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PHASE 2A DRUG LIST > MODE OF ACTION > Flashcards

Flashcards in MODE OF ACTION Deck (32):
1

ALENDRONATE
MoA

Inhibits osteoclast mediated bone resorption by inhibiting the enzyme FPP synthase

2

ATENOLOL
MoA

Binds to beta-adrenergic receptors in the heart and vascular smooth muscle, inhibiting sympathetic stimulation

3

ATRACURIUM
MoA

Binds competitively with cholinergic receptor sites to antagonise acetylcholine action

4

BENDRO-FLUMETHIAZIDE
MoA

Inhibits Cl reabsorption at early distal tubule, results in increase of Na, Cl and water excretion

5

CEFUROXIME
MoA

Inhibition of bacterial cell wall synthesis -> death due to lysis

6

CELECOXIB
MoA

Inhibits Cox-2 cyclooxygenase -> inhibits prostaglandin synthesis

7

CHLORAMPENICOL
MoA

Bacteriostatic – inhibits protein synthesis by interfering with substrate binding

8

CICLOSPORIN
MoA

lymphocyte function
Binds to cytosolic protein, inhibiting calcineurin -> less inflammatory cytokine production

9

CIPROFLOXACIN
MoA

Inhibition of bacterial DNA gyrase enzyme -> prevents DNA replication so stops replication

10

CO-AMOXICLAV
MoA

Beta-lactamase inhibitor + inhibits penicillin binding proteins -> inhibits bacterial cell wall synthesis

11

DIAMORPHINE
MoA

Mu-opioid agonist
Acts on receptors in the CNS which produces an analgesic effect

12

DALTEPARIN
MoA

Inhibits the formation of factor Xa and thrombin

13

DOBUTAMINE
MoA

Directly stimulates Beta-1 receptors in the heart, increases myocardial contractility and stroke volume

14

DOXAZOSIN
MoA

Inhibits postsynaptic alpha 1 adrenoceptors on vascular smooth muscle – peripheral vasodilation

15

EPHEDRINE
MoA

Stimulation of adrenergic receptors
Increases noradrenaline action and release

16

ERYTHROMICIN
MoA

Inhibits bacterial protein synthesis
Bacteriostatic/cidal dependent on dose

17

ETHINYLESTRADIOL
MoA

Interaction with oestrogen receptors in target cells

18

FUROSEMIDE
MoA

Inhibits water reabsorption in the nephron (blocks Na-K-Cl cotransporter)

19

IPRATROPIUM
MoA

Blocks muscarinic ACh receptors, promoting cGMP degradation – reduces bronchoconstriction

20

LOPERAMIDE
MoA

Acts on mu-opioid receptors in PNS -> slows intestinal motility
Doesn’t cross the BBB so can’t affect CNS

21

METFORMIN
MoA

Decreases hepatic glucose production and intestinal glucose absorption
Improves insulin sensitivity

22

METHOTREXATE
MoA

Cancer – inhibition of DHFR, inhibiting folate synthesis.
Arthritis – inhibition of purine metabolism = accumulation of adenosine = suppression of T cells

23

OXYBUTININ
MoA

Antagonist of M1, 2 & 3 muscarinic ACh receptors
Decreases muscle spasms of the bladder

24

PARACETAMOL
MoA

COX enzyme inhibition in CNS indirectly

25

RAMIPRIL
MoA

Inhibit ACE activity
Less Angiotensin II produced
Less Bradykinin breakdown
Relaxation of arterial smooth muscle

26

RIFAMPICIN
MoA

Inhibits bacterial RNA polymerase enzyme – no RNA synthesis

27

RIVAROXIBAN
MoA

Competitive irreversible inhibition of factor Xa.
Prevents thrombin formation

28

SALMETEROL
MoA

Beta 2 stimulation causes relaxation of bronchial smooth muscle

29

SILDENAFIL
MoA

Increases cGMP to cause smooth muscle relaxation - vasodilation

30

SUXAMETHONIUM
MoA

Mimics ACh at NM junction, with slow hydrolysis – prolongs depolarisation = NM blockade

31

TAMSULOSIN
MoA

Selective A1 antagonist
Causes relaxation in smooth muscle = less resistance to urinary flow=less pain in BPH

32

TRAMADOL
MoA

Agonist of mu-opioid receptors
Serotonin & norepinephrine reuptake inhibitor
Enhances serotonin release