Mock Tests Review

Question 1

Mutation seen in follicular thyroid cancer ?

Answer 1

RAS mutation

Question 2

Mutation in papillary thyroid cancer

Answer 2

BRAF
RET
MET

Question 3

HOW WILL YOU differentiate b/w AML M2 & M3 ?

Answer 3

AML M2- very few auer rods will be seen

AML M3- large number of Auer rods are seen

Question 4

Common mutation seen in

1. AML M2-
2. AML M3
3. AML M4
4. AML M7

Answer 4

1. T(8;21)
2. T(15;17)- PML-RARA
3. INVERSION 16
4. Inversion 3

Question 5

What is chemodectoma ?

Answer 5

A rare neural tumor of carotid body seen later in 5th decade of life

Question 6

Cause of malabsorption in Whipple’s disease ?

Answer 6

Lymphatic obstruction by bacteria containing macrophages

Question 7

M/c site in stomach for gastric adenocarcinoma in INdia and in world ?

Answer 7

India- antrum

World- cardia

Question 8

Pattern of fibrosis in each - NASH & Alcoholic liver disease

Answer 8

NASH- periportal

ALD- peri sinusoidal and perivenular

Question 9

What happens if Rb gene is hypophosphorylated ?

Answer 9

Cell cycle stops at G1

Question 10

All trans retinoids acid is used in t/t for which genetic aberration ?

Answer 10

PML-RARA: t(15;17)

In t/t of APML

Question 11

Various Gleason pattern in Gleason scoring for prostate cancer

Answer 11

Pattern 3- well defined glandular pattern
Pattern 4- cribriform, distorted glandular
Pattern 5- malignant cells are visible all over

There is no pattern 1 & 2

Question 12

Current range of Gleason score

Answer 12

6-10

Question 13

Serotoli cell secretes

Answer 13

FSH

Inhibin- under negative feedback during normal spermatogenesis

Question 14

Various deficit findings in Di-George syndrome

Answer 14

C- cardiac defects
A- abnormal facies
T- thymine aphasia
C- cleft lip
H- hypocalcemia
22- Chrm 22 abnormality

Question 15

Onion skin thickening of vascular wall is seen in

Answer 15

Severe hypertension

Question 16

Increased incidence of cancer in old age is due to

Answer 16

Telomerase reactivation

Question 17

What can be done to prevent febrile non-hemolytic transfusion reaction ?

Answer 17

Leucoreduction of RBCs

Question 18

Wilms tumor is a/w which all syndromes ?

Answer 18

WAGR
Denys-Drash
Beckwith Weidman

Question 19

Presentation of WAGR syndrome

Answer 19

Wilms tumor
Aniridia
Genitourinary abnormality
Mental retardation

Question 20

Wilms tumor gene is located on chromosome

Answer 20

11