Mitochondria Flashcards
(6 cards)
1
Q
Outline the mechanisms of mitophagy.
A
3 mechanisms
How each is chosen unclear
All require mitochondria to tag LC3
Parkin (E3 ubiquitin ligase 8) in one mechanism linked to parkinsons?
2
Q
which complexes are the most likely source of ROS’?
A
I and III
3
Q
What do hydroxyl radicals do?
A
Initiate formation of lipid L. and lipid peroxyl LOO. radicals
4
Q
What is change in GO’ defined as?
A
-nF🔺EO’
n= numbers of electrons transferred
F = faraday constant (96.485 kJ/mol)
Rest - change in redox potential.
5
Q
What happens to redox potential along the ETC?
A
It increases.
Proton pumping coupled to energetically favourable reactions.
6
Q
In what type of cell is mitochondrial transport particularly important?
A
Neurons - must be transported to regions of high synaptic activity.
