MMT: lipoprotein metabolism Flashcards
(51 cards)
What is the exogenous lipoprotein?
Chylomicrons
Once chylomicrons donate their TGs, where do they go?
Back to the liver
What is the endogenous lipoprotein?
VLDL
What happens to VLDL remnants?
They return to the liver as LDL or deposit in extrahepatic tissues as LDL
Which lipoprotein is involved in reverse cholesterol transport?
HDL
Arrange lipoproteins in terms of size (large to small).
- Chylomicrons
- VLDL
- IDL
- LDL
- HDL
The density of lipoproteins is largely due to…
Protein; high density have the most protein and least TGs
What does ApoA-I do?
Activates LCAT that helps but cholesterol into HDL
Where is ApoA-I found?
HDL
Where is ApoA-II found?
HDL
Where is ApoA IV found?
Chylomicrons and HDL
Where is ApoB-48 found?
Chylomicrons
Where is ApoB-100 found?
VLDL and LDL
Where is ApoC-I found?
VLDL and HDL
Where is ApoC-II found?
Chylomicrons, VLDL, HDL
Where is ApoC-III found?
Chylomicrons, VLDL, HDL
What does ApoC-III do?
Inhibits LPL
Where is ApoD found?
HDL
Where is ApoE found?
Chylomicrons, VLDL, HDL
What does ApoE do?
Trigger clearance of VLDL and chylomicron remnants
Which apolipoprotein is associated with Abetalipoproteinemia?
ApoB
Where does chylomicron acquire ApoE and ApoC-II?
HDL
Where is VLDL synthesized?
Liver
What does VLDL do?
Transport TGs and cholesterol from the liver to other tissues
