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Flashcards in Miscellaneous Antibacterial Deck (20)
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1
Q

glycopeptides (vancomycin) inhibit the synthesis of ____ ____ by interfering with cell wall _____

A

cell wall

precursors

2
Q

vancomycin is generally considered ________

A

bacteriocidal

3
Q

all gram negatives and TB (mycobacteria) are ________ to vancomycin

A

resistant

4
Q

vancomycin is great for ____________ and serious conditions like ______

A

MSSA, MRSA

endocarditis

5
Q

Fluroquinoloes (cipro) are _______ and work by inhibiting __________ and ______

A

bactericidal

DNA gyrase and DNA synthesis

6
Q

Fluoroquinolones are excellent for __________ and atypicals

A

gram negatives!!

7
Q

_______ work well on shigella, enterbacter, campylobacter, neisseria. Also work well for _______

A

fluoroquinolones (cipro)

UTIs

8
Q

biggest problem with fluoroquinolones is ___________

A

tendon rupture

9
Q

sulfonamides (folate antagonists) prevent __________

A

PABA (in DNA synthesis)

10
Q

sulfa drugs inhibit both ________ and _______

A

gram negative and gram positive

11
Q

sulfa drugs are often used for _______

A

UTIS

12
Q

toxic epidermal necrolysis is a problem with ______

A

sulfa drugs

13
Q

Trimethoprim concentrate in prostatic and vaginal fluid, so is also used for _______

A

UTIs and prostatitis

14
Q

trimethoprim is more ______ than SMX, so they are often added

A

lipid soluble

15
Q

Metronidazole is a __________ that is used to “clean up” organisms that the other drug classes cant

A

nitroimidazole

16
Q

metronidazole is great at taking care of ______, _____, and ______

A

anaerobes and parasistes

C difficile

17
Q

metronidazole would NOT be used for ______, but good for gram neg and pos ______

A

staph, strep, e coli

anaerobes (bacteriodes, clostridium)

18
Q

metronidazole is a ______, so it requires reductive activation

A

prodrug

19
Q

black box warning for metronidazole may be ________. May also cause _______ _____

A

carcinogenic

peripheral neruopathy

20
Q

notorious drug interaction with metronidazole is ________

A

ALCOHOL!