% protection against death from pertussis in the first 2 months of life. The acellular pertussis however does not stop infection, it just minimises the illness

Answer 250

1 in 3 women will experience physical and/or sexual violence by a partner or sexual violence by a non-partner. Child sexual abuse 20% of girls (5% raped), female genital mutilation 'FGM' 125 million, forced early marriage 60 million

Answer 251

2/3 of those who experienced sexual abuse before 18y told someone in authority about it…fewer than 10% received professional services

Answer 252

Clinical officers/doctors trained in diagnosis of CSA, services for women and children, 24/7 access to PEP/VCT/EC, social worker/community child protection worker - ensure place of safety, police victim support, volunteer led child trauma counselling

Answer 253

Patriarchal systems, initiation ceremonies, victim blaming, limited education, normalisation of violence, corruption and impunity, silence and stigma, societal hierarchies

Answer 254

Support: comfort, listen, letting them know they are believed, helping them make informed decisions, exploring coping mechanisms, building family and community supports - these enhance ability of survivor to cope and prevent the distress from developing into serious mental illness. Challenges: limited staffing resources, insufficient education on trauma-informed care and survivor-centred approach, difficulty establishing trust, long process for survivors to get help, societal attitudes (personal biases) affecting support, empathy fatigue, perpetrator and survivor close relationships

Answer 255

Which trimester, duration of therapy, is treatment necessary, is the drug orally absorbed, can another route be used, what is the likely duration of exposure, is anticipated effect known and measurable, can effects of the drug be safely monitored?

Answer 256

Absorption: reduced gut motility, increased lung function, increased skin blood circulation. Distribution: increased plasma volume, body water, and fat deposition affecting volume of distribution. Protein binding - decreased plasma proteins. Metabolism: hepatic enzyme activity could be increased (maternal hormones). Excretion: increased glomerular filtration rate, gastric motility reduced.

Answer 257

Distinct from medicines use in pregnancy, most medicines are unlicensed for use in breastfeeding, information is sparse on the effects so often prefer older medicines that have more data (observational), ensure you know how to give the information and whoever receives it to repeat what you said. The benefits of breastfeeding and maternal bonding. Drugs licensed for use in children unlikely to be a problem, avoid breastfeeding only if there is no suitable alternative drug. Where possible use drugs and dosing regimens that will minimise infant exposure. Monitor infant - especially if premature

Answer 258

Withhold or delay therapy if possible, use a drug with poor penetration into milk, use an alternative route of administration, avoid nursing at peak drug concentrations, give drug before infant's longest sleep, as a last resort - 'pump and dump' milk if short courses or discontinue breastfeeding - needs to be individualised

Answer 259

Before initiating anything ensure patient is aware of risks. Mitigate where possible - delay/withhold if therapy known to cause problems. Do not suggest patient stops taking regular medication before checking first. Vitamin D supplementation is currently recommended within the first weeks after birth and during breastfeeding - but incurred cost does not support its use for all breastfed term infants.

Answer 260

Risk of TB to mother and child outweighs risk to treatment. First line anti TB drugs cross the placenta but do not appear to be harmful. Second-line anti TB drugs more risky, avoid streptomycin (ototoxic to fetus). Continue breastfeeding (low concentrations of anti-TB drugs present)

Answer 261

Risk to mother: severe malaria, maternal anaemia. Risk to infant: spontaneous abortion, stillbirth, prematurity, low birthweight - important risk factor for infant mortality, stunting and later life course impacts

Answer 262

In malaria-endemic areas, pregnant women of all gravidities should be given antimalarial medicine at predetermined intervals to reduce disease burden in pregnancy and adverse pregnancy and birth outcomes. Sulfadoxine-pyrimethamine (SP) has been widely used for malaria chemoprevention during pregnancy. Start in second trimester and give three doses at least one month apart

Answer 263

Pregnant women with uncomplicated P falciparum malaria should be treated with artemether-lumefantrine during the first trimester

Answer 264

Artesunate in all trimesters. Once a patient has received at least 24h of parenteral therapy and can tolerate oral therapy, treatment should be completed with 3 days of an ACT. Same as in non-pregnant population

Answer 265

1 Weigh up risks and benefits to mother and fetus - try to keep duration short, ensure good adherence. 2 For pregnant women with active TB, same treatment as in non-pregnant population except avoid streptomycin and the safety of pyrazinamide in fetus unknown. 3 For pregnant women with malaria same treatment as in non-pregnant population except avoid primaquine and doxycycline

Answer 266

Neonate 0-28d, Infant 1-12m, Toddler 1-3y, Child 4-12y, Adolescent 13-19y

Answer 267

Body water and fat content change, gastric pH is high at birth with reduced peristalsis in first 6m and reduced bile production. Neonates have immature skin barrier - large surface area relative to body weight and well hydrated skin = increased systemic absorption more likely (NB excipients eg alcohol content - can cause burns - steroid creams - systemic absorption). Rectal absorption is highly vascular and most of the dose will bypass first pass metabolism but may not be acceptable. Muscle mass low in neonates and infants IM administration may have unpredictable absorption due to reduced/variable blood flow. Use the Schwartz formula in children and young people to calculate renal function - renal excretion is dependent on gestational age, reduced in babies compared to adults, clearance of renally excreted medicines is prolonged in infants.

Answer 268

Are antimicrobials essential, likely organism, local sensitivities, where do they need to act, how quickly, side effects, allergies, interactions, vaccines

Answer 269

Crushing dispersing tablets (this renders them unlicensed, but is common practice), alternate routes, administration with/in food-check pharmacokinetics, pill swallowing techniques, play, ownership, don't assume liquids are always the best option - taste/volume/excipients/preference, dose rounding (+/- ~10%). Counselling - individualised approach, concrete vs abstract thinking with teenagers - do not use ultimatums, understand barriers - timing/school - understanding/reluctance to give, pill size, volume, measurable doses

Answer 270

Difficult to complete trials on children (recruitment/retention), older drugs may not have originally done trials in children, but some have since extended licensing, new drugs must have clinical trials in paeds. >12y and >40kg physiologically ~adult

Answer 271

Different spectrum of infections and drug resistance, different comorbidities, different treatment seeking and other cultural differences, fewer resources (access to medicines, tests, staff and experience), different use of drugs, intermittent/seasonal prophylaxis

Answer 272

Country of origin: poverty, war, conflict, genocide, drought, famine, disrupted healthcare. Journey: exposure, risk, poor sanitation, crowding, poor nutrition, sexual violence. Destination: language barrier, cultural barriers, fear of authority, overcrowding

Answer 273

Stool: OCP microscopy, Giardia PCR. Bloods: FBC (anaemia, eosinophilia), LFTs (in case needs TB Rx), Vit D, IGRA, Serology HBV/HCV/HIV/Syph, Schisto & Strongy. Urine NAAT NG/CT. Recommendation: panel-based approach with additional tailoring based on significant population determinants - there are issues with unpicking exposures due to stigma and people may not tell you everything. If in a setting without ability to test, may be safer and quicker to give empiric albendazole & praziquantel. Often good model of care is to see family groups

Answer 274

TB 18%, Parasites 7-10%, BBV 3% (mostly HBV), Schisto 12% Does it matter? Yes - there is a lifetime risk unless you do something about it (plus the public health implications)

Answer 275

Mental health, hearing and vision health, physical health, oral health, social, safeguarding, sexual and reproductive health, preventive medicine

Answer 276

Physiological needs: air, water, food, shelter, sleep, clothing, reproduction. Safety needs: personal security, employment, resources, health, property. Love and belonging: friendship, intimacy, family, sense of connection. Esteem: respect, self-esteem, status, recognition, strength, freedom. Self-actualisation: desire to become the most that one can be

Answer 277

Control seizures, train to take pills. Manage ICP, steroids (high dose then wean). TB Rx: 2HRZ + fourth agent (streptomycin or levofloxacin) > 7-10HR. Note WHO 2021 allowed for 6m regimen of HRZ + ethionamide in children (Sth Africa have adopted this, UK cannot access ethionamide)

Answer 278

Control seizures, train to take pills. Manage ICP, steroids (high dose then wean). Albendazole 15mg/kg for 10-14d + praziquantel 50mg/kg if >2 viable cysts. No antihelminthics if lots of oedema/raised ICP. MUST have ophthalmological assessment for eye involvement BEFORE starting treatment (risk of blindness with degenerating active cysts)

Answer 279

The differentials for cerebral ring enhancing lesions are broad and diagnosis can be challenging particularly in kids: make friends with a neuroradiologist. Tuberculomas and neurocysticercomas are often classically silent until seizures. Sometimes treatment needs to be presumptive or brain biopsies are required. IGRA/Mantoux can be negative in active TB: IGRAs perform poorly in young children. Care with ethambutol in kids with TBM as difficult to monitor optic neuritis. Treatment duration for TBM in kids is debated - SURE trial ongoing! Poor evidence for treatments (duration, steroids etc) in tuberculomas specifically. Serology in children with single/calcified neurocysticerci has low sensitivity

Answer 280

Often mild/asymptomatic. Febrile phase (fever, rash, retroorbital pain, arthralgia, positive torniquet test). Critical phase (plasma leak, risk of bleeding, shock, commoner in children and more common with second infection or infants 6-12m). Recovery phase: can get prolonged fatigue. Complications: liver failure, CNS involvement, myocardial dysfunction, retinal vasculitis, HLH. Management supportive, WHO stepwise criteria, careful fluid management. Prevention: bite reduction, vaccine

Answer 281

Abdominal pain or tenderness, persisting vomiting, clinical fluid accumulation, mucosal bleed, lethargy/restlessness, liver enlargement >2cm, increased HCT with rapidly decreased Plt

Answer 282

Intracellular, Transmission through bite of scratch from infected cat, exposure to cat fleas of infected cats. Global distribution. Incubation 3-10d, 7-60d for lymphadenopathy. Most commonly localised cutaneous/LN infection (85-90%), PUO, disseminated disease (liver, spleen, eye, CNS), complications: neuroretinitis, encephalopathy, transverse myelitis, osteomyelitis, endocarditis. Diagnosis: IgG most useful with convalescent serology, PCR, culture, histopathology. IgM unreliable. Treatment: localised disease mostly self-resolving, or 5d azithro. Disseminated: Rif/azithro 2-3w, Neuroretinitis - doxy plus azithro (risk benefit conversation about doxy use in childhood - <3 weeks is generally ok)

Answer 283

Always consider ABCDE and isolation in parallel to clinical management and public health notification. Always consider the need to cover for multiple pathogens concurrently

Answer 284

Orthopox, Transmission: contact with lesions, resp droplets (prolonged face to face) and fomites. Sexual. Incubation 5-21d, infectious 4d prior to symptoms and until all lesions epithelialised. Clinical manifestations: fever, flu-like sx, lymphadenopathy, centrifugal maculopapular rash after 3d - spreads all over body including palms, soles, vesicles, pustules. Complications: encephalitis, pneumonitis, conjunctivitis, secondary bacterial infections. CFR 0-11% (endemic areas). Pregnant women - fetal loss. Diagnosis: PCR from vesicle fluid/respiratory samples/blood. Treatment options: supportive, tecovirimat, brincidofovir, cidofovir. Vaccine: 3rd gen MVB-BA not currently licensed for pregnant women or children - though data from UK in children reported good safety and tolerability.

Answer 285

First identified DRC 1970, first reported outside Africa in US in 2003 with sporadic travel associated clusters in countries outside Africa. May 2022 multicountry outbreak of Mpox declared - majority of cases in MSM community (Clade Iib >100,000 >500 children (<1%). September 2023 outbreak of new subclade (Ib) in DRC - sustained human to human transmission. Upsurge in reported cases in DRC, plus transmission to neighbouring countries for the first time - August 2024 WHO declared PHEIC. Clade I Mpox reported to have higher case fatality than Clade II and remains a high consequence infectious disease in the UK. Currently only a few sporadic case of Clade I Mpox outside Africa

Answer 286

High consequence infectious disease - always need to think about it! Remember travel history - including close contacts. Evolving situation - check up to date government websites. Isolate - side room, minimise contacts, log on door, family group etc. PPE, sampling, know who to call - local infection team/microbiology, paediatric ID team, Imported Fever Service

Answer 287

Clinical features <2y present by 3m of life, majority asymptomatic at birth, hepatosplenomegaly and cholestatic jaundice, nasal discharge, rash (palms and soles), condylomata lata, lymphadenopathy, skeletal abnormalities. >2y facial features: frontal bossing, saddle nose, eyes: interstitial keratitis, optic atrophy, keratitis, sensorineural hearing loss, dental abnormalities, palatal perforation, skin: gummas, perioral fissures, CNS: hydrocephalus, CN palsy, learning difficulties, skeletal: saber shins, painless arthritis, paroxysmal cold haemoglobinuria. Key investigations: LP including VDRL and PCR, neuroimaging, imaging of other bones, audiology, ophthalmology review, HIV/HBV/HCV, STI screening and treatment for parents. Treatment procaine penicillin or benzylpenicillin 10d course if symptoms or abnormal Ix

Answer 288

Home, Education, Employment, Eating, Activities, Drugs/Alcohol, Sexuality, Self-harm, Suicide, Safety

Answer 289

Strengths, School, Home, Activities, Drugs/Substance Use, Emotions/Eating/Depression, Sexuality, Safety

Answer 290

Unconjugated: haemolytic anaemias, Gilberts, Crigler-Najjar. Conjugated: Viral (HAV HBV HCV HDV HEV EBV CMV EBV) Metabolic (Wilsons, alpha1 antitrypsin, CF) Biliary (stones, cholecystitis, choledochal cyst, sclerosing cholangitis) Autoimmune liver disease (type 1 antiSM Ab, type 2 anti-LKM Ab) Hepatotoxins (drugs eg COCP, antiTB, paracetamol, alcohol, organophosphates) Vascular (Budd-Chiari, Venoocclusive disease)

Answer 291

1 Vaccination HAV HBV HPV Mpox MenB 2 PrEP PEPSE 3 Condoms 4 DoxyPEP. PEPSE = post-exposure prophylaxis after sexual encounter

Answer 292

Infantile HIV encephalopathy, speech and language delay, behavioural difficulties, learning difficulties, mental health. Perinatally acquired HIV: neurotropic virus, chronic inflammation, previous CNS infections, complex psychosocial/family circumstances, antiretrovirals, in utero drug exposure, prematurity, malnutrition

Answer 293

Emerging PaHIV data in adult life (even with viral suppression) - increased risk of CVS, metabolic syndrome, DM2, chronic lung disease, malignancy (lymphoma, cervical, HCC, KS)

Answer 294

Non-judgmental MDT adherence support, ART. Stigma (in healthcare, in families, in relationships) -> 25% MH diagnosis, 50% parental loss, 33% learning difficulties -> poor adherence, LTFU -> HIV associated morbidity onward transmission

Answer 295

LL infantum, transmission Sandfly (dusk-dawn biters), Incubation weeks-months. Clinical manifestations: papule>nodule>plaque>ulcer (painless, indurated). Single or multiple +/- regional lymphadenopathy. Typically on exposed skin. Often in normal hosts. Diagnosis: Punch biopsy or skin scapings. Histology, PCR +/- culture. Treatment options: Nothing, intralesional cryotherapy, intralesional stibogluconate (painful), topical paromomycin systemic ambisome or antimonials, especially if multiple, risk of dissemination or risk of mucosal leishmaniasis. Follow up: can reactivate or relapse (usually within 1 year but also with future immunosuppression eg chemotherapy, chronic steroids, when it can disseminate). Having CL doesn't imply VL esp if immunocompetent

Answer 296

Epi: Most UK cases acquired overseas esp Pakistan, India, Bangladesh. Children 30%, XDR Pakistan, Incubation 7-21d. Clinical: fever +/- rigors (often prolonged), GI symptoms (pain, diarrhoea, constipation), myalgia, arthralgia, cough, headache, delirium/drowsiness, rose spots, hepatosplenomegaly (up to 37% in non-endemic, 90% in endemic). Ix: Serial BC, routine susceptibilities and WGS, stool cultures, full infection screen (eg malaria), FBC, EUC< LFT, CRP, Treatment: non-XDR endemic, uncomplicated oral Azith 7d, complicated CRO 7-10d.. XDR endemic, uncomplicated oral Azith 7d, complicated Mero 10d + azith. *Public Health Notification*

Answer 297

Clinical: subacute pulmonary infection, incubation 3-21d, mild symptoms: fever, headache, myalgia, anorexia, cough and chest pain, disseminated in immunocompromised. Treatment: prolonged antifungal therapy - itraconazole, if disseminated/unwell/immunocompromised - amphotericin B

Answer 298

RF: Pf>Pv>others. First pregnancy (high transmission areas), placenta or cord blood film+, Clinical: presents at 2-8w, fever, poor feeding, D&V, irritability, splenomegaly, thrombocytopaenia, anaemia, raised bilirubin. Ix: Cord blood film & RDT, Placenta; histo for parasites, at birth and weekly for 4 weeks: film, RDT, FBC, clinical review. Treatment: admit, artemisinin combination therapy (ACT) if severe IV artesunate

Answer 299

Up to 10% of HIV vertically infected infants who are undiagnosed and untreated will reach adolescence - slow progressors. Appearances can be deceptive - always test for HIV. Close follow up and monitoring for side effects/OI/IRIS essential in early stages. Differences in HIV management between high and low income and HIV endemic and non-endemic centres. Resources for paediatric HIV: CHIVA, Penta, PVC

Answer 300

Burkholderia pseudomallei, Transmission: percutaneous from soil and haematogenous spread, inhalation during severe storms, ingestion of contaminated water in some areas. Distribution: endemic in SE Asia, South Asia, China and Northern Australia. Most cases from Thailand, Malaysia, Singapore and Northern Australia. Sporadic elsewhere. Reports of environmental transmission outside endemic areas from aromatherapy spray and tropical fish. Incubation: usually 1-21d but can establish latency analogous to TB, longest documented time from travel to endemic area and disease is 29y. Clinical manifestations: pneumonia, bacteraemia, skin infections, parotitis, GU infections, less often BJI and neurological. Diagnosis: microscopy and culture of fluid (blood, sputum, BAL, pus, urine etc), cultures on standard media, Ashdown's is selective for it +/- MALDI-ToF/PCR). Treatment IV Ceftazidime (or a carbapenem) for 14d, then high dose cotrimoxazole for 3-6 months. Follow up: monitor for relapses, low threshold for ceftazidime if future severe pneumonia/sepsis. Melioidosis occurs much less commonly in children than adults (5% of all cases <15y), less often associated with underlying immunodeficiencies and comorbidities (diabetes, CKD, EtOH). More likely to be localised/cutaneous presentation (46% of cases), less likely to be bacteraemic. Lower mortality rate (outside the neonatal period). Guidelines for an oral-only approach (3/12 high dose cotrimoxazole with folic acid) without an IV intensification phase for cutaneous disease if systemic spread has been ruled out (US abdomen, CXR and baseline bloos). Non-evidence based. Need to ensure adherence and follow up

Answer 301

B pseudomallei is a hazard group 3 pathogen, ideally should be handled in biosafety level 3 facility in a biosafety cabinet. Some case reports of laboratory acquisition, though appears rare in practice. Risk assessment: prophylaxis for high-risk lab exposure (aerosol, needlestick, splash to mucus membrane) or high risk person (comorbidities) - 3 weeks of SXT or Amox/Clav, take serology on D1 and repeat at 2, 4, 5 weeks. If seroconverts then 3/12 PEP

Answer 302

Transmitted by biting insect, live in nodule, microfilaria live in skin and eyes. Ivermectin kill microfilaria but ton the adult worm - have to treat for 15y to eradicate from human. Diagnosis by skin snip in saline, review 1h later to see microfilaria. Elimination target = prevalence <0.1% in children, with absence of infective larvae in vector population (<1 infected blackfly per 2000 - need to test 6000). In Loa loa endemic areas - use LoaScope mobile-phone based video microscope to count L loa microfilariae in peripheral blood collected in capillary tube

Answer 303

Target <1 case per 10,000 at global level - with new target of zero grade 2 disability among paediatric leprosy patients, reduction of new leprosy cases with G2D to <1 per million population, confirmed absence of children with leprosy for 5 consecutive years, and zero countries with legislation allowing discrimination on basis of leprosy. Positive outcomes: commitment by governments/donors, simplified diagnosis. Negative outcomes: attempts to meet targets led to underreporting, case definition changed, shortage of drugs, funding and trained staff once target achieved, and transmission continues (esp in India)

Answer 304

90% reduction in the number of people requiring interventions against NTDs. Global eradication aim: Guinea worm, Yaws. Elimination: HAT T gambiense from 15 countries, Leprosy from 120 countries, Onchocerciasis from 12 countries. Elimination as a public health problem: Trachoma (already met), Lymphatic filariasis (80% have met), VL (64 countries have met target <1% CFR), Others: STH, Chagas, Rabies (zero human deaths), HAT T rhodesiense, Schisto

Answer 305

Move away from siloed care - put all skin diseases together -

Answer 306

Yaws, Leprosy, Onchocerciasis, Lymphatic filariasis, Buruli ulcer, Cutaneous leishmaniasis, Mycetoma/chromoblastomycosis, Post kala-azar dermal leishmaniasis, Scabies, Tungiasis

Answer 307

Podoconiosis is not infectious - no organism is responsible. Diagnosis uses a panel approach rather than single POCT, it is treatable using simple lymphoedema management package, for which patients can take responsibility. Treatment brings radical improvement in quality of life for stigmatised and marginalised people. Preventable by avoiding contact with irritant soil, primarily by wearing shoes - but needs to be with a package of education and sustainable shoe sources. Elimination is possible through behaviour change and accessible treatment

Answer 308

Subsistence farming communities, prolonged exposure of barefeet to soil. 17 countries, 12 in Africa, others include India, Sth America, Indonesia. Triggered by combination of factors: exposure to irritant soil, genetic susceptibility and foot vulnerability (lack of shoes, hygiene). Tend to be >1500m above sea level (LF <1000m)

Answer 309

Commonly confused with lymphatic filariasis. Bilateral in 87%. Early signs: itching, burning, splaying of forefeet, reversible plantar oedema, hyperkeratosis. Late signs: persistent oedema, interdigital maceration, nodules, waterbag or fibrotic swelling. Differential diagnoses: LF, onchocerciasis, leprosy and protein-energy malnutrition in children. Clinical staging 1 reversible overnight, 2 below knee not completely reversible overnight (below ankle), 3 as for 2 but present above ankle, 4 Above knee, 5 joint fixation, swelling at any place in the foot or leg (different from Dreyer staging for LF)

Answer 310

Acute episodes characterised by malaise, fever, chills, diffuse inflammation and swelling of the limb, lymphangitis, adenitis and skin peeling - requires analgesia, fluids, antibiotics, rest and elevation - during acute episodes do not exercise, put anything warm or hot on skin, open or cut blister, bandage leg, rub anything into the skin or use scarification - these will exacerbate the attack

Answer 311

Hygiene, Skin care, bandaging, elevation and exercise, footwear

Answer 312

Burden not well understood or described. Disease known for over 1000 years, 1994 declared PH problem, 140,000 estimated new cases per annum. No proven risk factors, but likely to be a combination of chronic malnutrition, comorbidities (recent measles, probably malaria), lack of access to quality health care including childhood vaccines, not being breastfed, poor oral hygiene practices, low SES, high number of previous pregnancies in the mother. Noma Children's Hospital run by Nigerian MoH - care for noma sequela - blocks of 30-35pt have surgery and then rehabilitation, occurs 3-4 times per year

Answer 313

Rapidly acting orofacial gangrene, reportedly 90% mortality if untreated - rapid progression within 2-3 weeks. Mostly affects children aged 2-5y, very occasionally adults with advanced HIV or lymphoma. Minimal research available Reversible stages: 0 Simple gingivitis (warning sign, Rx high protein diet, good oral hygiene, chlorhex mouth wash) 1 Acute necrotising gingivitis (admit, amox/clav and metro plus malnutrition management) 2 Oedema (IV Amox/Clav, Metro, Gent, Vitamin A (helps mucosa), improve nutrition), Irreversible stages: 3 Gangrene (Debridement, IV Amox/Clav Metro, Gent) 4 Scarring (if survive gangrene - only 10% survive to this point) 5 Sequela (stigma, poor oral opening, loss of teeth, inability to eat or talk easily, lots shunned within community - surgical intervention is the only way of improving quality of life)

Answer 314

Tooth abscess, cellulitis, animal bites, burn injuries, syphilis, yaws, buruli ulcer, leprosy, oral cancer, chemical burns and burns in general. Distinguishing factors of noma: face, age (2-5), fetid odour, short time frame, well demarcated perimeter, comorbidity. Rapid destruction of tissue is typical of noma

Answer 315

Antibiotics, wound debridement, nutritional support, reconstructive surgery, physiotherapy (backbone of care and not available in most settings), psychosocial support

Answer 316

Emergency Triage Assessment and Treat. SSSS-ABCD Safe, Stimulate, Shout for help, Setting (what is available). Airway Breathing Circulation Disability

Answer 317

Suction, Airway opening manoeuvres, Airway adjuncts

Answer 318

Look, listen, feel, if absent/inadequate give 5 breaths with bag-valve mask

Answer 319

Feel large artery, Dehydration (cap refill, skin turgor) Malnutrition (MUAC, buttock wasting, oedema), Anaemia (compare parent and child palmar pallor). FEAST Trial demonstrated worse outcome in fluid bolus. Dehydration 30ml/kg over 30-60min then 70ml/kg over 2-4h. Malnutrition 10ml/kg/hr 5%D, Anaemia 10ml/kg/h PRBC

Answer 320

BSL, AVPU, Seizure Mx (Benzo in paeds - although in reality, whatever you have...)

Answer 321

Practice that reinforces an imbalanced power structure, institutional rules that further concentrate power among the wealthy and influential. Assumption that resource-limited sector lacks the capacity to solve its own health problems. Manifests as power imbalance, top-down priority setting, verticalisation of intervention (disrupting an existing structure) with disregard for local culture and staff

Answer 322

Task shifting - limited doctors, pharmacists, use community to dispense medications. Integrated approach - HIV and NCD, context-based approaches. Simplification of treatment - difficult to manage at primary health centre - started concept of simplified treatment in terms of monitoring and follow up

Answer 323

Multidisciplinary subspecialty committed to the prevention and management of health problems and risk associated with international travel and travellers. People, diseases, wildlife and other threats cross borders

Answer 324

Diverse group - older, younger, comorbidities, immunosuppressed, PSAR. Changing disease patterns in over 220 countries. Preventive/therapeutic interventions change. Limited evidence base. National and international guidelines differ. Understanding and communicating risk. May find cost of interventions prohibitive. Those that travel go to more remote/exotic locales, do more 'risky things' while abroad, may not seek advice, don't do what they say they will and have their own perception and tolerance of risk. >95% of travel associated illness is not preventable

Answer 325

Who is this person? Risk thresholds are important. Causes of severe morbidity in travellers: associated with pre-existing medical condition, identifiable pre-travel, the added risk of pre-existing conditions is difficult to quantify, particularly affects the older traveller. Risk assessment reflects the health risks and not the interventions available, is it common, treatable/avoidable and/or potentially fatal, individual risk threshold, evidence not perception or intuition

Answer 326

What do they plan to do, where and with whom? Visiting friends and relatives, travellers/expats, business/migration etc. Where in the country? Spectrum of disease vs place of exposure is important and not everywhere in one country will have the same exposure risks

Answer 327

How long are they going for, what is the season

Answer 328

Malaria prevention, vaccines, non-vaccine preventable infections. Other: sexual health/altitude/DVT/trauma/security/insurance, patient education

Answer 329

Patient's agenda, Clinician's agenda, Negotiate agenda and clarify boundaries. Ask before advise - ask permission to discuss, ask what the patient thinks about their health, ask questions to find out what they already know, tell patient information in a way that is easy to understand, gauge the patient's understanding. People like numbers for risk assessment - MedRA can assist in risk ratio.

Answer 330

T1 concern for mother: miscarriage, ectopic, bleeding, retained products, N&V, DVT, infection. T2 concern for mother: congenital abnormalities, anaemia, DVT, gestational diabetes, hypertension, infection T3 concern for mother and baby: premature labour, stillbirth, post partum haemorrhage, DVT, hypertension, pre-eclampsia, infection. Mitigation of risks of above (include early USS - heart beat reduces miscarriage to <5%), and consider malaria, vaccines, travel specific infections, insurance, other

Answer 331

Pregnancy (conception to 6w pp). Flights/journeys >4h, older age, previous clot, family history, additional clotting disorder, obesity, severe oedema, immobility, other medical conditions. Risk reduction: compression stockings, hydration, mobilisation, aisle seat, no EtOH or sleeping medication. Low molecular weight heparin safe in pregnancy

Answer 332

Pertussis, RSV, flu and COVID. No evidence of harm from inactivated vaccines. Live - balance risk vs theoretical fetal harm. Inadvertent vaccine administration is never an indication for termination.

Answer 333

UTI, GI, Resp, Listeria, Malaria, Arboviral, Hep A/E, Toxo, AMR

Answer 334

Risk assessment and risk benefit are unique to each traveller and should be evidence based where possible. Shared decision making is essential, especially where evidence is lacking. Exacerbation/complications of chronic illness and motor vehicle accidents are the leading causes of death and severe disability. Promoting/changing behaviour requires effective communication and skill, but has not been proven effective.

Answer 335

Safe, less robust immune response, multiple doses often needed. Waning immunity. Include: pneumococcus, IPV, hepatitis, DTP, typhoid

Answer 336

Robust immune response, often lifelong immunity but potential vaccine-derived infections. Include: MMR, YF, OPV, Zoster

Answer 337

1 Antigen presentation (dendritic cell) or LN 2 Activation of cell cycle and clonal expansion of T cells 3 Activation and clonal expansion of B cells. Vaccines provide long term protection through Ab persistence above threshold +/- memory cells --> rapid clonal expansion on exposure to pathogen (second immune response is robust and swift

Answer 338

Primary: SCID, CVID, DiGeorge, IgA deficiency. Secondary/acquired: physiological state, illness or treatment for a condition that reduces immune function (HIV, extreme of age, pregnancy, malignancy, post BMT, medication

Answer 339

Reduced number of antigen presenting cells. Reduced proinflammatory toll-like receptor response to antigen presenting cells, increased inflammation, specific adjuvants, revaccination before old age is ideal. Might need vaccines with specific adjuvants to stimulate the immune system

Answer 340

Individualised risk profile (person, place, time), country regulations/requirements, future travel, individual preference, vaccine availability, cost, time, safety, epidemiology, population level risk/public health benefit, cost effectiveness, safety, acceptability

Answer 341

Measles, Hepatitis A, Typhoid, Dengue, Rabies

Answer 342

Wash wound for 15 min with soap and water seek medical attention ASAP, DTP booster if required, Simian Herpes B virus: Macaque monkeys in SEA - aciclovir within 5d for 14d. Rabies PEP +/- HRIG

Answer 343

Vaccinate: Hib, Nmen ACWY & B, Pneumococcus, Influenza. Prophylax abx: penV +/- standby abx. Other infection risks: Malaria, Babesiosis

Answer 344

Men ACWY at least 10d before travel, polio if travelling from country with wild-type polio, YF if travelling from 'at risk country', COVID-19, influenza, hepatitis B, Rabies, and consider risks for MERS-CoV, diarrhoea

Answer 345

Update routine vaccinations (MMR), check certification requirements (YF, polio, Men ACWY, COVID), check additional person specific risks (immunocompromised, pregnant), consider levels of sanitation (Hep A, typhoid, cholera), estimate additional risks (animal bites, HBV, JE, TBE, flu etc)

Answer 346

Abnormal opening between the vagina and other nearby organs in the pelvis, including the bladder or rectum. A fistula can cause many complications, such as urinary and faecal leakage, abnormal vaginal discharge, tissue damage, kidney infections and other irritative type symptoms. It often, but not always, leads to infertility. There are several types of fistulae defined by the location vesicovaginal (bladder), rectovaginal (rectum), colovaginal (large intestine), enterovaginal (small intestine), uretovaginal (ureter), urethrovaginal (urethra)

Answer 347

Prolonged or obstructed labour, distended bladder, use of oxytocin, failed instrumental delivery, rupture or pre-rupture of uterus. Most prevalent in marginalised members of population: teenagers, child brides, poor SES, low education, rural or remote regions.

Answer 348

Rising cause, often by unsafe surgery eg hysterectomy, caesarean hysterectomy and caesarean delivery. Root causes include gaps in healthcare worker density, skill sets and infrastructure. Gynaecological and obstetric operations should be restricted to authorised, registered and trained surgeons.

Answer 349

1 Advocate for and ensure safer surgery practices at health facilities/institutions. 2 Advocate for/ensure safer surgery at the national level. 3 Advocate for/ensure safer surgery at the international level. 4 Reduce non-indicated Caesarean section rates

Answer 350

Estimated 2 million women affected, incidence 50-100,000 new cases per year. Decreased in HIC, remains a major public health challenge in LMIC

Answer 351

Loss of job and income, stigma, loss of community and family (often childless), constant leaking of urine leads to smell, fear, economic consequences of other obstetric injuries such as wounds or foot drop, homelessness, begging, loss of financial security when husbands divorce/leave them, infertility and inability to engage in sex, costs of buying soap, pads, hygiene, unable to afford nutritious food or education for children. Concerns about cost of treatment are a significant barrier to care - despite care being 'free' in many countries, the costs of food, clothing, travel and medications can be prohibitive, costs associated with traditional healers, difficulty in accessing money if household finances controlled by men, loss of income whilst receiving care

Answer 352

Primary (health promotion, planned pregnancies, birth spacing, contraception, community awareness). Secondary (antenatal care, skilled health personnel at birth, partograph use, identification of signs and symptoms of obstructed labour, immediate referral, bladder care and/or catheterisation during labour if needed). Tertiary (access to emergency obstetric and neonatal care, use of indwelling catheter)

Answer 353

Ummer myometrium becomes tense, lower becomes oedematous and peri-rupture

Answer 354

Diagnosis of GU fistula, after 2 weeks continuous catheterisation, pack vagina with gauze, inject methylene blue into catheter, observe gauze for blue discolouration. If positive, continue catheter and recheck again in 4 weeks, if remains positive again (6w) refer for surgery

Answer 355

Surgical access is key to quality repair and prevention of both obstetric and iatrogenic fistula. Repair is a complicated procedure and should be performed by subspecialist. Coordination should liaise with national and international facility to provide care

Answer 356

Genitourinary fistula is important, preventable and treatable. It has devastating consequences for individuals, families, communities and countries. It is possible to eradicate them entirely and good work is being done to do so. The pathophysiology of obstetric fistulas is simple but the prevention and treatment is complex. The root cause of the significant rise in iatrogenic fistula is access to specialised surgical input. There is a role for the non-specialist in diagnosis, data-collection and referral pathways, prevention of new cases, advocacy work in promoting training for healthcare professionals (esp midwives), advocacy for access to comprehensive healthcare, advocacy and healthcare design for access to contraception and abortion services, and the promotion of safe surgery across the board.

Answer 357

810 women die daily from preventable causes related to pregnancy and childbirth. 94% of maternal deaths occur in LMIC, maternal mortality is higher in women living in rural areas and among poorer communities. Young adolescents (10-14y) face a higher risk of complications and death as a result of pregnancy than other women. Skilled care saves lives. No woman should die in pregnancy or child health.

Answer 358

Maternal collapse, septic abortion/termination of pregnancy (TOP), management of miscarriage, ectopic pregnancy

Answer 359

Maternal collapse, VTE (DVT/PE), HTN (PET/ET), Sepsis, Antepartum haemorrhage (APH)

Answer 360

Umbilical cord prolapse, shoulder dystocia, breech delivery, hypertension (PET/ET), sepsis

Answer 361

PPH -> massive obstetric haemorrhage (MOH), VTE (DVT/PE), HTN (PET/ET), Sepsis

Answer 362

15% of pregnant women will have a potentially life threatening complication, the majority of which are unpredictable. Know what equipment is available and where it is. Organise emergency boxes/bags with clearly labelled drugs, equipment and protocols, and run simulation. Always come back to ABC

Answer 363

Affects all societies, all ages, all genders, all socioeconomic groups. There is an overlap with other types of abuse. It has a significant impact and consequences on the individual, secondary survivors, society, impact on GDP and local economy.

Answer 364

1 Assessment of injuries 2 Risk of pregnancy 3 Emergency contraception 4 Sexually transmitted infections 5 Mental health assessment - remember will not have a positive urinary pregnancy test until 3 weeks post event

Answer 365

Threatened: light bleeding, abdominal pain, cervix closed. Incomplete: more or less bleeding, abdominal pain, uterine contractions, open cervix. Trauma to vagina or cervix or presence of a foreign body are strongly suggestive of unsafe abortion. US is Ix of choice. If threatened - advise to reduce activity, look for a possible cause and treat pain. If missed - no urgency for uterine evacuation (use misoprostol or manual vacuum). Ongoing or incomplete: general measures, ABC, treat pain, remove POC from vagina and cervix, look for cause (malaria, STI). Septic abortion: (fever, abdo pain, tender uterus, foul-smelling discharge) do as above, plus remove foreign bodies from vagina and cervix, uterine evacuation ASAP and administer Abx

Answer 366

NSAID, Tranexamic acid on bleeding days, COCP, oral progesterone, refer for gynae input. Consider CaCx

Answer 367

Symptoms (lower abdo/pelvic pain, mucopurulent discharge, fever, loss of appetite/vomiting, intermenstrual bleeding, heavy menstrual bleeding, deep dyspareunia, later subfertility/ectopic), Examination (cervical motion tenderness, mucopurulent discharge, friable cervix) Admission if (febrile, tachycardic, rebound tenderness, pelvic mass) Antibiotics (CRO plus Doxy plus Metro for 14d), treat partner,

Answer 368

Maternal mortality does not just happen at delivery. Medical leadership in organisation, planning, preparedness and training could be initiated by a non-specialist. Always come back to ABC, always do a urine pregnancy test. Young women don't decompensate until the very end - don't rely on hypotension and tachycardia. Safeguarding and contraception are the forgotten heroes of gynaecology. Women need good healthcare to thrive. It is a human right, not just when they are pregnant. Without addressing this significant burden, global goals and targets such as the sustainable development goals cannot be met.

Answer 369

Individuals, communities, nations and organisations all have a complex past, and their histories (what has happened, and also what stories are told about the past) will affect how they behave today and tomorrow. Today's inequalities in health have deep historical roots. Power imbalances in terms of whose knowledge matters, and whose health matters, were established through colonialism and persist today. Tropical medicine (and hygiene) was entangled with empires, economics, exploitation, politics, and racism: it went on to become entangled with global health - which retains many of these entanglements. Healthcare past and present is a lot to do with human decisions concerning resources, priorities, expertise, and evidence, in society: it's affected by power relationships and its always political. BUT that doesn't mean we give up and go home. What can we do with this? Listen for the histories (of nations, communities, individuals, and organisations) that you encounter: they will help you understand what's happening now. Reflect on your own history; how it shapes your experiences and views of the world; and how other histories will differ. Ask questions about the past, in relation to people and places as well as problems. Be alert to the risks of falling too easily into the well-trodden pathways set by the past. Think about how you, in your future work, might want to confront negative legacies from the past (and build on past strengths)

Answer 370

One third of income inequality today can be explained by the impact of European colonialism. Colonialism led to an increase in the national income of colonising nations of between 14-79%. $45 trillion was taken from India by Britain between 1765 and 1938.

Answer 371

A large, composite, multi-ethnic, or multinational political unit, usually created by conquest, and divided between a dominant centre and subordinate, sometimes far distant, peripheries.

Answer 372

The actions and attitudes which create or uphold such big political units. This is about exercising power and influence: it can be economic and/or cultural; and can be enacted at a distance

Answer 373

Direct or indirect political rule by a foreign state: particularly European practices from the 1600s onwards (Spain, Portugal, France, Britain, Belgium, Netherlands) involving the movement of people and/or control of economic resources

Answer 374

Tropical' regions near the equator. But the interest of tropical medicine were not uniquely problems of the 'tropical' regions. Late 19th century: dengue, malaria, yellow fever, cholera, leprosy, plague, smallpox. 20th century: TB, syphilis, mal/nutrition, HIV and AIDS. Early features of tropical medicine: attention to climate and environment as they might affect health; attention to racial difference as explanation for health outcomes; confidence that knowledge and expertise lie in Europe (and later, the USA/'global north')

Answer 375

Health 'is a fundamental human right and the existing gross inequality…between developed and developing countries is politically, socially, and economically unacceptable…primary health care is essential health care based on practical scientifically sound and socially acceptable methods and technology made universally accessible...bringing health care as close as possible to where people live and work' BUT: Global financial problems of the 1970s, the involvement of the World Bank, and political shifts (post-Cold War, neoliberalism) led to a renewed focus on selective (vertical) interventions.

Answer 376

ARF (acute rheumatic fever): acute multisystem inflammatory process occurring 2-3 after GAS pharyngitis. RHD (Rheumatic heart disease): chronic process due to scarring of valves during ARF associated with complications such as heart failure and death. GAS: S pyogenes, Gram positive beta-haemolytic cocci in chains

Answer 377

Not straightforward to diagnose, significant underestimates. Global prevalence estimate ~33m

Answer 378

ARF: 5-15yo in high risk population, dominant features are joint pain, carditis (and chorea), classically 10-14d following GAS pharyngitis. Diagnosis based on Jones Criteria

Answer 379

GAS plus 2 Major or 1 Major and 2 Minor (Major: Carditis, Arthritis, Chorea, Subcut nodules, EM) (Minor: Polyarthralgia, Fever>38.5C, ESR>60 or CRP>30, Prolonged PR) - in high risk areas polyarthralgia upgraded to Major, and monoarthralgia to minor, and fever limit dropped to 38

Answer 380

Carditis (50-65%, MV first, echocardiographic criteria, rarely peri/myocarditis). Arthritis (migratory, large joint arthritis, very responsive to NSAIDs, self-limiting and not deforming). Chorea (movement disorder, relief with sleep, facial grimacing/tongue, spooning/milkmaid's grip) Subcutaneous nodules. Erythema marginatum

Answer 381

Fever, acute phase reactants, heart block

Answer 382

Diagnostics -> Echo +/- antecedent GAS. Patient/family education, analgesia/NSAIDs, diuresis, ACEi +/- steroids. Longer-term prevent recurrence

Answer 383

Prophylaxis: IM penicillin. Anticoagulation: Warfarin (not DOAC)

Answer 384

Case detection, register, prophylaxis, family planning, education & advocacy. Ideally: primary prevention, echo screening, diagnostics, chronic disease, access to surgery

Answer 385

Infection triggered disease of depravity and poverty. Leading cause of cardiac death & disability in young. Challenging diagnosis in challenging settings. Emerging evidence for prevention and therapeutics. Vaccine development is the key longterm goal

Answer 386

Why did this person from this place, develop these symptoms at this time? It is not just as simple as the region, but also the time of year, and the area within the region, and need to have an understanding of the diversity within one country on how to advise.

Answer 387

Lassa (West Africa due to distribution of Multimammate), Ebola (Western/Central Africa linked with distribution of territodidiae fruit bat) Endemic mycoses, Blastomycosis (Northern America), Paracocci (South America), Coccidiodomycosis (Lower North/Central/South America), Talaromycosis (SE Asia), Yellow Fever (Sth America and Africa - Aedes mosquito is found in other parts of the world, esp SE Asia, unclear reasons Yellow fever is not in this region. P knowlesi (Malaysia)