MISC - Prelims Quiz Flashcards by Juan Carlos Cornelio

The functional group present in the antifungal drug Clotrimazole

a. Triazole
b. Imidazole
c. Tetrazole
d. Thiazole

b. Imidazole

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Another name for methylbenzene

a. Anisole
b. Aniline
c. Toluene
d. Styrene

c. Toluene

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Name of a cresol in a 1,4 position

a. n-cresol
b. p-cresol
c. m- cresol
d. o-cresol

b. p-cresol

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Which of the following is a halide?

a. CH3OCH3
b. CH3OH
c. CH3SH
d. CH3F

d. CH3F

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General formula for esters

a. R-OH
b. R-O-R’
c. R-COOR’
d. R-COOH

c. R-COOR’

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Which of the following is a purine?

a. Thymine
b. Uracil
c. Cytosine
d. Guanine

d. Guanine

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Common name for methanal

a. Formaldehyde
b. Prionaldehyde
c. Butyl aldehyde
d. Acetaldehyde

a. Formaldehyde

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Azido group

a. N-=N+=N-
b. -N=O
c. -NH-NH-
d. -N=N-

a. N-=N+=N-

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Which of the following is a monocarboxylic acid?

a. Malonic acid
b. Acetic acid
c. Oxalic acid
d. Succinic acid

b. Acetic acid

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An ortho-disubstituted benzene has its two substituents in a __________ relationship

a. 1,5
b. 1,3
c. 1,4
d. 1,2

d. 1,2

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Which heterocyclic compound contains a 6-membered ring?

a. Azepine
b. Oxirane
c. Thiazole
d. Pyridine

d. Pyridine

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Common name for para-dihydroxybenzene

a. Hydroquinone
b. Resorcinol
c. Catechol
d. Cresol

a. Hydroquinone

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NH3

a. Primary amine
b. Secondary amine
c. Tertiary amine
d. Ammonia

d. Ammonia

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IUPAC name for acetone

a. Butanone
b. Pentanone
c. Propanone
d. Hexanone

c. Propanone

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Phenformin contains what functional group?

a. Guanidino
b. Carbamate
c. Sulfonamide
d. Urea

a. Guanidino

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Cofactor for sulfation

a. UDPGA
b. Acetyl-CoA
c. PAPS
d. SAM

c. PAPS

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Conjugation reaction that produces less polar metabolism

a. Acetylation
b. Sulfation
c. Glycine conjugation
d. Glucuronidation

a. Acetylation

An example of a reduction reaction

a. R-NH-NH-R -> R-N=N-R
b. R-NHOH -> R-NH2
c. R-NHOH -> R-NO
d. R-NO -> R-NO2

b. R-NHOH -> R-NH2

An example of oxidation reaction

a. CH3CH3 -> CH3CH2OH
b. CH3CHO -> CH3CH2OH
c. CH3CH2OH -> CH3CH3
d. CH3COOH -> CH3CHO

a. CH3CH3 -> CH3CH2OH

Reduction of an aldehyde produces:

a. Tertiary alcohol
b. Secondary alcohol
c. Carboxylic acid
d. Primary alcohol

d. Primary alcohol

Major pathway in adults for the metabolism of acetaminophen

a. Methylation
b. Sulfation
c. Acetylation
d. Glucuronidation

d. Glucuronidation

Reduction involves

a. Removal of hydrogen atoms
b. Gain of electrons
c. Addition of oxygen atom
d. All of the above

b. Gain of electrons

Rapid acetylators include:

a. Egyptians
b. Filipinos
c. Caucasians
d. African-Americans

b. Filipinos

Major biotransformation pathway for drugs containing an ester and amide functional group

a. Hydrolysis
b. Reduction
c. Oxidation
d. Methylation

a. Hydrolysis

Major conjugation pathway in cats a. Acetylation b. Glucuronidation c. Methylation d. Sulfation

d. Sulfation

Factors that can affect drug metabolism a. Genetic factors b. Age differences c. Species differences d. All of the above

d. All of the above

__________ drugs are more readily excreted in urine a. Lipid soluble b. Nonpolar c. Unionized d. Water soluble

d. Water soluble

Cofactor for glucuronidation a. Gly b. GSH c. UDPGA

c. UDPGA

Oxidation of a secondary alcohol produces a/an: a. Ketone b. Carboxylic acid c. Aldehyde d. Alkane

a. Ketone

Results from the inability of infants to conjugate bilirubin with glucuronic acid a. Kernicterus b. Grey baby syndrome c. Neonatal hyperbilirubinemia d. Two of the above

d. Two of the above

The R-isomer of ibuprofen is responsible for its anti-inflammatory activity a. True b. False

b. False (S-ibuprofen is responsible for anti-inflammatory activity)

Levorphanol has antitussive activity while dextrorphan has analgesic activity a. True b. False

b. False (Levorphanol=analgesic; Dextrorphan=antitussive)

The physicochemical properties of a drug molecule are dependent not only on what functional groups are present in the molecule but also on the spatial arrangement of those functional groups a. True b. False

a. True

Not all possible enantiomers of a drug are pharmacologically active a. True b. False

a. True

The term product stereoselectivity is used to denote a preference for one stereoisomer as a substrate for a metabolizing enzyme or metabolic process a. True b. False

b. False (Substrate stereoselectivity)

When two substituents of higher priority are on the same sign of the double bond, this isomer is given the designation of trans or E a. True b. False

b. False (cis/Z)

Most sugars found in nature are dextrorotatory while most amino acids found in nature are levorotatory a. True b. False

a. True

Dextroamphetamine, Dextromethorphan, and Dexlansporazole are examples of drugs that rotate the plane of polarized light to the left a. True b. False

b. False (To the right)

A racemic mixture is optically inactive a. True b. False

a. True

Esomeprazole is the S-enantiomer of Omeprazole and Armodafinil is the R-enantiomer of Modafinil a. True b. False

a. True